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Report error Found 884 of affinity data for UniProtKB/TrEMBL: P14174
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652792BDBM50652792(CHEMBL3752910)
Affinity DataKd:  1.90nMAssay Description:Binding affinity to human MIF incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648297BDBM648297(US11884682, Compound 31 | 1-(3-methoxy-4-(((5-(thi...)
Affinity DataIC50: 6.92nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648295BDBM648295(US11884682, Compound 29 | 3'-methoxy-4'-((5-(thiop...)
Affinity DataIC50: 7.24nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50327348BDBM50327348(3-(3-hydroxybenzyl)-6-methylbenzo[d]oxazol-2(3H)-o...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648298BDBM648298(US11884682, Compound 32 | 2-((3-metboxy-4-((5-(thi...)
Affinity DataIC50: 9.55nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50327346BDBM50327346(3-(3-hydroxybenzyl)-5-methylbenzo[d]oxazol-2(3H)-o...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648281BDBM648281(US11884682, Compound 17 | 4-(2-hydroxyethoxy)-2-me...)
Affinity DataIC50: 10.5nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648291BDBM648291(US11884682, Compound 26 | 4-(3-(2H-tetrazol-5-yl)p...)
Affinity DataIC50: 11.2nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648286BDBM648286(US11884682, Compound 22 | 4-((2H-tetrazol-5-yl)met...)
Affinity DataIC50: 12.3nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648296BDBM648296(US11884682, Compound 30 | (3-methoxy-4-((5-(thioph...)
Affinity DataIC50: 12.6nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206092BDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  14nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as borate-enol complex formation using 4-hydroxypheny...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206092BDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  14nMAssay Description:Inhibition of recombinant human MIF tautomerase activity using 4-hydroxyphenyl pyruvic acid (HPP) as substrate pre-incubated for 30 mins and followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50553887BDBM50553887(CHEMBL4779696)
Affinity DataKd:  16nMAssay Description:Binding affinity to C-terminal His-tagged recombinant human MIF expressed in Escherichia coli BL21 (DE3) at 200 nM by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648293BDBM648293(US11884682, Compound 27 | Cis-4-(3-methoxy-4-((5-(...)
Affinity DataIC50: 18.6nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648260BDBM648260(US11884682, Compound 5 | 2,4-dimethoxy-N-(5-(thiop...)
Affinity DataIC50: 18.6nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648289BDBM648289(US11884682, Compound 25 | 4-(3-cyanopropyl)-2-meth...)
Affinity DataIC50: 20.9nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648267BDBM648267(US11884682, Compound 9 | 2,4-dimethoxy-N-(5-(thiop...)
Affinity DataIC50: 22.9nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206092BDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  23nMAssay Description:Data obtained for the Example compounds, obtained using the methods described in Example B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206092BDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  23nMAssay Description:Inhibition of the tautomerase activity of MIF was measured using 4-hydroxyphenyl pyruvic acid (HPP) as substrate, largely following previously report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648282BDBM648282(US11884682, Compound 18 | 4-(2-(benzyloxy)ethoxy)-...)
Affinity DataIC50: 23.4nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206091BDBM50206091(CHEMBL3918231 | US10336721, Example 25 | US1096819...)
Affinity DataKi:  24nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as borate-enol complex formation using 4-hydroxypheny...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2018
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648285BDBM648285(US11884682, Compound 21 | 2-(3-methoxy-4-((5-(thio...)
Affinity DataIC50: 25.7nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648283BDBM648283(US11884682, Compound 19 | 2-(3-methoxy-4-((5-(thio...)
Affinity DataIC50: 28.8nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648287BDBM648287(US11884682, Compound 23 | 2-methoxy-4-((2-((5-meth...)
Affinity DataIC50: 31.6nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206083BDBM50206083(CHEMBL3927658 | US10968198, Example 43)
Affinity DataKi:  34nMAssay Description:Data obtained for the Example compounds, obtained using the methods described in Example B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 403784BDBM403784(US10336721, Example 43)
Affinity DataKi:  34nMAssay Description:Inhibition of the tautomerase activity of MIF was measured using 4-hydroxyphenyl pyruvic acid (HPP) as substrate, largely following previously report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648303BDBM648303(US11884682, Compound 37 | 2-methoxy-4-morpholino-N...)
