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TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254063(CHEMBL4102000)
Affinity DataIC50: 0.0940nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230986(Carperitide | SUN-4936)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452476(CHEMBL4206902)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50262475(CHEMBL4090153)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50091751(Cyclic-(Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Al...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50091758((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50091752((S)-3-{(2S,3S)-2-[(S)-5-Guanidino-2-(2-{4-[(naphth...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50091757(Cyclic-(Cys-Phe-Gly-Gly-Ala-Ile-Asp-Arg-Ile-Gly-Al...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50091753(H-Ser-Leu-Arg-Arg-Ser-Ser-cyclic(Cys-Phe-Gly-Gly-A...)
Affinity DataKi:  0.650nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50112321(mintANP | Atrial natriuretic peptide analogue | CH...)
Affinity DataEC50:  0.680nMAssay Description:Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230984(CHEMBL4099832)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50112320(Atrial natriuretic peptide analogue | [Pro7]mintAN...)
Affinity DataEC50:  4.90nMAssay Description:Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230983(CHEMBL4061575)
Affinity DataEC50:  5.80nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50333671(CHEMBL1643388)
Affinity DataIC50: 6nMAssay Description:Displacement of [125I]ANP from NPR-A expressed in HeLa cells after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230988(CHEMBL4089697)
Affinity DataEC50:  8.10nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50112316(Atrial natriuretic peptide analogue | CHEMBL384862)
Affinity DataEC50:  8.30nMAssay Description:Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50091754(Arg-Ser-Ser-cyclic-(Cys-Phe-Gly-Gly-Arg-Ile-Asp-Ar...)
Affinity DataKi: >10nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50091761((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi: >10nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230982(CHEMBL4097422)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50112317([Ala7]mintANP | Atrial natriuretic peptide analogu...)
Affinity DataEC50:  30nMAssay Description:Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452475(CHEMBL4218179)
Affinity DataEC50:  41nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50112318(Atrial natriuretic peptide analogue | CHEMBL409400)
Affinity DataEC50:  47nMAssay Description:Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50333672(CHEMBL1643389)
Affinity DataIC50: 60nMAssay Description:Displacement of [125I]ANP from NPR-A expressed in HeLa cells after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50091759(Naphthalene-2-carboxylic acid (4-{[(S)-4-guanidino...)
Affinity DataKi:  62nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50091747((S)-N-[(S)-1-((S)-2-Methyl-butylcarbamoyl)-ethyl]-...)
Affinity DataKi:  65nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50112323(Atrial natriuretic peptide analogue | CHEMBL414517)
Affinity DataEC50:  66nMAssay Description:Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452457(CHEMBL4213559)
Affinity DataEC50:  71nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50262473(CHEMBL4071795)
Affinity DataEC50:  73nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452458(CHEMBL4207138)
Affinity DataEC50:  78nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50091750(Cyclic-(Cys-Phe-Gly-Gly-Arg-Ile-Ala-Arg-Ile-Gly-Al...)
Affinity DataKi:  87nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452455(CHEMBL4215510)
Affinity DataEC50:  98nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1/2/3(Human)
G. D. Searle

Curated by ChEMBL
LigandPNGBDBM50228173(CHEMBL2371607)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against guanylate cyclase coupled receptor binding site in rabbit lung by using [125I]-ANP-(103-126)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50112326(Atrial natriuretic peptide analogue | CHEMBL413653)
Affinity DataEC50:  108nMAssay Description:Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452456(CHEMBL4206652)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254098(CHEMBL4098363)
Affinity DataIC50: 120nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50262458(CHEMBL4073156)
Affinity DataEC50:  170nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50112322(Atrial natriuretic peptide analogue | CHEMBL385216)
Affinity DataEC50:  177nMAssay Description:Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50112324(Atrial natriuretic peptide analogue | CHEMBL408343)
Affinity DataEC50:  198nMAssay Description:Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452473(CHEMBL4205804)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50112325(Atrial natriuretic peptide analogue | CHEMBL402664)
Affinity DataEC50:  215nMAssay Description:Production of c-GMP in CHO cells expressing natriuretic peptide receptor (NPR-A) in response to compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452451(CHEMBL4210772)
Affinity DataEC50:  220nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50262472(CHEMBL4077093)
Affinity DataEC50:  220nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50333673(CHEMBL1643390)
Affinity DataIC50: 240nMAssay Description:Displacement of [125I]ANP from NPR-A expressed in HeLa cells after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50262474(CHEMBL4082303)
Affinity DataEC50:  260nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50262485(CHEMBL4098800)
Affinity DataEC50:  310nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452464(CHEMBL4212125)
Affinity DataEC50:  320nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452467(CHEMBL4218032)
Affinity DataEC50:  320nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452470(CHEMBL4207573)
Affinity DataEC50:  330nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452469(CHEMBL4210169)
Affinity DataEC50:  340nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50091749(Cyclic-(Cys-Phe-Gly-Gly-Arg-Ala-Asp-Arg-Ile-Gly-Al...)
Affinity DataKi:  360nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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