Compile Data Set for Download or QSAR
Report error Found 798 for UniProtKB: Q13936
LigandChemical structure of BindingDB Monomer ID 50227255BDBM50227255(CHEMBL102907)
Affinity DataIC50: 0.00810nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227481BDBM50227481(CHEMBL286157)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227261BDBM50227261(CHEMBL317044)
Affinity DataIC50: 0.0130nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227259BDBM50227259(CHEMBL441428)
Affinity DataIC50: 0.0150nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227474BDBM50227474(CHEMBL286598)
Affinity DataIC50: 0.0170nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227478BDBM50227478(CHEMBL37402)
Affinity DataIC50: 0.0220nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227256BDBM50227256(CHEMBL103806)
Affinity DataIC50: 0.0270nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227480BDBM50227480(CHEMBL37899)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227476BDBM50227476(CHEMBL204616)
Affinity DataIC50: 0.0330nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227479BDBM50227479(CHEMBL35368)
Affinity DataIC50: 0.0450nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227473BDBM50227473(CHEMBL1099207)
Affinity DataIC50: 0.0460nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227475BDBM50227475(CHEMBL285868)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227257BDBM50227257(CHEMBL321999)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50318494BDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50318494BDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  0.25nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227262BDBM50227262(CHEMBL105444)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50318494BDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKd:  0.260nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel in guinea pig ventricular myocardium membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50318494BDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of voltage-gated L-type Ca channel (species unknown)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227477BDBM50227477(CHEMBL35123)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50336640BDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataKd:  0.400nMAssay Description:Displacement of [3H]nitrendipine from dihydropyridine receptor of guinea pig myocardial membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50336640BDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50016400BDBM50016400(CHEMBL159854 | 2,6-Dimethyl-4-(2-methylsulfanyl-3-...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50318494BDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50: 1nMAssay Description:In vitro vasorelaxant activity (calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227260BDBM50227260(CHEMBL319033)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50228791BDBM50228791(CHEMBL329897)
Affinity DataIC50: 1.5nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50228797BDBM50228797(CHEMBL89260)
Affinity DataIC50: 1.70nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50228807BDBM50228807(CHEMBL2092901)
Affinity DataIC50: 2nMAssay Description:In vitro vasorelaxant activity (calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 327851BDBM327851(US9663479, Formula 2 peak 2 (chiral))
Affinity DataIC50: 2.10nMAssay Description:This section describes a scintillation proximity assay (SPA) to measure [3H] gabapentin ([3H]GBP) binding to membranes containing α2δ-1 and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50436176BDBM50436176(Dynacirc | Dynacirc Cr | Isrodipine | PN-200-110 |...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227258BDBM50227258(CHEMBL102498)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50228801BDBM50228801(CHEMBL89049)
Affinity DataIC50: 2.60nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227245BDBM50227245(CHEMBL3392281)
Affinity DataKd:  2.60nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel in guinea pig ventricular myocardium membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50228811BDBM50228811(CHEMBL84906)
Affinity DataIC50: 2.70nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227254BDBM50227254(CHEMBL318521)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50101963BDBM50101963(CHEBI:76917 | BAY-K-5552 | Nisoldipine | Sular)
Affinity DataIC50: 3nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Chinese hamster ovary cells heterologically expressing alpha-1C subu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50228808BDBM50228808(CHEMBL86415)
Affinity DataIC50: 3.10nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50228810BDBM50228810(CHEMBL89904)
Affinity DataIC50: 3.60nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50227246BDBM50227246(CHEMBL3392282)
Affinity DataIC50: 4nMAssay Description:In vitro vasorelaxant activity (calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50079458BDBM50079458(2,6-Dimethyl-4-[3-methyl-5-(2-naphthalen-1-yl-ethy...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H](+)-PN200-110 binding to calcium channels in guinea pig cardiac membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 327848BDBM327848(US9663479, Formula 2 (Racemic))
Affinity DataIC50: 4.20nMAssay Description:This section describes a scintillation proximity assay (SPA) to measure [3H] gabapentin ([3H]GBP) binding to membranes containing α2δ-1 and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50035794BDBM50035794(4-Methyl-2-methylsulfanyl-13-nitro-3,8,9,10,11,16b...)
Affinity DataKd:  5nMAssay Description:Displacement of [3H]nitrendipine from dihydropyridine receptor of guinea pig myocardial membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50228804BDBM50228804(CHEMBL89175)
Affinity DataIC50: 5.20nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50079463BDBM50079463(4-{5-[2-(3-Bromo-phenyl)-ethyl]-3-phenyl-isoxazol-...)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H](+)-PN200-110 binding to calcium channels in guinea pig cardiac membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50101817BDBM50101817(CHEBI:7565 | Adalat | Adalat Cc | Afeditab Cr | BA...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50228812BDBM50228812(CHEMBL315125)
Affinity DataIC50: 11nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50226760BDBM50226760(CHEMBL2398396)
Affinity DataKd:  12nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel in guinea pig ventricular myocardium membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50228796BDBM50228796(CHEMBL330707)
Affinity DataIC50: 14nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50013025BDBM50013025(CHEMBL305903 | 2,6-Dimethyl-4-(5-methyl-3-phenyl-i...)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]PN-200110 binding to Calcium channel in guinea pig heart membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50228795BDBM50228795(CHEMBL315298)
Affinity DataIC50: 17nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50228790BDBM50228790(CHEMBL440695)
Affinity DataIC50: 17nMAssay Description:In vitro vasorelaxant activity (calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2019
Entry Details Article
PubMed
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