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Report error Found 1525 of affinity data for UniProtKB/TrEMBL: O76083
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 114730BDBM114730(6-[methyl(1- pyrimidin-2- ylpropyl)amino]- 4-oxo-1...)
Affinity DataKi:  0.0100nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2026
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484541BDBM484541(US10934294, Example 62 | US11028092, Example 63)
Affinity DataKi:  0.0100nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484529BDBM484529(US10934294, Example 57 | US10934294, Example 56 | ...)
Affinity DataKi:  0.0100nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484570BDBM484570(US10934294, Example 92 | US10934294, Example 91 | ...)
Affinity DataKi:  0.0100nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484529BDBM484529(US10934294, Example 57 | US10934294, Example 56 | ...)
Affinity DataKi:  0.0100nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484497BDBM484497(US10934294, Example 22 | US10934294, Example 21 | ...)
Affinity DataKi:  0.0100nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 114733BDBM114733(6-[1-[5- (difluoromethyl) pyrimidin-2- yl]propyl- ...)
Affinity DataKi:  0.0100nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2026
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484497BDBM484497(US10934294, Example 22 | US10934294, Example 21 | ...)
Affinity DataKi:  0.0100nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484541BDBM484541(US10934294, Example 62 | US11028092, Example 63)
Affinity DataKi:  0.0100nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484570BDBM484570(US10934294, Example 92 | US10934294, Example 91 | ...)
Affinity DataKi:  0.0100nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484551BDBM484551(US10934294, Example 75 | US10934294, Example 74 | ...)
Affinity DataKi:  0.0200nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 114793BDBM114793(1-[1-(4-cyclo- propylphenyl) ethyl]-6-[1-(5- fluor...)
Affinity DataKi:  0.0200nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484551BDBM484551(US10934294, Example 75 | US10934294, Example 74 | ...)
Affinity DataKi:  0.0200nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484573BDBM484573(US10934294, Example 94 | US11028092, Example 93)
Affinity DataKi:  0.0300nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 114787BDBM114787(1-[1-(6- cyclopropyl-3- pyridyl)ethyl]- 6-[1-(5- f...)
Affinity DataKi:  0.0300nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2026
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 114719BDBM114719(US20260001888, Example 4)
Affinity DataKi:  0.0300nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484572BDBM484572(US10934294, Example 93)
Affinity DataKi:  0.0300nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 726413BDBM726413(4-oxo-6-(2-(pyridin- 2-yl)cyclobutyl)-1- ((S)-1-(6...)
Affinity DataKi:  0.0340nMAssay Description:Assays were performed at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. Solutions of test compounds were prepar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/15/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484596BDBM484596(US10934294, Example 114 | US11028092, Example 114)
Affinity DataKi:  0.0400nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484509BDBM484509(US10934294, Example 33 | US10934294, Example 32 | ...)
Affinity DataKi:  0.0400nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484593BDBM484593(US10934294, Example 111)
Affinity DataKi:  0.0400nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484596BDBM484596(US10934294, Example 114 | US11028092, Example 114)
Affinity DataKi:  0.0400nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484509BDBM484509(US10934294, Example 33 | US10934294, Example 32 | ...)
Affinity DataKi:  0.0400nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 502801BDBM502801(US11028092, Example 111)
Affinity DataKi:  0.0400nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484591BDBM484591(US10934294, Example 110 | US11028092, Example 110)
Affinity DataKi:  0.0500nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484591BDBM484591(US10934294, Example 110 | US11028092, Example 110)
Affinity DataKi:  0.0500nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484539BDBM484539(US10934294, Example 61 | US10934294, Example 60 | ...)
Affinity DataKi:  0.0800nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484539BDBM484539(US10934294, Example 61 | US10934294, Example 60 | ...)
Affinity DataKi:  0.0800nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484559BDBM484559(US10934294, Example 81 | US10934294, Example 80 | ...)
Affinity DataKi:  0.0900nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484559BDBM484559(US10934294, Example 81 | US10934294, Example 80 | ...)
Affinity DataKi:  0.0900nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484501BDBM484501(US10934294, Example 26 | US10934294, Example 25 | ...)
Affinity DataKi:  0.100nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 711677BDBM711677(US12187729, Example 28)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of the representative compounds according to the present invention against phosphodiesterase 9A was tested based on the polar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 711694BDBM711694(US12187729, Example 45)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of the representative compounds according to the present invention against phosphodiesterase 9A was tested based on the polar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484489BDBM484489(US10934294, Example 14 | US10934294, Example 13 | ...)
Affinity DataKi:  0.100nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484484BDBM484484(US10934294, Example 6 | US11028092, Example 6)
Affinity DataKi:  0.100nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484501BDBM484501(US10934294, Example 26 | US10934294, Example 25 | ...)
Affinity DataKi:  0.100nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484484BDBM484484(US10934294, Example 6 | US11028092, Example 6)
Affinity DataKi:  0.100nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484489BDBM484489(US10934294, Example 14 | US10934294, Example 13 | ...)
Affinity DataKi:  0.100nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 711680BDBM711680(US12187729, Example 31)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of the representative compounds according to the present invention against phosphodiesterase 9A was tested based on the polar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 711696BDBM711696(US12187729, Example 47)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of the representative compounds according to the present invention against phosphodiesterase 9A was tested based on the polar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 726423BDBM726423(6-(2-(5-fluoropyridin- 2-yl)cyclobutyl)-4- oxo-1-(...)
Affinity DataKi:  0.120nMAssay Description:Assays were performed at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. Solutions of test compounds were prepar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/15/2025
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484537BDBM484537(US10934294, Example 59 | US10934294, Example 58 | ...)
Affinity DataKi:  0.120nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484537BDBM484537(US10934294, Example 59 | US10934294, Example 58 | ...)
Affinity DataKi:  0.120nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484517BDBM484517(US10934294, Example 45 | US10934294, Example 44 | ...)
Affinity DataKi:  0.130nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484517BDBM484517(US10934294, Example 45 | US10934294, Example 44 | ...)
Affinity DataKi:  0.130nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484594BDBM484594(BDBM502802 | US10934294, Example 112)
Affinity DataKi:  0.130nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 484594BDBM484594(BDBM502802 | US10934294, Example 112)
Affinity DataKi:  0.130nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 114725BDBM114725(6-[methyl(1- pyrimidin-2- ylpropyl)amino]- 4-oxo-1...)
Affinity DataKi:  0.140nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2026
Entry Details
US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 726435BDBM726435(6-(2-(1-methyl-1H- pyrazol-5- yl)cyclobutyl)-4- ox...)
Affinity DataKi:  0.145nMAssay Description:Assays were performed at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. Solutions of test compounds were prepar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/15/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 484542BDBM484542(US10934294, Example 97 | US10934294, Example 63 | ...)
Affinity DataKi:  0.150nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

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