Compile Data Set for Download or QSAR
Report error Found 115 of affinity data for UniProtKB/TrEMBL: P21964
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50019329BDBM50019329(CHEMBL1089318)
Affinity DataKi:  1nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315227BDBM50315227(Isopropyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]th...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315228BDBM50315228(Butyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thioph...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315220BDBM50315220((2-oxo-1,3-dioxol-4-yl)methyl 3-chloro-5,6-dihydro...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315230BDBM50315230(Methyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiop...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315221BDBM50315221((2-amino-3-methylbutanoyloxy)methyl 3-chloro-5,6-d...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315229BDBM50315229(Propyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiop...)
Affinity DataKi:  9.20nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315226BDBM50315226(Benzyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiop...)
Affinity DataKi:  10.2nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315223BDBM50315223(Butyryloxymethyl-3-chloro-5,6-dihydroxy-7-nitroben...)
Affinity DataKi:  10.6nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315222BDBM50315222(1-(Butyryloxy)ethyl-3-chloro-5,6-dihydroxy-7-nitro...)
Affinity DataKi:  16.6nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315225BDBM50315225(Isobutyryloxymethyl-3-chloro-5,6-dihydroxy-7-nitro...)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315224BDBM50315224(1-(Isobutyryloxy)ethyl-3-chloro-5,6-dihydroxy-7-ni...)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086213BDBM50086213(CHEMBL3425734)
Affinity DataIC50: 47nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791131BDBM791131(ethyl (Z)-2-cyano-3-hydroxy-3-(4-hydroxy-3-methoxy...)
Affinity DataIC50: 50nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086220BDBM50086220(CHEMBL3425735)
Affinity DataIC50: 53nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086218BDBM50086218(CHEMBL3425740)
Affinity DataIC50: 57nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086211BDBM50086211(CHEMBL3425738)
Affinity DataIC50: 61nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086211BDBM50086211(CHEMBL3425738)
Affinity DataIC50: 61nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791054BDBM791054((Z)-2-cyano-3-(3,4-dihydroxy-5- nitrophenyl)-N-((4...)
Affinity DataIC50: 80nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086219BDBM50086219(CHEMBL3425736)
Affinity DataIC50: 87nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086210BDBM50086210(CHEMBL3425739)
Affinity DataIC50: 88nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 206347BDBM206347(US9260413, Example 5)
Affinity DataIC50: 93nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791051BDBM791051((Z)-2-cyano-3-(3,4-dihydroxy-5- nitrophenyl)-3-hyd...)
Affinity DataIC50: 110nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791060BDBM791060(((Z)-2-cyano-3-(3,4-dihydroxy-5- nitrophenyl)-N-(2...)
Affinity DataIC50: 110nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791057BDBM791057((Z)-2-cyano-3-(3,4-dihydroxy-5- nitrophenyl)-N-(2-...)
Affinity DataIC50: 120nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791056BDBM791056((Z)-2-cyano-3-(3,4-dihydroxy-5- nitrophenyl)-3-hyd...)
Affinity DataIC50: 120nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791050BDBM791050((Z)-N-(2-chlorobenzyl)-2-cyano-3- (3,4-dihydroxy-5...)
Affinity DataIC50: 130nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086222BDBM50086222(CHEMBL3425732)
Affinity DataIC50: 140nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791055BDBM791055((Z)-2-cyano-N-(2-fluoro-5- (pyrimidin-4-yl)benzyl)...)
Affinity DataIC50: 140nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086221BDBM50086221(CHEMBL3425733)
Affinity DataIC50: 140nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791113BDBM791113((Z)-2-cyano-N-(3-(2- cyanophenyl)propyl)-3-(3,4- d...)
Affinity DataIC50: 150nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791058BDBM791058((Z)-2-cyano-3-(3,4-dihydroxy-5- nitrophenyl)-N-(2-...)
Affinity DataIC50: 150nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791134BDBM791134((Z)-2-(cyclopropanecarbonyl)-3-hydroxy-3-(4-hydrox...)
Affinity DataIC50: 150nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086223BDBM50086223(CHEMBL3425731)
Affinity DataIC50: 160nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791052BDBM791052((Z)-2-cyano-3-(3,4-dihydroxy-5- nitrophenyl)-N-(2-...)
Affinity DataIC50: 160nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652793BDBM50652793(CHEMBL5653589)
Affinity DataKd:  169nMAssay Description:Binding affinity to human COMT incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086215BDBM50086215(CHEMBL3425743 | US9260413, Example 3)
Affinity DataIC50: 170nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086215BDBM50086215(CHEMBL3425743 | US9260413, Example 3)
Affinity DataIC50: 170nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791049BDBM791049((Z)-2-cyano-N-(2-fluorobenzyl)-3- hydroxy-3-(4-hyd...)
Affinity DataIC50: 170nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791108BDBM791108((Z)-2-cyano-3-(3,4-dihydroxy-5- nitrophenyl)-3-hyd...)
Affinity DataIC50: 170nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791053BDBM791053((Z)-2-cyano-3-(3,4-dihydroxy-5- nitrophenyl)-N-(2-...)
Affinity DataIC50: 170nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086217BDBM50086217(CHEMBL3425741)
Affinity DataIC50: 180nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 206346BDBM206346(US9260413, Example 1)
Affinity DataIC50: 180nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086214BDBM50086214(CHEMBL3425744)
Affinity DataIC50: 200nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791112BDBM791112((Z)-N-(3-(2-chlorophenyl)propyl)- 2-cyano-3-(3,4-d...)
Affinity DataIC50: 200nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 206348BDBM206348(US9260413, Example 6)
Affinity DataIC50: 210nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791109BDBM791109((Z)-2-cyano-3-(3,4-dihydroxy-5- nitrophenyl)-3-hyd...)
Affinity DataIC50: 210nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791115BDBM791115(US20260035341, Example 5)
Affinity DataIC50: 210nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791062BDBM791062((Z)-2-cyano-3-(3,4-dihydroxy-5- nitrophenyl)-N-((7...)
Affinity DataIC50: 250nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791061BDBM791061((Z)-2-cyano-3-(3,4-dihydroxy-5- nitrophenyl)-N-(2-...)
Affinity DataIC50: 270nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2026
Entry Details
US Patent

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