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TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50511993(CHEMBL4472879)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity at TLR2 in human cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358558(CHEMBL1923557)
Affinity DataEC50:  0.260nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50552141(CHEMBL4756806)
Affinity DataEC50:  0.280nMAssay Description:Agonist activity at TLR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50526708(CHEMBL4552043)
Affinity DataEC50:  0.281nMAssay Description:Agonist activity at human TLR2 expressed in HEK-Blue cells co-expressing NF-kappaB-SEAP reporter gene measured after 16 hrs by SEAP reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50552143(CHEMBL4759425)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at TLR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetTLR2/TLR6(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50399457(CHEMBL2179400)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human TLR2/TLR6 expressed in HEK-Blue hTLR2-TLR6 cells by SEAP reporter gene based Quanti-blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50526714(CHEMBL4442356)
Affinity DataEC50:  0.304nMAssay Description:Agonist activity at human TLR2 expressed in HEK-Blue cells co-expressing NF-kappaB-SEAP reporter gene measured after 16 hrs by SEAP reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50552142(CHEMBL4791879)
Affinity DataEC50:  0.380nMAssay Description:Agonist activity at TLR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50526709(CHEMBL4546202)
Affinity DataEC50:  0.383nMAssay Description:Agonist activity at human TLR2 expressed in HEK-Blue cells co-expressing NF-kappaB-SEAP reporter gene measured after 16 hrs by SEAP reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358537(CHEMBL1923536)
Affinity DataEC50:  0.450nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50526710(CHEMBL4560927)
Affinity DataEC50:  0.468nMAssay Description:Agonist activity at human TLR2 expressed in HEK-Blue cells co-expressing NF-kappaB-SEAP reporter gene measured after 16 hrs by SEAP reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50552140(CHEMBL4780449)
Affinity DataEC50:  0.470nMAssay Description:Agonist activity at TLR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358542(CHEMBL1923541)
Affinity DataEC50:  0.560nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50526713(CHEMBL4461230)
Affinity DataEC50:  0.609nMAssay Description:Agonist activity at human TLR2 expressed in HEK-Blue cells co-expressing NF-kappaB-SEAP reporter gene measured after 16 hrs by SEAP reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358539(CHEMBL1923538)
Affinity DataEC50:  0.870nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358538(CHEMBL1923537)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50386534(CHEMBL2048075 | US9676818, 11d)
Affinity DataEC50:  1.01nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NFkappaB translocation after 12 hrs by secretory alkaline phosphatase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50526719(CHEMBL4537583)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human TLR2 expressed in HEK-Blue cells co-expressing NF-kappaB-SEAP reporter gene measured after 16 hrs by SEAP reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358543(CHEMBL1923542)
Affinity DataEC50:  1.47nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358546(CHEMBL1923545)
Affinity DataEC50:  1.55nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50386538(CHEMBL2048076 | US9676818, 11e)
Affinity DataEC50:  1.64nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NFkappaB translocation after 12 hrs by secretory alkaline phosphatase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358549(CHEMBL1923548)
Affinity DataEC50:  1.86nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358548(CHEMBL1923547)
Affinity DataEC50:  1.95nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358545(CHEMBL1923544)
Affinity DataEC50:  2.11nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358547(CHEMBL1923546)
Affinity DataEC50:  3.23nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358550(CHEMBL1923549 | US9676818, 6d)
Affinity DataEC50:  3.63nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NFkappaB translocation after 12 hrs by secretory alkaline phosphatase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50399457(CHEMBL2179400)
Affinity DataEC50:  3.70nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as induction of NF-kappaB signaling after 24 hrs by luminescence based luciferase r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50386537(CHEMBL2048077 | US9676818, 11f)
Affinity DataEC50:  3.80nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NFkappaB translocation after 12 hrs by secretory alkaline phosphatase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50526716(CHEMBL4582174)
Affinity DataEC50:  4.40nMAssay Description:Agonist activity at human TLR2 expressed in HEK-Blue cells co-expressing NF-kappaB-SEAP reporter gene measured after 16 hrs by SEAP reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50406593(CHEMBL5278184)
Affinity DataEC50:  4.40nMAssay Description:Agonist activity at human TLR2 transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358550(CHEMBL1923549 | US9676818, 6d)
Affinity DataEC50:  4.44nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50386535(CHEMBL2048219 | US9676818, 11h)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NFkappaB translocation after 12 hrs by secretory alkaline phosphatase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50386539(CHEMBL2048067 | US9676818, 6e)
Affinity DataEC50:  4.79nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NFkappaB translocation after 12 hrs by secretory alkaline phosphatase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 1/2(Human)
Southern Medical University

US Patent
LigandPNGBDBM50552134(CHEMBL4759149 | US11472815, Compound 22)
Affinity DataEC50:  4.88nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50552134(CHEMBL4759149 | US11472815, Compound 22)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at TLR2 in HEK-Blue hTLR2 cells assessed as NF-kappaB activation preincubated for 24 hrs followed by replacement of medium containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 1/2(Human)
Southern Medical University

US Patent
LigandPNGBDBM577391(US11472815, Compound 23)
Affinity DataEC50:  5.14nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50386536(CHEMBL2048220 | US9676818, 16)
Affinity DataEC50:  5.52nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NFkappaB translocation after 12 hrs by secretory alkaline phosphatase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50406462(CHEMBL5284309)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at human TLR2 transfected in HEK293 cells relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50406462(CHEMBL5284309)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at human TLR2 transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50358541(CHEMBL1923540)
Affinity DataEC50:  6.48nMAssay Description:Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50399454(CHEMBL2179401)
Affinity DataKi:  11nMAssay Description:Displacement of Eu-DTPA from human TLR2 expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 1/2(Human)
Southern Medical University

US Patent
LigandPNGBDBM577407(US11472815, Compound 39)
Affinity DataEC50:  12nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50406552(CHEMBL5283567)
Affinity DataEC50:  14nMAssay Description:Agonist activity at human TLR2 transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50511993(CHEMBL4472879)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human TLR2 expressed in HEK-Blue hTLR2 cells as SEAP expression incubated for 16 hrs by SEAP-based plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50406601(CHEMBL5276854)
Affinity DataKi:  16nMAssay Description:Binding affinity to TLR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetToll-like receptor 1/2(Human)
Southern Medical University

US Patent
LigandPNGBDBM577406(US11472815, Compound 38)
Affinity DataEC50:  16.9nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50526715(CHEMBL4585276)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human TLR2 expressed in HEK-Blue cells co-expressing NF-kappaB-SEAP reporter gene measured after 16 hrs by SEAP reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetToll-like receptor 1/2(Human)
Southern Medical University

US Patent
LigandPNGBDBM577403(US11472815, Compound 35)
Affinity DataEC50:  18.8nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50406556(CHEMBL5266345)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human TLR2 transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetToll-like receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50406599(CHEMBL5276410)
Affinity DataEC50:  20nMAssay Description:Agonist activity at TLR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
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