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Report error Found 2119 of affinity data for UniProtKB/TrEMBL: O43353
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50537138BDBM50537138(CHEMBL4531690)
Affinity DataIC50: 0.0110nMAssay Description:Displacement of fluorescent tracer from N-terminus of human RIPK2 expressed in HEK293T cells after 2 hrs by NanoBRET target engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50574936BDBM50574936(CHEMBL4857880)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of full length His-tagged RIPK2 (unknown origin) expressed in baculovirus expression system using fluorescent labelled ATP competitive lig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50574935BDBM50574935(CHEMBL4866182)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of full length His-tagged RIPK2 (unknown origin) expressed in baculovirus expression system using fluorescent labelled ATP competitive lig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597348BDBM50597348(CHEMBL5177284)
Affinity DataKd:  0.280nMAssay Description:Binding affinity to human RIPK2 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597348BDBM50597348(CHEMBL5177284)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of full length FLAG His-tagged RIPK2 (unknown origin) expressed in Baculovirus by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597348BDBM50597348(CHEMBL5177284)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of RIPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 303361BDBM303361(US10138222, Example 76)
Affinity DataIC50: 0.610nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405272BDBM50405272(BDBM50516678 | CHEMBL4596287)
Affinity DataKd:  0.780nMAssay Description:Binding affinity to RIPK2 (unknown origin) assessed as dissociation constant by kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597341BDBM50597341(CHEMBL5187454)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human RIPK2 incubated for 120 mins in presence of [gamma33P]ATP by scintillation counting based radiometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 303364BDBM303364(BDBM303369 | US10138222, Example 79)
Affinity DataIC50: 0.810nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 303360BDBM303360(US10138222, Example 75)
Affinity DataIC50: 0.900nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 303438BDBM303438(US10138222, Example 166)
Affinity DataIC50: 0.940nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 303440BDBM303440(US10138222, Example 168)
Affinity DataIC50: 0.950nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 303823BDBM303823(US10138241, Example 7 | US11130754, Example 7 | US...)
Affinity DataIC50: 0.990nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 303823BDBM303823(US10138241, Example 7 | US11130754, Example 7 | US...)
Affinity DataIC50: 0.990nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 303823BDBM303823(US10138241, Example 7 | US11130754, Example 7 | US...)
Affinity DataIC50: 0.990nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786562BDBM786562(N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786568BDBM786568(N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786557BDBM786557(N-(5-(6- (cyclopropylsulfonyl)-7- methoxyimidazo[1...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786558BDBM786558(N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786293BDBM786293(N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 303359BDBM303359(US10138222, Example 74)
Affinity DataIC50: 1nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786423BDBM786423(N-(5-(5-(tert- butylsulfonyl)-6- methoxypyrazolo[1...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 303380BDBM303380(US10138222, Example 105)
Affinity DataIC50: 1nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786473BDBM786473(rac-4-((4-(6-(tert- butylsulfonyl)-7- methoxyimida...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786474BDBM786474((1s,3s)-3-((4-(6- (tert-butylsulfonyl)- 7- methoxy...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786475BDBM786475(rac-(1R,3S)-3-((4-(6- (tert-butylsulfonyl)- 7- met...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786476BDBM786476((1r,3r)-3-((4-(6- (tert-butylsulfonyl)- 7- methoxy...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786477BDBM786477(N1-(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786478BDBM786478((R)-3-((4-(6-(tert- butylsulfonyl)-7- methoxyimida...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786465BDBM786465(5-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786466BDBM786466(3-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786467BDBM786467(5-(((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786468BDBM786468(5-(((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786469BDBM786469(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- ...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786470BDBM786470(1-(2-((4-(6-(tert- butylsulfonyl)-7- methoxyimidaz...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786471BDBM786471(4-(((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786472BDBM786472(4-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786600BDBM786600(US20250346593, Example 317)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786458BDBM786458(N-benzyl-4-(6-(tert- butylsulfonyl)-7- methoxyimid...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786459BDBM786459(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- ...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786460BDBM786460(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- ...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786461BDBM786461(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- ...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786462BDBM786462(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- ...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786463BDBM786463(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- ...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786464BDBM786464(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- ...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786577BDBM786577(N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,...)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786452BDBM786452(US20250346593, Example 169)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322535BDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human His-tagged RIPK2 (8 to 317 residues) incubated for 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 786453BDBM786453(US20250346593, Example 170)
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

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