Compile Data Set for Download or QSAR
Report error Found 219 of affinity data for UniProtKB/TrEMBL: P30531
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50334247((R,E)-1-(4-(2-fluorophenyl)-4-o-tolylbut-3-enyl)pi...)
Affinity DataKi:  14.8nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataKi:  17.0nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417649(CHEMBL1642396)
Affinity DataKi:  18.2nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417641(CHEMBL1642400)
Affinity DataKi:  19.1nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417627(CHEMBL1642378)
Affinity DataKi:  20.4nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417639(CHEMBL1642397)
Affinity DataKi:  21.9nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417626(CHEMBL1642376)
Affinity DataKi:  28.8nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417628(CHEMBL1642379)
Affinity DataKi:  29.5nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417631(CHEMBL1642384)
Affinity DataKi:  33.9nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417638(CHEMBL1642395)
Affinity DataKi:  38.0nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417642(CHEMBL1642401)
Affinity DataKi:  38.9nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417625(CHEMBL1642375)
Affinity DataKi:  40.7nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataKd:  41nMAssay Description:Competitive inhibition of human GAT1 expressed in COS cells assessed as reduction in [2H6]GABA uptake by measuring [2H6]GABA Kd(app) at 100 nM preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417637(CHEMBL1642394)
Affinity DataKi:  41.7nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417666(CHEMBL1642388)
Affinity DataKi:  46.8nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataKi:  48nMAssay Description:Binding affinity to human GAT1 expressed in HEK293 cells using NO71156 as unlabelled marker by LC-ESI-MS-MS based competitive MS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50368628(ABT-569 | Abbott-70569 | Abbott-70569.1 | Gabitril...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417640(CHEMBL1642398)
Affinity DataKi:  52.5nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417650(CHEMBL1642399)
Affinity DataKi:  53.7nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50518146(CHEMBL4525620)
Affinity DataKd:  56nMAssay Description:Non-competitive inhibition of human GAT1 expressed in COS cells assessed as reduction in [2H6]GABA uptake by measuring [2H6]GABA Kd(app) at 1 uM prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417629(CHEMBL1642381)
Affinity DataKi:  56.2nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50518149(CHEMBL4537310)
Affinity DataKd:  58nMAssay Description:Non-competitive inhibition of human GAT1 expressed in COS cells assessed as reduction in [2H6]GABA uptake by measuring [2H6]GABA Kd(app) at 1 uM prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417630(CHEMBL1642382)
Affinity DataKi:  58.9nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417635(CHEMBL1642391)
Affinity DataKi:  61.7nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50063498(CHEMBL3398501)
Affinity DataKi:  66nMAssay Description:Binding affinity to human GAT1 expressed in HEK293 cells using NO71156 as unlabelled marker by LC-ESI-MS-MS based competitive MS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417659(CHEMBL1642374)
Affinity DataKi:  69.2nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 70nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417665(CHEMBL1642393)
Affinity DataKi:  70.8nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50020891((R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carbo...)
Affinity DataKi:  72.4nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417663(CHEMBL1642386)
Affinity DataKi:  72.4nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417632(CHEMBL1642385)
Affinity DataKi:  77.6nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417633(CHEMBL1642387)
Affinity DataKi:  89.1nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417660(CHEMBL1642377)
Affinity DataKi:  93.3nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417620(CHEMBL1642367)
Affinity DataKi:  93.3nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417621(CHEMBL1642368)
Affinity DataKi:  102nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50518146(CHEMBL4525620)
Affinity DataKd:  112nMAssay Description:Non-competitive inhibition of human GAT1 expressed in COS cells assessed as reduction in [2H6]GABA uptake by measuring [2H6]GABA Kd(app) at 10 uM pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50003634(1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxyli...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50003634(1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxyli...)
Affinity DataIC50: 130nMAssay Description:Compound was tested for its ability to inhibit uptake of [3H]- GABA by cloned human GAT-1 transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50020891((R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carbo...)
Affinity DataIC50: 130nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417651(CHEMBL1642402)
Affinity DataKi:  138nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataKd:  147nMAssay Description:Competitive inhibition of human GAT1 expressed in COS cells assessed as reduction in [2H6]GABA uptake by measuring [2H6]GABA Kd(app) at 1 uM preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50518149(CHEMBL4537310)
Affinity DataKd:  154nMAssay Description:Non-competitive inhibition of human GAT1 expressed in COS cells assessed as reduction in [2H6]GABA uptake by measuring [2H6]GABA Kd(app) at 10 uM pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 155nMAssay Description:Inhibition of NO711 binding to human GAT1 expressed in COS cell membranes preincubated for 25 mins by LC-ESI-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417664(CHEMBL1642389)
Affinity DataKi:  158nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417618(CHEMBL1642364)
Affinity DataKi:  166nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417619(CHEMBL1642365)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50003634(1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxyli...)
Affinity DataIC50: 200nMAssay Description:Binding affinity to GAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50020882(CHEMBL103623 | 1-(4,4-Diphenyl-but-3-enyl)-1,2,5,6...)
Affinity DataIC50: 200nMAssay Description:Binding affinity to GAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50063503(CHEMBL3398499)
Affinity DataKi:  214nMAssay Description:Binding affinity to human GAT1 expressed in HEK293 cells using NO71156 as unlabelled marker by LC-ESI-MS-MS based competitive MS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50003618(CHEMBL542207 | CHEMBL77287 | 1-{2-[Bis-(4-trifluor...)
Affinity DataIC50: 260nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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