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Report error Found 2826 of affinity data for UniProtKB/TrEMBL: P53350
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50343559BDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 0.00200nMAssay Description:Inhibition of PLK1 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25121BDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50: 0.0830nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355500BDBM50355500(CHEMBL1908394 | US9695172, GSK461364)
Affinity DataKd:  0.0940nMAssay Description:Binding constant for PLK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660592BDBM50660592(CHEMBL6145835)
Affinity DataIC50: 0.120nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660622BDBM50660622(CHEMBL6145038)
Affinity DataIC50: 0.130nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660615BDBM50660615(CHEMBL6159528)
Affinity DataIC50: 0.150nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621090BDBM50621090(CHEMBL5417495)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626599BDBM50626599(CHEMBL5423881)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25121BDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd:  0.190nMAssay Description:Binding constant for PLK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626575BDBM50626575(CHEMBL5419732)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660627BDBM50660627(CHEMBL6168202)
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526296BDBM50526296(CHEMBL4449858)
Affinity DataKd:  0.190nMAssay Description:Binding affinity to PLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25121BDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd:  0.190nMAssay Description:Binding affinity to PLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621081BDBM50621081(CHEMBL5416208)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660617BDBM50660617(CHEMBL6152272)
Affinity DataIC50: 0.210nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25121BDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKi:  0.220nMAssay Description:Binding affinity to PLK1 (unknown origin) expressed in HEK293 cells after 1 hr by proprietary competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626583BDBM50626583(CHEMBL5433401)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626579BDBM50626579(CHEMBL5438707)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626606BDBM50626606(CHEMBL5415945)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660620BDBM50660620(CHEMBL6173341)
Affinity DataIC50: 0.270nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660591BDBM50660591(CHEMBL6168713)
Affinity DataIC50: 0.270nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660614BDBM50660614(CHEMBL6165777)
Affinity DataIC50: 0.280nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621072BDBM50621072(CHEMBL5426964)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626573BDBM50626573(CHEMBL5421113)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621077BDBM50621077(CHEMBL5419367)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621046BDBM50621046(CHEMBL5429440)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621080BDBM50621080(CHEMBL5422122)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660595BDBM50660595(CHEMBL6149970)
Affinity DataIC50: 0.310nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626602BDBM50626602(CHEMBL5435085)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660599BDBM50660599(CHEMBL6172114)
Affinity DataIC50: 0.320nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626587BDBM50626587(CHEMBL5429110)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660612BDBM50660612(CHEMBL6134427)
Affinity DataIC50: 0.330nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626587BDBM50626587(CHEMBL5429110)
Affinity DataIC50: 0.330nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660607BDBM50660607(CHEMBL6176603)
Affinity DataIC50: 0.340nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660613BDBM50660613(CHEMBL6170664)
Affinity DataIC50: 0.340nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660611BDBM50660611(CHEMBL6133790)
Affinity DataIC50: 0.340nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626593BDBM50626593(CHEMBL5438696)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660621BDBM50660621(CHEMBL6168781)
Affinity DataIC50: 0.350nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660619BDBM50660619(CHEMBL6166604)
Affinity DataIC50: 0.350nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660596BDBM50660596(CHEMBL6163361)
Affinity DataIC50: 0.350nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626603BDBM50626603(CHEMBL5398211)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660582BDBM50660582(CHEMBL6142292)
Affinity DataIC50: 0.380nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660618BDBM50660618(CHEMBL6167292)
Affinity DataIC50: 0.390nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626577BDBM50626577(CHEMBL5396078)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621071BDBM50621071(CHEMBL5427957)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626576BDBM50626576(CHEMBL5437785)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50232582BDBM50232582(CHEMBL4067710)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human FLAG-tagged PLK1 expressed in baculovirus infected sf21 cells using Biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660597BDBM50660597(CHEMBL6175691)
Affinity DataIC50: 0.410nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660616BDBM50660616(CHEMBL6168752)
Affinity DataIC50: 0.410nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences Srl

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621086BDBM50621086(CHEMBL5403473)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of PLK1 (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by ADP-Glo kinase assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
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