Compile Data Set for Download or QSAR
Report error Found 248 for UniProtKB: Q15750
LigandChemical structure of BindingDB Monomer ID 50557619BDBM50557619(CHEMBL4796239)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 254948BDBM254948(US9505765, 38)
Affinity DataIC50: 3.10nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50438224BDBM50438224(CHEMBL2407759)
Affinity DataIC50: 4nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 254963BDBM254963(US9505765, 187)
Affinity DataIC50: 4.30nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 254964BDBM254964(US9505765, 188)
Affinity DataIC50: 4.40nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50557620BDBM50557620(CHEMBL4752978)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 254968BDBM254968(US9505765, 192)
Affinity DataIC50: 5.20nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 254962BDBM254962(US9505765, 186)
Affinity DataIC50: 7nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50187114BDBM50187114(CHEMBL3823303)
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50042034BDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 8nMAssay Description:Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50187114BDBM50187114(CHEMBL3823303)
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50191935BDBM50191935(CHEMBL1761718)
Affinity DataIC50: 8.90nMAssay Description:Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50042034BDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 9nMAssay Description:Inhibition of full length TAK1/TAB1 (unknown origin) using biotin-MKK6 as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50042034BDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Tak1/Tab1 (unknown origin) assessed as inhibition of Tak1 kinase activity preincubated for 30 mins followed by addition of MBP protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50042034BDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 9nMAssay Description:Inhibition of full length TAK1/TAB1 (unknown origin) using biotin-MKK6 as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50438335BDBM50438335(CHEMBL2408610)
Affinity DataIC50: 9nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50438317BDBM50438317(CHEMBL2408611)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 414418BDBM414418(US10434085, Compound (5Z)-7-oxozeaenol | 5Z-7-Oxoz...)
Affinity DataIC50: 11nMAssay Description:The assay was performed at BSP Biosience Inc. (5Z)-7-oxozeaenol was used as a positive control. Analogue 3 was not tested due to the short-term stabi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 254971BDBM254971(US9505765, 195)
Affinity DataIC50: 13nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50438223BDBM50438223(CHEMBL2407758)
Affinity DataIC50: 13nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50438329BDBM50438329(CHEMBL2408616)
Affinity DataIC50: 14nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 254975BDBM254975(US9505765, 199)
Affinity DataIC50: 16nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50438331BDBM50438331(CHEMBL2408615)
Affinity DataIC50: 17nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50438219BDBM50438219(CHEMBL2407761)
Affinity DataIC50: 18nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 254965BDBM254965(US9505765, 189)
Affinity DataIC50: 19nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50191939BDBM50191939(CHEMBL1761588)
Affinity DataIC50: 21nMAssay Description:Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50438222BDBM50438222(CHEMBL2407757)
Affinity DataIC50: 23nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50438317BDBM50438317(CHEMBL2408611)
Affinity DataIC50: 28nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187111BDBM50187111(CHEMBL3823738)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50438221BDBM50438221(CHEMBL2407760)
Affinity DataIC50: 30nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50129131BDBM50129131(CHEBI:83275 | Hypothemycin | US10434085, Compound ...)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged TAK1 (1 to 303 residues)/TAB1 (437 to end residues) expressed in baculovirus infected Sf9 insec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50438330BDBM50438330(CHEMBL2408614)
Affinity DataIC50: 31nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 254967BDBM254967(US9505765, 191)
Affinity DataIC50: 33nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50129131BDBM50129131(CHEBI:83275 | Hypothemycin | US10434085, Compound ...)
Affinity DataIC50: 33nMAssay Description:The assay was performed at BSP Biosience Inc. (5Z)-7-oxozeaenol was used as a positive control. Analogue 3 was not tested due to the short-term stabi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetTGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 35nMAssay Description:Inhibition of TAB1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50529793BDBM50529793(CHEMBL4586372)
Affinity DataIC50: 37nMAssay Description:Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50529793BDBM50529793(CHEMBL4586372)
Affinity DataIC50: 37nMAssay Description:Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50529792BDBM50529792(CHEMBL4535889)
Affinity DataIC50: 41nMAssay Description:Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50529792BDBM50529792(CHEMBL4535889)
Affinity DataIC50: 41nMAssay Description:Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 254949BDBM254949(US9505765, 39)
Affinity DataIC50: 41nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50191941BDBM50191941(CHEMBL1761586)
Affinity DataIC50: 42nMAssay Description:Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50191785BDBM50191785(CHEMBL1761585)
Affinity DataIC50: 46nMAssay Description:Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 254970BDBM254970(US9505765, 194)
Affinity DataIC50: 51nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50512333BDBM50512333(CHEMBL4443805)
Affinity DataIC50: 54nMAssay Description:Inhibition of tracer 222 binding to recombinant full-length human His-tagged MAP3K7/MAP3K7IP1 (437 to 504 residues) expressed in baculovirus expressi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50438211BDBM50438211(CHEMBL2407795)
Affinity DataIC50: 61nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 254969BDBM254969(US9505765, 193)
Affinity DataIC50: 75nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 414427BDBM414427(US10434085, Compound 5)
Affinity DataIC50: 77nMAssay Description:The assay was performed at BSP Biosience Inc. (5Z)-7-oxozeaenol was used as a positive control. Analogue 3 was not tested due to the short-term stabi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50438220BDBM50438220(CHEMBL2407792)
Affinity DataIC50: 89nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 254961BDBM254961(US9505765, 184)
Affinity DataIC50: 97nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

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