Compile Data Set for Download or QSAR
Report error Found 486 for UniProtKB: P42224
LigandChemical structure of BindingDB Monomer ID 50507816BDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataIC50: 2nMAssay Description:Inhibition of IFNalpha-induced STAT1 phosphorylation in human PBMC cells incubated for 4 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50557878BDBM50557878(CHEMBL4776801)
Affinity DataKd: >10nMAssay Description:Binding affinity to human recombinant STAT1 assessed as dissociation constant incubated for 15 mins by biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50507816BDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataIC50: 34nMAssay Description:Inhibition of IFN-alpha induced STAT1 phosphorylation in human whole blood preincubated with compound for 30 mins followed by IFN-alpha induction and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50557482BDBM50557482(CHEMBL4747591)
Affinity DataIC50: 50nMAssay Description:Inhibition of IFNalpha-induced STAT1 phosphorylation in human PBMC cells incubated for 4 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50657475BDBM50657475(CHEMBL6146315)
Affinity DataIC50: 56nMAssay Description:Inhibition of IFNalpha-induced STAT1 phosphorylation in human PBMC cells incubated for 4 daysMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50631296BDBM50631296(CHEMBL5397297)
Affinity DataEC50:  71nMAssay Description:Inhibition of STAT1 phosphorylation in human SK-MES-1 cells pretreated for 30 mins followed by IL-6 stimulation by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50557482BDBM50557482(CHEMBL4747591)
Affinity DataIC50: 74nMAssay Description:Inhibition of IL-6 induced STAT1 phosphorylation in human whole blood preincubated with compound for 30 mins followed by IL-6 induction and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50557482BDBM50557482(CHEMBL4747591)
Affinity DataIC50: 85nMAssay Description:Inhibition of IFN-alpha induced STAT1 phosphorylation in human whole blood preincubated with compound for 30 mins followed by IFN-alpha induction and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetJAK1/STAT1(Human)
Ocean University of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50408050BDBM50408050(CHEMBL5282944)
Affinity DataIC50: 191nMAssay Description:Inhibition of JAK/STAT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50557482BDBM50557482(CHEMBL4747591)
Affinity DataIC50: 200nMAssay Description:Inhibition of GM-CSF induced STAT1 phosphorylation in human PBMC cells incubated for 4 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50657475BDBM50657475(CHEMBL6146315)
Affinity DataIC50: 247nMAssay Description:Inhibition of IFN-alpha induced STAT1 phosphorylation in human whole blood preincubated with compound for 30 mins followed by IFN-alpha induction and...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50657725BDBM50657725(CHEMBL6144023)
Affinity DataIC50: 270nMAssay Description:Binding affinity to STAT1 (unknown origin) by FP assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50569071BDBM50569071(CHEMBL4846365)
Affinity DataIC50: 320nMAssay Description:Inhibition of IFN-gamma-induced STAT1 transcriptional activity in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50569070BDBM50569070(CHEMBL4864495)
Affinity DataIC50: 350nMAssay Description:Inhibition of IFN-gamma-induced STAT1 transcriptional activity in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50657475BDBM50657475(CHEMBL6146315)
Affinity DataIC50: 480nMAssay Description:Inhibition of IL-6 induced STAT1 phosphorylation in human whole blood preincubated with compound for 30 mins followed by IL-6 induction and measured ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 103727BDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 629nMAssay Description:Inhibition of IL-6 induced STAT1 phosphorylation in human whole blood preincubated with compound for 30 mins followed by IL-6 induction and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50507816BDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataIC50: 660nMAssay Description:Inhibition of IL-6 induced STAT1 phosphorylation in human whole blood preincubated with compound for 30 mins followed by IL-6 induction and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50070942BDBM50070942((-)-Epigallocatechin-3-o-gallate | (-)-Epigallocat...)
Affinity DataKd:  700nMAssay Description:Binding affinity to STAT1 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50507816BDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataIC50: 851nMAssay Description:Inhibition of GM-CSF induced STAT1 phosphorylation in human PBMC cells incubated for 4 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50569085BDBM50569085(CHEMBL4846078)
Affinity DataIC50: 880nMAssay Description:Inhibition of IFN-gamma-induced STAT1 transcriptional activity in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514302BDBM50514302(CHEMBL4452527)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT1 (132 to 713 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514302BDBM50514302(CHEMBL4452527)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to His-tagged human STAT1 (132 to 713 residues) expressed in Escherichia coli Rosette (DE3) assessed as dissociation constant using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 103727BDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of IFN-alpha induced STAT1 phosphorylation in human whole blood preincubated with compound for 30 mins followed by IFN-alpha induction and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50514302BDBM50514302(CHEMBL4452527)
Affinity DataIC50: 1.30E+3nMAssay Description:Binding affinity to STAT1 (unknown origin) by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50207367BDBM50207367(CHEMBL3952820)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Stat1 (unknown origin) expressed in LPS/INF-gamma-stimulated human MONO-MAC-6 cells assessed as reduction in GAS dependent transcriptio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50207369BDBM50207369(CHEMBL3968323)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Stat1 (unknown origin) expressed in LPS/INF-gamma-stimulated human MONO-MAC-6 cells assessed as reduction in GAS dependent transcriptio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50382460BDBM50382460(CHEMBL2023985 | US10196373, Compound 27NA)
Affinity DataKi:  3.20E+3nMAssay Description:Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 43505BDBM43505(ethyl 4-[4-(4-oxidanylidene-2-sulfanylidene-1H-qui...)