Affinity DataIC50: 36.3nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206062BDBM50206062(CHEMBL3890541 | US10968198, Example 44)
Affinity DataKi:  37nMAssay Description:Inhibition of recombinant human MIF tautomerase activity using 4-hydroxyphenyl pyruvic acid (HPP) as substrate pre-incubated for 30 mins and followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206062BDBM50206062(CHEMBL3890541 | US10968198, Example 44)
Affinity DataKi:  37nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as borate-enol complex formation using 4-hydroxypheny...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2018
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50095997BDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataKi:  38nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50095997BDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataKi:  38nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50095997BDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataIC50: 38nMAssay Description:Inhibition of human MIF tautomerase activity expressed in Escherichia coli BL21 (DE3) using 4-hydroxyphenyl pyruvic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313986BDBM50313986(3-(3,4-dihydroxyphenyl)-4H-chromen-4-one | CHEMBL1...)
Affinity DataIC50: 38nMAssay Description:Inhibition of MIFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50095997BDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant human His-tagged MIF tautomerization expressed in Escherichia coli BL21 (DE3) using D-dopachrome as substrate after 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648294BDBM648294(US11884682, Compound 28 | Trans-4-(3-methoxy-4-((5...)
Affinity DataIC50: 38nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206083BDBM50206083(CHEMBL3927658 | US10968198, Example 43)
Affinity DataKi:  39nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2020
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206083BDBM50206083(CHEMBL3927658 | US10968198, Example 43)
Affinity DataKi:  39nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as borate-enol complex formation using 4-hydroxypheny...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2018
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 490115BDBM490115(US10968198, Example 42)
Affinity DataKi:  43nMAssay Description:Data obtained for the Example compounds, obtained using the methods described in Example B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 403783BDBM403783(US10336721, Example 42)
Affinity DataKi:  43nMAssay Description:Inhibition of the tautomerase activity of MIF was measured using 4-hydroxyphenyl pyruvic acid (HPP) as substrate, largely following previously report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206062BDBM50206062(CHEMBL3890541 | US10968198, Example 44)
Affinity DataKi:  45nMAssay Description:Data obtained for the Example compounds, obtained using the methods described in Example B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 403785BDBM403785(US10336721, Example 44)
Affinity DataKi:  45nMAssay Description:Inhibition of the tautomerase activity of MIF was measured using 4-hydroxyphenyl pyruvic acid (HPP) as substrate, largely following previously report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648300BDBM648300(US11884682, Compound 34 | 2-methoxy-4-morpholino-N...)
Affinity DataIC50: 46.8nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206084BDBM50206084(CHEMBL3899123)
Affinity DataKi:  48nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as borate-enol complex formation using 4-hydroxypheny...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2018
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206084BDBM50206084(CHEMBL3899123)
Affinity DataKi:  48nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2020
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648288BDBM648288(US11884682, Compound 24 | 2-methoxy-4-((1-((5-meth...)
Affinity DataIC50: 49nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326574BDBM50326574(6-phenylpyridazin-3-yl thiophene-2-carboxylate | C...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human MIF tautomerase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326574BDBM50326574(6-phenylpyridazin-3-yl thiophene-2-carboxylate | C...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50646210BDBM50646210(CHEMBL5591863)
Affinity DataKi:  51nMAssay Description:Binding affinity to MIF in human A549 cells assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 648299BDBM648299(US11884682, Compound 33 | 4-(6-oxa-3-azabicyclo[3....)
Affinity DataIC50: 51.3nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 92515BDBM92515(RDR 03785, 11)
Affinity DataKi:  52nMAssay Description:Covalent inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli using 4-hydroxyphenyl pyruvic acid as substrate asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2017
Entry Details Article
PubMed
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