Compile Data Set for Download or QSAR
Report error Found 1459 of affinity data for UniProtKB/TrEMBL: P17706
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663643BDBM50663643(CHEMBL6167017)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 679453BDBM679453(US20240180886, Example 51 | 5-(2-fluoro-6- hydroxy...)
Affinity DataIC50: 0.200nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50649516BDBM50649516(CHEMBL5619806)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of PTPN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663674BDBM50663674(CHEMBL6177218)
Affinity DataIC50: 0.580nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50649516BDBM50649516(CHEMBL5619806)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50579998BDBM50579998(CHEMBL5084112)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50579999BDBM50579999(CHEMBL5075269)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580000BDBM50580000(CHEMBL5076419)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580001BDBM50580001(CHEMBL5087544)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 679403BDBM679403(US20240180886, Example 1 | 5-(4-(((4- cyclopropylp...)
Affinity DataIC50: 1nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663673BDBM50663673(Tegeprotafib)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580002BDBM50580002(CHEMBL5084380)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580003BDBM50580003(CHEMBL5080612)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663675BDBM50663675(CHEMBL6171763)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580005BDBM50580005(CHEMBL5093253)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663643BDBM50663643(CHEMBL6167017)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663644BDBM50663644(CHEMBL6175327)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663642BDBM50663642(CHEMBL6175073)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 679407BDBM679407(US20240180886, Example 5 | 5-(4-(((4,6- dimethylpy...)
Affinity DataIC50: 1nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 679430BDBM679430(US20240180886, Example 28 | 5-(4-(((4,5- dimethylp...)
Affinity DataIC50: 1nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 682039BDBM682039(US20240207238, Example 9)
Affinity DataIC50: 1nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50579994BDBM50579994(CHEMBL5070507)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50579995BDBM50579995(CHEMBL5085502)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50579996BDBM50579996(CHEMBL5092308)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50579997BDBM50579997(CHEMBL5085615)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 778039BDBM778039(5-[2-fluoro-6-hydroxy- 4-[(4-hydroxy-5-methyl- pyr...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 778044BDBM778044(5-[2-fluoro-6-hydroxy- 4-[(4-hydroxy-5- isobutyl-p...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 778043BDBM778043(5-[2-fluoro-6-hydroxy- 4-[(4-hydroxy-6-methyl- pyr...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 679419BDBM679419(US20240180886, Example 17 | 5-(2-fluoro-6- hydroxy...)
Affinity DataIC50: 1nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 682034BDBM682034(US20240207238, Example 4)
Affinity DataIC50: 1nMAssay Description:A PhosphoSens kinase assay was performed as described by the vendor (AssayQuant Technologies, Marlborough, MA). Briefly, 1000x solutions of compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 679407BDBM679407(US20240180886, Example 5 | 5-(4-(((4,6- dimethylpy...)
Affinity DataIC50: 1nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 682039BDBM682039(US20240207238, Example 9)
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663678BDBM50663678(CHEMBL6176656)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 736420BDBM736420(US20250134882, Example 4)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PTPN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 736420BDBM736420(US20250134882, Example 4)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of full-length human recombinant PTPN2 incubated for 20 mins by mobile shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 736420BDBM736420(US20250134882, Example 4)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human PTPN2 extracted from Escherichia coli BL21 (DE3) by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 679415BDBM679415(US20240180886, Example 13 | 5-(4-(((4- ethylpyridi...)
Affinity DataIC50: 2nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219584BDBM50219584(5-{3-[(1-{[2-(acetylamino)benzyl]sulfonyl}piperidi...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 679430BDBM679430(US20240180886, Example 28 | 5-(4-(((4,5- dimethylp...)
Affinity DataIC50: 2nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219586BDBM50219586(4-bromo-3-(carboxymethoxy)-5-{3-[(1-{[2-(trifluoro...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219588BDBM50219588(4-bromo-3-(carboxymethoxy)-5-(3-{[1-({2-[(methylsu...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219577BDBM50219577(5-[3-({1-[(2-aminobenzyl)sulfonyl]piperidin-4-yl}a...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 682031BDBM682031(US20240207238, Example 1)
Affinity DataIC50: 2nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 679443BDBM679443(US20240180886, Example 41 | 5-(2-fluoro-6- hydroxy...)
Affinity DataIC50: 2nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50649520BDBM50649520(CHEMBL5618445 | US20250257059, Example 110)
Affinity DataIC50: 2nMAssay Description:Inhibition of PTPN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 679443BDBM679443(US20240180886, Example 41 | 5-(2-fluoro-6- hydroxy...)
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 682034BDBM682034(US20240207238, Example 4)
Affinity DataIC50: 2nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 679421BDBM679421(US20240180886, Example 19 | 5-(4-(((5,6- dimethylp...)
Affinity DataIC50: 2nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 736420BDBM736420(US20250134882, Example 4)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human PTPN2 using DiFMUP as substrate by fluorescence based phosphatase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Fudan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 723257BDBM723257(US20250059220, Compound 369)
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
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