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Found 1093 for UniProtKB: P35499
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141067(3-[4-(2,4-Difluoro-phenoxy)-phenyl]-pyrazole-1-car...)
Affinity DataKi:  25nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141062(3-[4-(4-Fluoro-phenoxy)-phenyl]-pyrazole-1-carboxy...)
Affinity DataKi:  31nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141070(3-[4-(4-Nitro-phenoxy)-phenyl]-pyrazole-1-carboxyl...)
Affinity DataKi:  31nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141072(3-(4-Phenoxy-phenyl)-pyrazole-1-carboxylic acid am...)
Affinity DataKi:  35nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141065(3-[4-(4-Fluoro-phenoxy)-phenyl]-pyrazole-1-carboxy...)
Affinity DataKi:  150nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141073((E)-2-(4-(4-fluorophenoxy)benzylidene)hydrazinecar...)
Affinity DataKi:  180nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141066(3-[4-(4-Fluoro-phenoxy)-phenyl]-1H-pyrazole | CHEM...)
Affinity DataKi:  200nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141064(3-(4-Phenoxy-phenyl)-1H-pyrazole | CHEMBL41864)
Affinity DataKi:  240nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141071(3-[4-(4-Fluoro-phenoxy)-phenyl]-pyrazole-1-carboxy...)
Affinity DataKi:  340nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141069(3-[4-(4-Fluoro-phenoxy)-phenyl]-1-methyl-1H-pyrazo...)
Affinity DataKi:  690nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50031299(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)
Affinity DataKi:  1.70E+4nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50003655(Phenytoin)
Affinity DataKi:  2.40E+4nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50003659(5H-dibenzo[b,f]azepine-5-carboxamide | CARBAMAZEPI...)
Affinity DataKi:  5.20E+4nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50078831(3-Phenyl-1H-pyrazole | CHEMBL38876)
Affinity DataKi:  6.10E+4nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141063(3-(4-Methoxy-phenyl)-1H-pyrazole | CHEMBL39210)
Affinity DataKi:  8.10E+4nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50118519(CHEMBL3617050)
Affinity DataIC50:  0.0620nMAssay Description:Inhibition of NaV1.4 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71381(US9546164, 440 | US9694002, 440)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71340(US9546164, 411 | US9694002, 411)
Affinity DataIC50:  0.800nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71351(US9546164, 422 | US9694002, 422)
Affinity DataIC50:  1.30nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71341(US9546164, 412 | US9694002, 412)
Affinity DataIC50:  1.5nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71063(US9546164, 208 | US9694002, 208)
Affinity DataIC50:  1.60nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71193(US9546164, 300 | US9694002, 300)
Affinity DataIC50:  1.60nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71101(US9546164, 236 | US9694002, 236)
Affinity DataIC50:  1.60nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71055(US9546164, 202 | US9694002, 202)
Affinity DataIC50:  1.60nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM70878(US9546164, 52 | US9694002, 52)
Affinity DataIC50: <1.60nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71067(US9546164, 211 | US9694002, 211)
Affinity DataIC50:  1.70nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM70836(US9694002, 23)
Affinity DataIC50:  1.70nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM70848(US9694002, 29)
Affinity DataIC50:  1.70nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71064(US9546164, 209 | US9694002, 209)
Affinity DataIC50:  1.70nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71062(US9546164, 207 | US9694002, 207)
Affinity DataIC50:  1.70nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71061(US9546164, 206 | US9694002, 206)
Affinity DataIC50:  1.80nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM70855(US9694002, 34)
Affinity DataIC50:  1.90nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71192(US9546164, 299 | US9694002, 299)
Affinity DataIC50:  1.90nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM70982(US9546164, 136 | US9694002, 136)
Affinity DataIC50:  1.90nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71224(US9546164, 323 | US9694002, 323)
Affinity DataIC50:  1.90nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71222(US9546164, 322 | US9694002, 322)
Affinity DataIC50:  1.90nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71065(US9546164, 210 | US9694002, 210)
Affinity DataIC50:  1.90nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM70876(US9546164, 50 | US9694002, 50 | US9694002, 51)
Affinity DataIC50:  1.90nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50595862(CHEMBL5189924)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50595859(CHEMBL5192731)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71285(US9546164, 361 | US9694002, 361)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71271(US9546164, 352 | US9694002, 352)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71006(US9546164, 155 | US9694002, 155)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71352(US9546164, 423 | US9694002, 423)
Affinity DataIC50:  2.10nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM71328(US9546164, 400 | US9694002, 400)
Affinity DataIC50:  2.10nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM70985(US9546164, 137 | US9694002, 137)
Affinity DataIC50:  2.10nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM70866(US9694002, 42)
Affinity DataIC50:  2.10nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM70946(US9546164, 107 | US9694002, 107)
Affinity DataIC50:  2.10nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM70876(US9546164, 50 | US9694002, 50 | US9694002, 51)
Affinity DataIC50:  2.10nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent
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