Compile Data Set for Download or QSAR
Report error Found 1782 of affinity data for UniProtKB/TrEMBL: Q13255
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50301822(CHEMBL568443 | CHEMBL1645349 | 5-(1-(2-fluoropyrid...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to mGluR1 by PET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50301822(CHEMBL568443 | CHEMBL1645349 | 5-(1-(2-fluoropyrid...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50364722(CHEMBL1951661)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50224402(8-(4-chlorophenyl)-1h-pyrrolo[2'',3'':4',5']pyrido...)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50: 0.550nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50: 0.550nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50163613((2,3-Dihydro-1H-cyclopenta[b]quinolin-7-yl)-(4-met...)
Affinity DataIC50: 0.560nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50224390(8-(4-methylphenyl)-1h-pyrrolo[2'',3'':4',5']pyrido...)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50364700(CHEMBL1951872)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50333368([11C]-cis-(3-ethyl-2-methylquinolin-6-yl)(4-methox...)
Affinity DataKi:  0.870nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50333368([11C]-cis-(3-ethyl-2-methylquinolin-6-yl)(4-methox...)
Affinity DataKi:  0.870nMAssay Description:Binding affinity to mGluR1 by PET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50345947(3-(4-Chloro-phenyl)-9-prop-2-ynylamino-3H-pyrido[3...)
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50163596((2-Amino-3-ethyl-quinolin-6-yl)-(4-methoxy-cyclohe...)
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50401714(CHEMBL2205923)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50401688(CHEMBL2205921)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50401715(CHEMBL2205922)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50177100(9-dimethylamino-3-cycoheptyl-3H-5-thia-1,3,6-triaz...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50345937(9-(Allyl-methyl-amino)-3-(4-chloro-phenyl)-3H-pyri...)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50: 1.21nMAssay Description:Antagonist activity at human mGlu1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50224406(9-(4-chlorophenyl)-2,3-dihydro-3(R)-methyl-1H-pyri...)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50345948(9-Prop-2-ynylamino-3-p-tolyl-3H-pyrido[3',2':4,5]t...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50345950(3-(4-Bromo-phenyl)-9-prop-2-ynylamino-3H-pyrido[3'...)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50301542(4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50345954(3-(4-Bromo-phenyl)-9-(methyl-prop-2-ynyl-amino)-3H...)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50273942(CHEMBL502882 | CHEMBL1645350 | 4-[1-(2-Fuluoropyri...)
Affinity DataKi:  2nMAssay Description:Binding affinity to mGluR1 by PET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50163617((2,3-Dihydro-thieno[2,3-b]quinolin-6-yl)-(4-methox...)
Affinity DataIC50: 2nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50364699(CHEMBL1951690)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50401689(CHEMBL2205920)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50364709(CHEMBL1951881)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50345931(9-Allylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50345949(3-(4-Methoxy-phenyl)-9-prop-2-ynylamino-3H-pyrido[...)
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50316005(7,9-Diamino-3-p-tolyl-3H-thieno[2,3-d:4,5-d']dipyr...)
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50224396(9-(4-chlorophenyl)-2,3-dihydro-3(S)-methyl-1H-pyri...)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50224395(2,3-dihydro-9-(4-methylphenyl)-1H-pyrimido[4'',5''...)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50364710(CHEMBL1951882)
Affinity DataIC50: 2.30nMAssay Description:Antagonist activity at human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50224407(2,3-dihydro-9-(4-methoxyphenyl)-3(R)-methyl-1H-pyr...)
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50301541(N-(4-(6-aminopyrimidin-4-yl)thiazol-2-yl)-4-fluoro...)
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50224405(2,3-dihydro-9-(4-methoxyphenyl)-1H-pyrimido[4'',5'...)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50273898(tert-Butyl-4-[1-(2-fuluoropyridine-3-yl)-1H-1,2,3-...)
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50301816(2-cyclopropyl-5-(5-methyl-1-(pyridin-3-yl)-1H-1,2,...)
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50224391(9-(4-chlorophenyl)-2,3-dihydro-1H-pyrimido[4'',5''...)
Affinity DataIC50: 2.90nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50177053(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50401678(CHEMBL2205371)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50278288(2-(2-(4-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50177053(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50163589((4-Methoxy-cyclohexyl)-(2-propyl-quinolin-6-yl)-me...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50401680(CHEMBL2205909)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50364707(CHEMBL1951879)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50177053(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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