Compile Data Set for Download or QSAR
Report error Found 9546 for UniProtKB: Q13546
LigandPNGBDBM36371(CID2828334 | 5-(1H-indol-3-ylmethyl)-3-methyl-2-th...)
Affinity DataEC50:  182nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assay using RIP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMed
LigandPNGBDBM36372(CID11288934 | (5R)-5-[(7-chloro-1H-indol-3-yl)meth...)
Affinity DataEC50:  18nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assay using RIP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  2.80E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  210nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  320nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataKd:  260nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  1.80E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  1.20E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  370nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  20nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  93.7nMAssay Description:RIP1 kinase assays were performed using ADP-Glo assay (Promega) according to manufacturer's protocol. Reactions were performed in 50 mM HEPES, pH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

LigandPNGBDBM422046(US10508102, Compound A)
Affinity DataEC50:  256nMAssay Description:RIP1 kinase assays were performed using ADP-Glo assay (Promega) according to manufacturer's protocol. Reactions were performed in 50 mM HEPES, pH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

LigandPNGBDBM647661(US20240025912, Compound 1-1 | (5S)-2-(bicyclo[2.2....)
Affinity DataEC50:  21.6nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647662(US20240025912, Compound 1-61 | (S)-2-(bicyclo[2.1....)
Affinity DataEC50:  696nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647663(US20240025912, Compound 1-2 | (5S)-5-(3,5-difluoro...)
Affinity DataEC50:  22.8nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647664(US20240025912, Compound 1-62 | (S)-3-(5-(3-chlorop...)
Affinity DataEC50:  98.6nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647665(US20240025912, Compound 1-3 | (5S)-5-(3,5-difluoro...)
Affinity DataEC50:  34.8nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647666(US20240025912, Compound 1-63 | (S)-5-(3-chlorophen...)
Affinity DataEC50:  68.1nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647667(US20240025912, Compound 1-4 | (5S)-2-(bicyclo[2.1....)
Affinity DataEC50:  31.1nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647668(US20240025912, Compound 1-64 | (S)-3-(5-(3,5-diflu...)
Affinity DataEC50:  395nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647669(US20240025912, Compound 1-5 | 3-[(5S)-5-(3,5-diflu...)
Affinity DataEC50:  14.8nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647670(US20240025912, Compound 1-65 | (R)-3-(5-(3,5-diflu...)
Affinity DataEC50:  21.1nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647671(US20240025912, Compound 1-6 | (5S)-2-(3-fluorobicy...)
Affinity DataEC50:  51.2nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647672(US20240025912, Compound 1-66 | (S)-2-(3-fluorobicy...)
Affinity DataEC50:  85.8nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647673(US20240025912, Compound 1-7 | (5S)-2-(bicyclo[1.1....)
Affinity DataEC50:  98.4nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647674(US20240025912, Compound 1-67 | (S)-4-(2-(3-fluorob...)
Affinity DataEC50:  279nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647675(US20240025912, Compound 1-8 | (5S)-2-(3-chlorobicy...)
Affinity DataEC50:  21.8nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647676(US20240025912, Compound 1-68 | (S)-2-(3-fluorobicy...)
Affinity DataEC50:  59.5nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647677(US20240025912, Compound 1-9 | (5S)-2-(3-fluorobicy...)
Affinity DataEC50:  26.1nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647678(US20240025912, Compound 1-69 | 3-((5S,7R)-5-(3,5-d...)
Affinity DataEC50:  263nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647679(US20240025912, Compound 1-10 | (5S)-2-(3-fluorobic...)
Affinity DataEC50:  272nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647680(US20240025912, Compound 1-70 | 3-((5S,7S)-5-(3,5-d...)
Affinity DataEC50:  68.5nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647681(US20240025912, Compound 1-11 | 3-[(5S)-5-(5-fluoro...)
Affinity DataEC50:  300nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647682(US20240025912, Compound 1-71 | (S)-2-(3-chlorobicy...)
Affinity DataEC50:  162nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647683(US20240025912, Compound 1-12 | (5S)-5-(3,5-difluor...)
Affinity DataEC50:  49.1nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647684(US20240025912, Compound 1-72 | (S)-5-(3-chloro-5-f...)
Affinity DataEC50:  21.2nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647685(US20240025912, Compound 1-13 | (5S)-5-(5-fluoropyr...)
Affinity DataEC50:  514nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647686(US20240025912, Compound 1-73 | (S)-5-(3,5-difluoro...)
Affinity DataEC50:  28.2nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647687(US20240025912, Compound 1-14 | (5S)-5-(3,5-difluor...)
Affinity DataEC50:  152nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647688(US20240025912, Compound 1-74 | (S)-5-(2,6-difluoro...)
Affinity DataEC50:  20.9nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647689(US20240025912, Compound 1-15 | (5S)-2-(3-chlorobic...)
Affinity DataEC50:  111nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647690(US20240025912, Compound 1-75 | (S)-5-(4-chloro-3-f...)
Affinity DataEC50:  17.1nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647691(US20240025912, Compound 1-16 | (S)-2-(3-fluorobicy...)
Affinity DataEC50:  23.1nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647692(US20240025912, Compound 1-76 | (S)-2-(3-fluorobicy...)
Affinity DataEC50:  27.5nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647693(US20240025912, Compound 1-17 | 3-[(5S)-3-oxo-5-phe...)
Affinity DataEC50:  36.9nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647694(US20240025912, Compound 1-77 | (S)-5-(4-chloro-3,5...)
Affinity DataEC50:  16.7nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647695(US20240025912, Compound 1-18 | methyl 3-[(5S)-5-(3...)
Affinity DataEC50:  114nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647696(US20240025912, Compound 1-78 | (R)-2-(3-fluorobicy...)
Affinity DataEC50:  93.9nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647697(US20240025912, Compound 1-19 | methyl 3-[(5S)-3-ox...)
Affinity DataEC50:  289nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM647698(US20240025912, Compound 1-79 | (R)-3-(5-(3,5-diflu...)
Affinity DataEC50:  108nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

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