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TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633261(US20190276450, Example 1)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633263(US20190276450, Example 1.2)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633266(US20190276450, Example 1b.2)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633268(US20190276450, Example 1b.4)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633269(US20190276450, Example 1b.5)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633270(US20190276450, Example 1b.6)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633271(US20190276450, Example 2)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633273(US20190276450, Example 2.2)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633280(US20190276450, Example 2.8)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633283(US20190276450, Example 2.11)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633286(US20190276450, Example 2a.3)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633288(US20190276450, Example 3)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633289(US20190276450, Example 3.2)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633293(US20190276450, Example 4.3)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633298(US20190276450, Example 6)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633301(US20190276450, Example 7)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633303(US20190276450, Example 9)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633304(US20190276450, Example 10)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633305(US20190276450, Example 11)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633308(US20190276450, Example 12)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633310(US20190276450, Example 12.3)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633313(US20190276450, Example 12.6)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633324(US20190276450, Example 14.4)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633325(US20190276450, Example 14.5)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633326(US20190276450, Example 14.6)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633332(US20190276450, Example 17)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633335(US20190276450, Example 17.2)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633344(US20190276450, Example 21)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633347(US20190276450, Example 22)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633348(US20190276450, Example 22a)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633349(US20190276450, Example 22.2)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633350(US20190276450, Example 22.4 | US20190276450, Examp...)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633350(US20190276450, Example 22.4 | US20190276450, Examp...)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633352(US20190276450, Example 22.5)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633353(US20190276450, Example 22.6)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633355(US20190276450, Example 22.8)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633357(US20190276450, Example 22.10)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633359(US20190276450, Example 24)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633360(US20190276450, Example 25)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633361(US20190276450, Example 26)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  4.80nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM374714(US10246466, Example 39 | 12-chloro-11-fluoro-14-me...)
Affinity DataKd:  27nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM374716(US10246466, Example 41 | 10-fluoro-8-methyl-15,16-...)
Affinity DataKd:  2.60nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM374718(US10246466, Example 43 | 14-ethyl-11-fluoro-6,7,13...)
Affinity DataKd:  3.70nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM374719(US10246466, Example 45 | 11-fluoro-14-(propan-2-yl...)
Affinity DataKd:  7.80nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM374720(US10246466, Example 49 | 14-methyl-6,7,13,14-tetra...)
Affinity DataKd:  24nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM374721(US10246466, Example 50 | 11-fluoro-6,7,13,14-tetra...)
Affinity DataKd:  0.570nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM374722(US10246466, Example 51 | 11-fluoro-13-methyl-6,7,1...)
Affinity DataKd:  0.150nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM374723(US10246466, Example 51-1 | (13R)-11-fluoro-13-meth...)
Affinity DataKd:  0.0480nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

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