Compile Data Set for Download or QSAR
Report error Found 1782 of affinity data for UniProtKB/TrEMBL: Q13255
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu1 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as induction of increa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mGlu1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407827(CHEMBL2115160)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for the half-maximal inhibition of cAMP formation in BHK cells expressing mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407821(CHEMBL2115151)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407829(CHEMBL2115153)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407822(CHEMBL2114112)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407824(CHEMBL2114115)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407831(CHEMBL2115156)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407818(CHEMBL2114109)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407830(CHEMBL2115157)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407825(CHEMBL2114110)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407823(CHEMBL2114116)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407820(CHEMBL2115159)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407826(CHEMBL2114105)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407828(CHEMBL2114106)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50076393((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-phenyl-c...)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500947(CHEMBL3797811)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  246nMAssay Description:Positive allosteric modulation of human mGlu1 receptor expressed in wild type T-Rex 293 cells assessed as increase in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  710nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500948(CHEMBL3800589)
Affinity DataEC50:  1.40E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500950(CHEMBL3799600)
Affinity DataEC50:  1.70E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  141nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate pEC50 at 10 uM (Rvb = 6.007 +/- 0.076 No_unit)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  181nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate EC50 at 10 uM (Rvb = 983.4 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500948(CHEMBL3800589)
Affinity DataEC50:  1.41E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500947(CHEMBL3797811)
Affinity DataEC50: <1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM87276(SMR000204124 | N-1,3-benzothiazol-2-yl-9H-xanthene...)
Affinity DataEC50:  4.79E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  724nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500952(CHEMBL3799150)
Affinity DataEC50: <1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  182nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate pEC50 at 10 uM (Rvb = 6.007 +/- 0.076 No_unit)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM87276(SMR000204124 | N-1,3-benzothiazol-2-yl-9H-xanthene...)
Affinity DataEC50:  4.80E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  245nMAssay Description:Positive allosteric modulation of human mGlu1 receptor expressed in wild type T-Rex 293 cells assessed as increase in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500951(CHEMBL3799685)
Affinity DataEC50:  900nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500952(CHEMBL3799150)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500951(CHEMBL3799685)
Affinity DataEC50:  219nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate pEC50 at 10 uM (Rvb = 6.007 +/- 0.076 No_unit)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500951(CHEMBL3799685)
Affinity DataEC50:  219nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate EC50 at 10 uM (Rvb = 983.4 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500953(CHEMBL3798489)
Affinity DataEC50:  2.69E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500951(CHEMBL3799685)
Affinity DataEC50:  912nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  141nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate EC50 at 10 uM (Rvb = 983.4 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500950(CHEMBL3799600)
Affinity DataEC50:  1.70E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500953(CHEMBL3798489)
Affinity DataEC50:  2.70E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50052256(3-[amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-ca...)
Affinity DataEC50: >3.00E+5nMAssay Description:The compound was tested for effect on second messenger formation in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50052255(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Affinity DataEC50: >3.00E+5nMAssay Description:The compound was tested for effect on second messenger formation in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50053589((S)-3-Hydroxyphenylglycine | 3HPG | CHEMBL442347 |...)
Affinity DataEC50:  6.80E+4nMAssay Description:Effective concentration for half maximal stimulation of PI hydrolysis (mGluR1a)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  6.00E+3nMAssay Description:Effective concentration for half maximal stimulation of PI hydrolysis (mGluR1a)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM17660(2-amino-3-(3,5-dioxo[1,2,4]oxadiazolidin-2-yl)prop...)
Affinity DataEC50:  200nMAssay Description:Effective concentration for half maximal stimulation of PI hydrolysis (mGluR1a)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM66976(SMR001230688 | trans-( )-ACPD monohydrate | cid_16...)
Affinity DataEC50:  2.20E+4nMAssay Description:Effective concentration for half maximal stimulation of PI hydrolysis (mGluR1a)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM66976(SMR001230688 | trans-( )-ACPD monohydrate | cid_16...)
Affinity DataEC50:  9.30E+3nMAssay Description:Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50004863(1S, 3R-ACPD | CHEMBL29726 | 1R,3R-ACPD | 1R,3S-ACP...)
Affinity DataEC50: >3.00E+5nMAssay Description:Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50060136((1R,3S)-1-Amino-cyclopentane-1,3-dicarboxylic acid...)
Affinity DataEC50:  1.27E+5nMAssay Description:Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50060133(CHEMBL107845 | 1S, 3S-ACPD | 1-Amino-cyclopentane-...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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