Compile Data Set for Download or QSAR
Report error Found 412 of affinity data for UniProtKB/TrEMBL: P42226
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304425BDBM50304425(2-(4-morpholinophenylamino)-4-(2,3,6-trifluorobenz...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50243934BDBM50243934(CHEMBL487451 | CHEMBL488307 | AS-1617612 | 2-[(4-M...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50244291BDBM50244291(4-[(2-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50243884BDBM50243884(4-[(2,5-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50243933BDBM50243933(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2,3,5-triflu...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50244292BDBM50244292(4-[(3-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304429BDBM50304429(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50243882BDBM50243882(4-[(2,3-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50243885BDBM50243885(4-[(2,6-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304433BDBM50304433(7-(3,5-Difluorobenzyl)-N-[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304428BDBM50304428(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50243932BDBM50243932(4-[(3,5-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304432BDBM50304432(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658926BDBM50658926(CHEMBL6169593)
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658924BDBM50658924(CHEMBL6148327)
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658882BDBM50658882(CHEMBL6169609)
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50244256BDBM50244256(4-Benzylamino-2-{[4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50244258BDBM50244258(4-(benzylamino)-2-(4-morpholinophenylamino)pyrimid...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50244258BDBM50244258(4-(benzylamino)-2-(4-morpholinophenylamino)pyrimid...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50244257BDBM50244257(4-Benzylamino-2-[(4-piperazin-1-ylphenyl)amino]-py...)
Affinity DataIC50: 7nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50244331BDBM50244331(4-[(2-Chlorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50244329BDBM50244329(4-[(2-Methoxybenzyl)amino]-2-[(4-morpholin-4-ylphe...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784518BDBM784518(2-Amino-5-[2-[[4-[4- (dimethylcarbamoyl)phenyl]-1-...)
Affinity DataKd:  9.05nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658925BDBM50658925(CHEMBL6146875)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50557878BDBM50557878(CHEMBL4776801)
Affinity DataKd: >10nMAssay Description:Binding affinity to human recombinant STAT6 assessed as dissociation constant incubated for 15 mins by biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658923BDBM50658923(CHEMBL6132917)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50244294BDBM50244294(4-[(2-Methylbenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50: 11nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784494BDBM784494(Ethyl 6-amino-3-[2-[[4-[4- (dimethylcarbamoyl)phen...)
Affinity DataKd:  11nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784488BDBM784488(4-[1-[[4-(6-Amino-3-pyridyl)-1- methyl-pyrrolo[2,3...)
Affinity DataKd:  11.4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 782768BDBM782768(US20250325677, Example 3p1)
Affinity DataKd:  11.4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304434BDBM50304434(7-(3,5-Difluorobenzyl)-N-(4-piperazin-1-ylphenyl)-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784465BDBM784465(2-(2-Amino-5-(2-((4-(4- (dimethylcarbamoyl)phenyl)...)
Affinity DataKd:  12.8nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784429BDBM784429(US20250340551, Example 1af12)
Affinity DataKd:  12.9nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784526BDBM784526(4-[1-[[4-(6-Aminopyridazin-3-yl)-1- methyl-pyrrolo...)
Affinity DataKd:  13.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784464BDBM784464(US20250340551, Example 1af8)
Affinity DataKd:  14.6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784450BDBM784450(US20250340551, Example 1af33)
Affinity DataKd:  15.4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784433BDBM784433(US20250340551, Example 1af16)
Affinity DataKd:  15.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784453BDBM784453(US20250340551, Example 1af36)
Affinity DataKd:  15.7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784496BDBM784496(N,N-Dimethyl-4-[1-[1-methyl-4-[6- (methylamino)-3-...)
Affinity DataKd:  16nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50244223BDBM50244223(4-Benzylamino-2-{[4-(4-hydroxypiperidin-1-yl)pheny...)
Affinity DataIC50: 16nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784601BDBM784601(N,N,3-Trimethyl-4-[1-[[1-methyl-4-[5- (methylamino...)
Affinity DataKd:  16nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784521BDBM784521(2-[[5-[2-[[4-[4- (Dimethylcarbamoyl)phenyl]-1- pip...)
Affinity DataKd:  16.3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784520BDBM784520(4-[1-[[4-[6-(2-Hydroxyethylamino)-3- pyridyl]-1-me...)
Affinity DataKd:  16.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784485BDBM784485(Methyl 2-[[5-[2-[[4-[4- (dimethylcarbamoyl)phenyl]...)
Affinity DataKd:  16.8nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50244259BDBM50244259(4-Benzylamino-2-{[4-(1-methylpiperidin-4-yl)phenyl...)
Affinity DataIC50: 17nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784570BDBM784570(N,N-Dimethyl-4-[(2R,4R)-1-[[4-(5- amino-2-pyridyl)...)
Affinity DataKd:  18.1nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784573BDBM784573(N,N-Dimethyl-4-[(2R,4R)-1-[[4-(6- amino-2-cyano-3-...)
Affinity DataKd:  18.4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784431BDBM784431(US20250340551, Example 1af14)
Affinity DataKd:  18.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784451BDBM784451(US20250340551, Example 1af34)
Affinity DataKd:  18.6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

TargetSignal transducer and activator of transcription 6(Human)
Astellas Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 784524BDBM784524(4-(1-((4-(5-Aminopyridin-2-yl)-1- methyl-1H-pyrrol...)
Affinity DataKd:  18.8nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent

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