Affinity DataIC50: 3.47E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 43529BDBM43529(2-(4-methylphenyl)-5-pyridin-4-yl-4H-benzo[i][1,3,...)
Affinity DataIC50: 3.52E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 50657475BDBM50657475(CHEMBL6146315)
Affinity DataIC50: 3.85E+3nMAssay Description:Inhibition of GM-CSF induced STAT1 phosphorylation in human PBMC cells incubated for 4 daysMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 43519BDBM43519(3-[[4-(2-fluorophenyl)-1,3-thiazol-2-yl]methyl]-2-...)
Affinity DataIC50: 4.24E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 43527BDBM43527(cid_5686694 | MLS000394219 | 2-[(7-hydroxy-2-oxo-1...)
Affinity DataIC50: 4.36E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 43517BDBM43517(SMR000218837 | N'-[(1,3-diethyl-4,6-dioxo-2-sulfan...)
Affinity DataIC50: 4.42E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 50448069BDBM50448069(CHEMBL3120621)
Affinity DataKd:  4.67E+3nMAssay Description:Binding affinity to STAT1 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 43512BDBM43512(MLS000544969 | 3-(3,4-dimethylphenyl)-4-oxo-3,4-di...)
Affinity DataIC50: 5.20E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 50440967BDBM50440967(CHEMBL2431993 | US10196373, Compound BP2-061)
Affinity DataIC50: 5.80E+3nMAssay Description:Binding affinity to Stat1 (unknown origin) using 5-FAM-GpYLPQTV-NH2 as probe assessed as phosphopetide complex formation after 30 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 196138BDBM196138(US9211296, Table 7, Compd: 9)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of IFNgamma-induced STAT1 phosphorylation in human Cal33 cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 43507BDBM43507(SMR000082759 | 4-[4-(2-methoxyphenyl)-6-(trifluoro...)
Affinity DataIC50: 6.19E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 43511BDBM43511(diethyl 2-[[(5-methyl-2-phenylpyrazol-3-yl)amino]m...)
Affinity DataIC50: 6.37E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 36973BDBM36973(SMR000064688 | MLS000056603 | 1-[[5-[5-(4-methylph...)
Affinity DataIC50: 6.70E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 50207368BDBM50207368(CHEMBL3904582)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Stat1 (unknown origin) expressed in LPS/INF-gamma-stimulated human MONO-MAC-6 cells assessed as reduction in GAS dependent transcriptio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 43521BDBM43521(MLS000394345 | N-(4-fluorophenyl)-2-[4-(4-methylph...)
Affinity DataIC50: 7.87E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 39665BDBM39665((2E)-2-[(3-methylthiophen-2-yl)methylidene]-3,4-di...)
Affinity DataIC50: 7.89E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 50240455BDBM50240455(CHEMBL1253351)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of 5-carboxyfluorescein-GpYDKPHVL-OH binding to STAT1 (unknown origin) pre-incubated for 1 hr before fluorescent-labelled peptide addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 43510BDBM43510(5-(phenylmethyl)-3-pyrrolidin-1-ylcarbonyl-benzo[b...)
Affinity DataIC50: 8.43E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 50353444BDBM50353444(CHEMBL1829870 | US10196373, Compound 45C)
Affinity DataKi:  8.80E+3nMAssay Description:Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50000029BDBM50000029(suramin | SURAMIN HEXASODIUM | CHEMBL265502 | 4-Me...)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of 5-carboxyfluorescein-GpYDKPHVL-OH binding to STAT1 (unknown origin) pre-incubated for 1 hr before fluorescent-labelled peptide addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 43508BDBM43508(cid_2802825 | N-[1-(4-methyl-6-oxidanylidene-pyrim...)
Affinity DataIC50: 9.25E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 43526BDBM43526(2-[[2-(2,4-dihydroxyphenyl)-2-oxoethyl]thio]-1H-qu...)
Affinity DataIC50: 9.39E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
LigandChemical structure of BindingDB Monomer ID 50382459BDBM50382459(CHEMBL2023986 | US10196373, Compound 27NH)
Affinity DataKi:  9.50E+3nMAssay Description:Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
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