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TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  0.300nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  210nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  34nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  190nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  190nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataKd:  2.00E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  1.70E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  220nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  600nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  17nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  5.10E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  200nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  0.300nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  9.30nMAssay Description:Binding affinity to human TrkCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50505005(CHEMBL4455810)
Affinity DataEC50:  330nMAssay Description:Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50505010(CHEMBL4455143)
Affinity DataEC50:  180nMAssay Description:Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50505011(CHEMBL4529332)
Affinity DataEC50:  170nMAssay Description:Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50505012(CHEMBL4472787)
Affinity DataEC50:  330nMAssay Description:Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50505013(CHEMBL4574315)
Affinity DataEC50:  220nMAssay Description:Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50505014(CHEMBL4467829)
Affinity DataEC50:  480nMAssay Description:Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50505017(CHEMBL4462161)
Affinity DataEC50:  90nMAssay Description:Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50505009(CHEMBL4542212)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50505019(CHEMBL4465865)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50505016(CHEMBL4527488)
Affinity DataEC50:  510nMAssay Description:Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50505015(CHEMBL4538772)
Affinity DataEC50:  190nMAssay Description:Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  19nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged NTRK3 (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  23nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged NTRK3 (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50506718(CHEMBL1098827)
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to human partial length TRKC (Q531 to G825 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50528539(CHEMBL4553037)
Affinity DataKd:  18nMAssay Description:Binding affinity to TrkC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50528539(CHEMBL4553037)
Affinity DataKd:  18nMAssay Description:Binding affinity to wild type human partial length TRKC (531 to 825 residues) expressed in mammalian expression system preincubated for 1 hr measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50528539(CHEMBL4553037)
Affinity DataKd:  18nMAssay Description:Binding affinity to wild type human partial length TRKC (531 to 825 residues) expressed in mammalian expression system preincubated for 1 hr measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50565310(CHEMBL4792981)
Affinity DataKd:  4.90nMAssay Description:Binding affinity to wild-type human partial length TRKC (Q531 to G825 residues) expressed in mammalian expression system by Kinomescan method relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50565738(CHEMBL4794404)
Affinity DataEC50:  29nMAssay Description:Inhibition of TEL fused wild type TRKC (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y516 residue afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50299148(1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...)
Affinity DataKd:  200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  14nMAssay Description:Binding affinity to TRKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to TRKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd:  550nMAssay Description:Binding affinity to TRKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50326054(CHEMBL1240703)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to TRKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  600nMAssay Description:Binding affinity to TRKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  5.10E+3nMAssay Description:Binding affinity to TRKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to TRKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  32nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  14nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  17nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  1.70E+3nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM24654(pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  200nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM50309910(N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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