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TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  3.00E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  190nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM5931(cid_3025986 | CHEMBL296468 | N-(5-{[(5-tert-butyl-...)
Affinity DataKd:  76nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31099(CHEMBL45741 | Flavopiridol | cid_24867231 | 2-(2-c...)
Affinity DataKd:  6.40nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  470nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  100nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM180837(US9133171, 42)
Affinity DatapH: 8.0 T: 2°CAssay Description:Recombinant full-length His-tagged human CDK9 and CycT1, expressed in insect cells and purified by Ni-NTA affinity chromatography, were purchase from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2016
Entry Details
US Patent

TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737469(US20250136619, Compound I-42)
Affinity DataKd:  275nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737490(US20250136619, Compound I-55)
Affinity DataKd:  275nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737491(US20250136619, Compound I-56)
Affinity DataKd:  275nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737492(US20250136619, Compound I-83)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737493(US20250136619, Compound I-86)
Affinity DataKd:  1.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737494(US20250136619, Compound I-87)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737477(US20250136619, Compound I-64)
Affinity DataKd:  1.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737478(US20250136619, Compound I-82)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737479(US20250136619, Compound I-67)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737480(US20250136619, Compound I-68)
Affinity DataKd:  1.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737481(US20250136619, Compound I-77)
Affinity DataKd:  275nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737482(US20250136619, Compound I-80)
Affinity DataKd:  275nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737483(US20250136619, Compound I-70)
Affinity DataKd:  275nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737484(US20250136619, Compound I-79)
Affinity DataKd:  275nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737485(US20250136619, Compound I-69)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737486(US20250136619, Compound I-81)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737495(US20250136619, Compound I-96)
Affinity DataKd:  275nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737496(US20250136619, Compound I-97)
Affinity DataKd:  275nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737497(US20250136619, Compound I-98)
Affinity DataKd:  275nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737498(US20250136619, Compound I-92)
Affinity DataKd:  1.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM737499(US20250136619, Compound I-93)
Affinity DataKd:  1.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50466210(CHEMBL4281048)
Affinity DataEC50: <100nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as decrease in RNA polymerase 2 phosphorylation at Ser 2 residues in CTD domain after 2 hrs by immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50466210(CHEMBL4281048)
Affinity DataEC50: <100nMAssay Description:Inhibition of CDK9 in human HL60 cells assessed as decrease in RNA polymerase 2 phosphorylation at Ser 2 residues in CTD domain after 2 hrs by immuno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50466210(CHEMBL4281048)
Affinity DataEC50: <100nMAssay Description:Inhibition of CDK9 in human MEC1 cells assessed as decrease in RNA polymerase 2 phosphorylation at Ser 2 residues in CTD domain after 2 hrs by immuno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  162nMAssay Description:Binding affinity to recombinant human full length N-terminal GST-tagged CDK9 co-expressed with full length N-terminal His-tagged CyclinT1 expressed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  116nMAssay Description:Binding affinity to recombinant human full length N-terminal GST-tagged CDK9 co-expressed with full length N-terminal His-tagged CyclinT1 expressed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full length CDK9 (M1 to F372 residues) expressed in bacterial expression system measured after 1 hr by kinomescan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50538150(CHEMBL4647703)
Affinity DataKd:  30nMAssay Description:Binding affinity to recombinant full-length GFP-fused CDK9/His-tagged cyclin T1 (unknown origin) expressed in HEK293T cells measured after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50540079(CHEMBL4632717)
Affinity DataKd:  5.40nMAssay Description:Binding affinity to CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataKd:  711nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as dissociation rate constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM454542(US10717746, Example 25 | US10717746, Example 84)
Affinity DataKd:  569nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as dissociation rate constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM454519(US10717746, Example 2)
Affinity DataKd:  3.64E+3nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as dissociation rate constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataKd:  0.0894nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as equilibrium dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM454542(US10717746, Example 25 | US10717746, Example 84)
Affinity DataKd:  0.123nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as equilibrium dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM454519(US10717746, Example 2)
Affinity DataKd:  0.295nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as equilibrium dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM454544(US10717746, Example 27)
Affinity DataEC50:  38nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM454567(US10717746, Example 48)
Affinity DataEC50:  15nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50549515(CHEMBL4759074)
Affinity DataEC50:  68nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50549515(CHEMBL4759074)
Affinity DataEC50:  4.80E+3nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM454562(US10717746, Example 43)
Affinity DataEC50:  420nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM454539(US10717746, Example 22)
Affinity DataEC50:  54nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM454559(US10717746, Example 40 | US10717746, Example 41)
Affinity DataEC50:  92nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM454559(US10717746, Example 40 | US10717746, Example 41)
Affinity DataEC50:  77nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
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