Compile Data Set for Download or QSAR
Report error Found 5276 of affinity data for UniProtKB/TrEMBL: P36897
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50454871(CHEMBL4209835)
Affinity DataKi:  0.140nMAssay Description:Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM412734(US10399987, Example 1 | N-(3-fluoropyridin-4-yl)-2...)
Affinity DataKi:  0.140nMAssay Description:Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM412755(US10399987, Example 20 | N-(4-((2-(6-(trifluoromet...)
Affinity DataKi:  0.150nMAssay Description:Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM747282(29 N,N-Dimethyl-2-(4-(2-(6- methylpyridin-2-yl)-6,...)
Affinity DataIC50: 0.180nMAssay Description:The principle of the activity assay was that TGFβR1 phosphorylates the substrate TGFβR1tide, consuming ATP in the process. This experiment employed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/26/2025
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM747282(29 N,N-Dimethyl-2-(4-(2-(6- methylpyridin-2-yl)-6,...)
Affinity DataIC50: 0.180nMAssay Description:The principle of the activity assay was that TGFβR1 phosphorylates the substrate TGFβR1tide, consuming ATP in the process. This experiment employed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM406730(N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2...)
Affinity DataIC50: 0.190nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM406730(N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2...)
Affinity DataIC50: 0.190nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM412745(US10399987, Example 10 | N-(3-fluoropyridin-4-yl)-...)
Affinity DataKi:  0.220nMAssay Description:Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM406951(1-({[2-(5-fluoropyridin-2-yl)-4-[(3-fluoropyridin-...)
Affinity DataIC50: 0.25nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1 [4-503,T204D](Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412768(US10399987, Example 33 | N-(3-fluoropyridin-4-yl)-...)
Affinity DataIC50: 0.25nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1 [4-503,T204D](Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412735(US10399987, Example 2 | 2-(6-(difluoromethyl)pyrid...)
Affinity DataIC50: 0.25nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM406793(N-{5-[(4,4-difluoropiperidin-1-yl)methyl]-2-(6-met...)
Affinity DataIC50: 0.25nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM407012((3-{[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-...)
Affinity DataIC50: 0.25nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM407009(N-(4-{[5-(morpholin-4-ylmethyl)-2-(pyridin-2-yl)py...)
Affinity DataIC50: 0.25nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1 [4-503,T204D](Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412743(US10399987, Example 8 | N-(3-fluoropyridin-4-yl)-2...)
Affinity DataIC50: 0.260nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  0.266nMAssay Description:Binding affinity to human TGFBR1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM406957(3-fluoro-N-(5-{[(1-methylcyclobutyl)amino]methyl}-...)
Affinity DataIC50: 0.270nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1 [T204D](Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM283066(6-(1-(1-cyanocyclopropyl)-4-(4-fluorophenyl)-1H- i...)
Affinity DataIC50: 0.300nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM283066(6-(1-(1-cyanocyclopropyl)-4-(4-fluorophenyl)-1H- i...)
Affinity DataIC50: 0.300nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM407043(2-[(3R)-3-hydroxypyrrolidin-1-yl]-N-[4-({2-[6-(tri...)
Affinity DataIC50: 0.300nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM283066(6-(1-(1-cyanocyclopropyl)-4-(4-fluorophenyl)-1H- i...)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50579200(CHEMBL4852453)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50255960(4-(6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)thiazo...)
Affinity DataKi:  0.330nMAssay Description:Binding affinity to human TGFBR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50579201(CHEMBL4858177)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50579196(CHEMBL4877947)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM407051(N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[...)
Affinity DataIC50: 0.370nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1 [4-503,T204D](Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412766(US10399987, Example 31 | N-(4-((2-(6-(difluorometh...)
Affinity DataIC50: 0.370nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM406787(3-chloro-N-[2-(6-fluoropyridin-2-yl)pyrrolo[2,1-f]...)
Affinity DataIC50: 0.390nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM406741(N-[4-({5-[(4,4-difluoropiperidin-1-yl)methyl]-2-(p...)
Affinity DataIC50: 0.400nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM282914(6-(4-(3-chloro-4-fluorophenyl)-1-ethyl-1H-imidazol...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
US Patent

TargetTGF-beta receptor type-1 [T204D](Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282914(6-(4-(3-chloro-4-fluorophenyl)-1-ethyl-1H-imidazol...)
Affinity DataIC50: 0.400nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM282914(6-(4-(3-chloro-4-fluorophenyl)-1-ethyl-1H-imidazol...)
Affinity DataIC50: 0.400nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM282817(6-(4-(4-fluorophenyl)-1-isopropyl-1H-imidazol-5- y...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
US Patent

TargetTGF-beta receptor type-1 [T204D](Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM396701(US9981944, Example 46 | 6-(6'-chloro-[2,2'-bipyrid...)
Affinity DataIC50: 0.400nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1 [T204D](Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282817(6-(4-(4-fluorophenyl)-1-isopropyl-1H-imidazol-5- y...)
Affinity DataIC50: 0.400nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM407010(N-(5-{[(2H-1,3-benzodioxol-5-ylmethyl)amino]methyl...)
Affinity DataIC50: 0.400nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM282817(6-(4-(4-fluorophenyl)-1-isopropyl-1H-imidazol-5- y...)
Affinity DataIC50: 0.400nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent

TargetTGF-beta receptor type-1 [4-503,T204D](Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412738(US10399987, Example 4 | 2-(pyrrolidin-1-yl)-N-(4-(...)
Affinity DataIC50: 0.420nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM406783(N-{2-[6-(difluoromethyl)-5-fluoropyridin-2-yl]pyrr...)
Affinity DataIC50: 0.460nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM406991(3-[4-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-...)
Affinity DataIC50: 0.470nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM406968((3S)-1-({4-[(3-fluoropyridin-4-yl)amino]-2-(6-meth...)
Affinity DataIC50: 0.490nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1 [T204D](Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282968(6-(1-cyclobutyl-4-(4-fluorophenyl)-1H-imidazol-5- ...)
Affinity DataIC50: 0.5nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM282966(6-(4-(4-fluorophenyl)-1-isopropyl-1H-imidazol-5- y...)
Affinity DataIC50: 0.5nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM282968(6-(1-cyclobutyl-4-(4-fluorophenyl)-1H-imidazol-5- ...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM282968(6-(1-cyclobutyl-4-(4-fluorophenyl)-1H-imidazol-5- ...)
Affinity DataIC50: 0.5nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent

TargetTGF-beta receptor type-1 [T204D](Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282899(6-(4-(3-chloro-4-fluorophenyl)-1-(3-fluorocyclobut...)
Affinity DataIC50: 0.5nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM282899(6-(4-(3-chloro-4-fluorophenyl)-1-(3-fluorocyclobut...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
US Patent

TargetTGF-beta receptor type-1 [T204D](Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282966(6-(4-(4-fluorophenyl)-1-isopropyl-1H-imidazol-5- y...)
Affinity DataIC50: 0.5nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM282899(6-(4-(3-chloro-4-fluorophenyl)-1-(3-fluorocyclobut...)
Affinity DataIC50: 0.5nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM282966(6-(4-(4-fluorophenyl)-1-isopropyl-1H-imidazol-5- y...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
US Patent

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