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Found 2252 of affinity data for UniProtKB/TrEMBL: P35408
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50373939(CHEMBL258332)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]PGE4 from human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50373942(CHEMBL272276)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]PGE4 from human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM190273(US9180116, 21C)
Affinity DataKi:  0.0820nM IC50:  0.220nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22° C. with 0.5 nM [3...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM190282(US9180116, 33C)
Affinity DataKi:  0.100nM IC50:  0.280nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22° C. with 0.5 nM [3...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM35847((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50335985(CHEMBL1669013 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...)
Affinity DataKi:  0.110nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM190272(US9180116, 12D)
Affinity DataKi:  0.120nM IC50:  0.320nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22° C. with 0.5 nM [3...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50372064(CHEMBL256873)
Affinity DataKi:  0.120nMAssay Description:Binding affinity to human EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50101822((Z)-7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(R)-3-hydroxy-o...)
Affinity DataKi:  0.140nM IC50:  0.380nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22° C. with 0.5 nM [3...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50335980(CHEMBL1669017 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...)
Affinity DataKi:  0.160nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50335986(2-chloro-N-(1-(4-(4,9-diethoxy-1-oxo-1H-benzo[f]is...)
Affinity DataKi:  0.160nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50335989(CHEMBL1669009 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...)
Affinity DataKi:  0.170nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50335981(3-(2-(1-(4-(4,9-diethoxy-1-oxo-1H-benzo[f]isoindol...)
Affinity DataKi:  0.180nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50333737(3-(4-(2-(2-(2-methoxyphenyl)acetamido)ethyl)phenyl...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM190270(US9180116, 9C)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50335984(CHEMBL1669018 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM190270(US9180116, 9C)
Affinity DataKi:  0.210nM IC50:  0.570nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22° C. with 0.5 nM [3...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50372051(CHEMBL269987)
Affinity DataKi:  0.210nMAssay Description:Binding affinity to human EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50335988(CHEMBL1669010 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...)
Affinity DataKi:  0.230nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50319837(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50372054(CHEMBL255527)
Affinity DataKi:  0.25nMAssay Description:Binding affinity to human EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50372052(CHEMBL218699)
Affinity DataKi:  0.270nMAssay Description:Binding affinity to human EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50372050(CHEMBL255906)
Affinity DataKi:  0.270nMAssay Description:Binding affinity to human EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM190275(US9180116, 28C | US9180116, 28H)
Affinity DataKi:  0.280nM IC50:  0.740nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22° C. with 0.5 nM [3...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50334136((S)-4-(1-(1-(biphenyl-4-ylmethyl)indoline-7-carbox...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50372065(CHEMBL272363)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to human EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50165949(C-Phenyl-N-{3-[2-((S)-5-phenyl-4-phenyl-oxazol-2-y...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of [3H]-PGE-2 binding to human prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50335990(2,6-dichloro-N-(1-(4-(4,9-diethoxy-1-oxo-1H-benzo[...)
Affinity DataKi:  0.300nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50012544(CHEMBL3260768)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50372056(CHEMBL255422)
Affinity DataKi:  0.310nMAssay Description:Binding affinity to human EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50319836(4-(1-(5-chloro-1-(4-(trifluoromethyl)benzyl)-1H-in...)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50372049(CHEMBL257255)
Affinity DataKi:  0.320nMAssay Description:Binding affinity to human EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50336003(CHEMBL1669023 | N-(4-(4,9-diethoxy-1-oxo-1H-benzo[...)
Affinity DataKi:  0.320nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50335982(2-(2-chlorophenyl)-N-(1-(4-(4,9-diethoxy-1-oxo-1H-...)
Affinity DataKi:  0.320nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50334129((S)-4-(1-(1-(3,5-dibromobenzyl)indoline-7-carboxam...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50333727(3-(4-((N-(1-(2-methoxyphenyl)cyclopropanecarbonyl)...)
Affinity DataKi:  0.330nMAssay Description:Binding affinity to EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50334130((S)-4-(1-(1-(3,4-dichlorobenzyl)indoline-7-carboxa...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50335983(2-(2,4-dichlorophenyl)-N-(1-(4-(4,9-diethoxy-1-oxo...)
Affinity DataKi:  0.340nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50335993(CHEMBL1669005 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...)
Affinity DataKi:  0.340nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50319837(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting in presence of 10%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50372062(CHEMBL272498)
Affinity DataKi:  0.360nMAssay Description:Binding affinity to human EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50334133((S)-4-(1-(1-(4-(trifluoromethyl)benzyl)indoline-7-...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50334149((S)-4-(1-(5-fluoro-1-(4-(trifluoromethyl)benzyl)in...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50372073(CHEMBL256220)
Affinity DataKi:  0.370nMAssay Description:Binding affinity to human EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM190268(US9180116, 2C)
Affinity DataKi:  0.378nMAssay Description:Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50319840((S)-4-(1-(1-(3-chloro-5-(trifluoromethoxy)benzyl)-...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50372075(CHEMBL256183)
Affinity DataKi:  0.380nMAssay Description:Binding affinity to human EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50372063(CHEMBL271095)
Affinity DataKi:  0.380nMAssay Description:Binding affinity to human EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50335992(CHEMBL1669006 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...)
Affinity DataKi:  0.390nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50101858(4-(2-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxy-4-(3...)
Affinity DataKi:  0.396nMAssay Description:Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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