Compile Data Set for Download or QSAR
Report error Found 1326 of affinity data for UniProtKB/TrEMBL: P17706
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679453BDBM679453(US20240180886, Example 51 | 5-(2-fluoro-6- hydroxy...)
Affinity DataIC50: 0.200nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50649516BDBM50649516(CHEMBL5619806)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of PTPN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50579998BDBM50579998(CHEMBL5084112)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50579999BDBM50579999(CHEMBL5075269)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50580000BDBM50580000(CHEMBL5076419)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50580001BDBM50580001(CHEMBL5087544)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679403BDBM679403(US20240180886, Example 1 | 5-(4-(((4- cyclopropylp...)
Affinity DataIC50: 1nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50580002BDBM50580002(CHEMBL5084380)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50580003BDBM50580003(CHEMBL5080612)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50580005BDBM50580005(CHEMBL5093253)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679419BDBM679419(US20240180886, Example 17 | 5-(2-fluoro-6- hydroxy...)
Affinity DataIC50: 1nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 682034BDBM682034(US20240207238, Example 4)
Affinity DataIC50: 1nMAssay Description:A PhosphoSens kinase assay was performed as described by the vendor (AssayQuant Technologies, Marlborough, MA). Briefly, 1000x solutions of compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679407BDBM679407(US20240180886, Example 5 | 5-(4-(((4,6- dimethylpy...)
Affinity DataIC50: 1nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679430BDBM679430(US20240180886, Example 28 | 5-(4-(((4,5- dimethylp...)
Affinity DataIC50: 1nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 682039BDBM682039(US20240207238, Example 9)
Affinity DataIC50: 1nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679407BDBM679407(US20240180886, Example 5 | 5-(4-(((4,6- dimethylpy...)
Affinity DataIC50: 1nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50579994BDBM50579994(CHEMBL5070507)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50579995BDBM50579995(CHEMBL5085502)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50579996BDBM50579996(CHEMBL5092308)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50579997BDBM50579997(CHEMBL5085615)
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN2 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 736420BDBM736420(US20250134882, Example 4)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PTPN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 736420BDBM736420(US20250134882, Example 4)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of full-length human recombinant PTPN2 incubated for 20 mins by mobile shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 736420BDBM736420(US20250134882, Example 4)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human PTPN2 extracted from Escherichia coli BL21 (DE3) by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679415BDBM679415(US20240180886, Example 13 | 5-(4-(((4- ethylpyridi...)
Affinity DataIC50: 2nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50219584BDBM50219584(5-{3-[(1-{[2-(acetylamino)benzyl]sulfonyl}piperidi...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679430BDBM679430(US20240180886, Example 28 | 5-(4-(((4,5- dimethylp...)
Affinity DataIC50: 2nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50219586BDBM50219586(4-bromo-3-(carboxymethoxy)-5-{3-[(1-{[2-(trifluoro...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50219588BDBM50219588(4-bromo-3-(carboxymethoxy)-5-(3-{[1-({2-[(methylsu...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50219577BDBM50219577(5-[3-({1-[(2-aminobenzyl)sulfonyl]piperidin-4-yl}a...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 682031BDBM682031(US20240207238, Example 1)
Affinity DataIC50: 2nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679443BDBM679443(US20240180886, Example 41 | 5-(2-fluoro-6- hydroxy...)
Affinity DataIC50: 2nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50649520BDBM50649520(CHEMBL5618445 | US20250257059, Example 110)
Affinity DataIC50: 2nMAssay Description:Inhibition of PTPN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 682034BDBM682034(US20240207238, Example 4)
Affinity DataIC50: 2nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679421BDBM679421(US20240180886, Example 19 | 5-(4-(((5,6- dimethylp...)
Affinity DataIC50: 2nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 736420BDBM736420(US20250134882, Example 4)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human PTPN2 using DiFMUP as substrate by fluorescence based phosphatase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679412BDBM679412(US20240180886, Example 10 | 5-(4-(((5- cyclopropyl...)
Affinity DataIC50: 3nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 13599BDBM13599(CHEMBL269166 | 3-{4-[2-(1H-1,2,3-benzotriazol-1-yl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of TCPTP (unknown origin) by UV/Vis spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2017
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679408BDBM679408(US20240180886, Example 6 | 5-(4-(((4- cyclopropoxy...)
Affinity DataIC50: 3nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679409BDBM679409(US20240180886, Example 7 | 5-(2-fluoro-6- hydroxy-...)
Affinity DataIC50: 3nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 13599BDBM13599(CHEMBL269166 | 3-{4-[2-(1H-1,2,3-benzotriazol-1-yl...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 13599BDBM13599(CHEMBL269166 | 3-{4-[2-(1H-1,2,3-benzotriazol-1-yl...)
Affinity DataIC50: 3nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50649514BDBM50649514(CHEMBL5619195)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of PTPN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50649514BDBM50649514(CHEMBL5619195)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human PTPN2 extracted from Escherichia coli BL21 (DE3) by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50649514BDBM50649514(CHEMBL5619195)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of full-length human recombinant PTPN2 incubated for 20 mins by mobile shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50219575BDBM50219575(3-carboxymethoxy-5-{3-[1-(2-chlorobenzenesulfonyl)...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679419BDBM679419(US20240180886, Example 17 | 5-(2-fluoro-6- hydroxy...)
Affinity DataIC50: 4nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679411BDBM679411(US20240180886, Example 9 | 5-(2-fluoro-6- hydroxy-...)
Affinity DataIC50: 4nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 50142323BDBM50142323([(4-{2-Benzotriazol-1-yl-3-[3-bromo-4-(difluoro-ph...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 679411BDBM679411(US20240180886, Example 9 | 5-(2-fluoro-6- hydroxy-...)
Affinity DataIC50: 4nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 199180BDBM199180(US9217012, 10)
Affinity DataKi:  4.10nM ΔG°:  -47.9kJ/molepH: 7.0 T: 2°CAssay Description:PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in DMG buffer (50 mM DMG, pH 7.0, 1 mM EDTA, 150 mM NaCl, 2 mM DTT, 0.1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details
US Patent

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