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TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKi:  1.70E+6nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKi:  8.90E+5nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.89E+3nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50463484(CHEMBL4248525)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of MSK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50463483(CHEMBL4245242)
Affinity DataKi:  990nMAssay Description:Inhibition of MSK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi:  100nMAssay Description:Inhibition of p70S6K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi:  94nMAssay Description:Inhibition of MSK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM30185(CHEMBL226403 | Pyrrolopyridine, 16)
Affinity DataIC50: 2.00E+5nMAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM30192(Pyrrolopyridine, 23)
Affinity DataIC50: 2.00E+5nMAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50215481(5-methoxy-9,12-diazatetracyclo[10.2.1.0^{2,10}.0^{...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50215483(6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM30178(Pyrrolopyridine, 9)
Affinity DataIC50: 1.46E+5nMAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50537742(CHEMBL4634634 | US11179389, Compound 1-14)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant full length human GST-tagged RPS6KA5 expressed in baculovirus expression system using ser/Thr01 peptide as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50601160(CHEMBL5187801)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human MSK1 (2 to end residues) expressed in baculovirus infected Sf21 insect cells using FAM-PSKPAAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50601160(CHEMBL5187801)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human MSK1 (2 to end residues) expressed in baculovirus infected Sf21 insect cells using FAM-PSKPAAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50374608(CHEMBL410295)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MSK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM24466(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337134(US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...)
Affinity DataIC50: 5.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337134(US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...)
Affinity DataIC50: 5.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337134(US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...)
Affinity DataIC50: 5.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50601144(CHEMBL5170774)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50601148(CHEMBL5178920)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50601149(CHEMBL5171875)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50601150(CHEMBL5208900)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50601155(CHEMBL5187497)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50586589(SR-302)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of RPS6KA5 (unknown origin) expressed in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50194671(4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(2-(...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of MSK1 by HTRF kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50194668(4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of MSK1 by HTRF kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50326208(4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of MSK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50601143(CHEMBL5188277)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50601151(CHEMBL5193264)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50601154(CHEMBL5190893)
Affinity DataIC50: 1.78E+4nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50151347(2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-n...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of MSK-1 kinase binding in fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM25003(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminoprop...)
Affinity DataIC50: 1.59E+4nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2008
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50601160(CHEMBL5187801)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of N-terminal His-Smt-tagged MSK1 C-terminal kinase domain (414 to 738 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50601159(CHEMBL5178745)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM236557(US9365572, 5)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Agents: 1-fold kinase buffer without MnCl2: 50 mM HEPES, pH 7.5, 0.0015% Brij-35, 10 mM MgCl2, 2 mM DTT. 1-fold kinase buffer with MnCl2: 50 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50462709(CHEMBL4245507)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MSK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50499634(CHEMBL3741589)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MSK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MSK1 (2 to end residues) using GRPRTSSFAEGKK as substrate incubated for 40 mins in presence of [gamma-33ATP by radiom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50573869(CHEMBL4556790)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MSK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50147463(3-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-4-[1-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MSK-1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50168574(1-Ethyl-2-furan-3-yl-1H-imidazo[4,5-c]pyridine | C...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration exhibited towards MSK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50168573(3-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-pyridin-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration exhibited towards MSK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50168575(1-Ethyl-2-pyridin-3-yl-1H-imidazo[4,5-c]pyridine |...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration exhibited towards MSK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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