Compile Data Set for Download or QSAR
Report error Found 727 of affinity data for UniProtKB/TrEMBL: Q16288
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human TRKC using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM139540(US8889696, Staurosporine | US9051313, Staurosporin...)
Affinity DataIC50: 0.106nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.123nMAssay Description:Inhibition of human TRKC using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TRKC (unknown origin) using TK as substrate in presence of ATP incubated for 40 mins by HTRF KinEASE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581357(CHEMBL5093999)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581355(CHEMBL5070835)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581356(CHEMBL5080010)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50579500(CHEMBL4864729)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of TRKC (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50579500(CHEMBL4864729)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50631772(CHEMBL5400169)
Affinity DataIC50: 0.211nMAssay Description:Inhibition of His-tagged human recombinant wild type TRKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of human TRKC using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM769500((3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,...)
Affinity DataIC50: 0.220nMAssay Description:Table 1: The experimental methods were operated according to the steps in the kit instruction, and were briefly described as follows: a test compound...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.290nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.290nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  0.300nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  0.300nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.320nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM769502((3R,11R)-6-fluoro-11-(methoxymethyl)-3-methyl- 10...)
Affinity DataIC50: 0.370nMAssay Description:Table 1: The experimental methods were operated according to the steps in the kit instruction, and were briefly described as follows: a test compound...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.410nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.440nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.450nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM769495((3R,11R)-6-fluoro-3-methyl-10-oxa-2,14,18,19,22- ...)
Affinity DataIC50: 0.470nMAssay Description:Table 1: The experimental methods were operated according to the steps in the kit instruction, and were briefly described as follows: a test compound...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM769494((3R)-6-fluoro-3-methyl-10-oxa-2,13,17,18,21-pentaa...)
Affinity DataIC50: 0.5nMAssay Description:Table 1: The experimental methods were operated according to the steps in the kit instruction, and were briefly described as follows: a test compound...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775583(US12435089, Example 52)
Affinity DataIC50: 0.5nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775588(US12435089, Example 66)
Affinity DataIC50: 0.5nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775590(US12435089, Example 68)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775581(US12435089, Example 50)
Affinity DataIC50: 0.5nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775585(US12435089, Example 54)
Affinity DataIC50: 0.5nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775584(US12435089, Example 55)
Affinity DataIC50: 0.5nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775561(US12435089, Example 4)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775586(US12435089, Example 57)
Affinity DataIC50: 0.5nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775582(US12435089, Example 51)
Affinity DataIC50: 0.5nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775563(US12435089, Example 9)
Affinity DataIC50: 0.5nMAssay Description:Serial dilutions of the compound were prepared with 10% DMSO, and 5 μl of each dilution was added to a 50 μl reaction vessel to result in a...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775562(US12435089, Example 5)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50649925(CHEMBL5624610 | US12435089, Example 10)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775591(US12435089, Example 69)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775572(US12435089, Example 28)
Affinity DataIC50: 0.5nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM775587(US12435089, Example 65)
Affinity DataIC50: 0.5nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM164901(US9067914, Ex. 3-15 | US10166239, Ex. 3-15 | US114...)
Affinity DataIC50: 0.503nMAssay Description:Human TrkC, catalytic domain [456-825(end) amino acids of accession number NP-002521.2] was expressed as N-terminal GST-fusion protein (69 kDa) using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM164901(US9067914, Ex. 3-15 | US10166239, Ex. 3-15 | US114...)
Affinity DataIC50: 0.503nMAssay Description:Human TrkC, catalytic domain [456-825(end) amino acids of accession number NP_002521.2] was expressed as N-terminal GST-fusion protein (69 kDa) using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM164901(US9067914, Ex. 3-15 | US10166239, Ex. 3-15 | US114...)
Affinity DataIC50: 0.503nMAssay Description:Human TrkC, catalytic domain [456-825 (end) amino acids of accession number NP_002521.2] was expressed as N-terminal GST-fusion protein (69 kDa) usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM164901(US9067914, Ex. 3-15 | US10166239, Ex. 3-15 | US114...)
Affinity DataIC50: 0.503nMAssay Description:Human TrkC, catalytic domain [456-825(end) amino acids of accession number NP_002521.2] was expressed as N-terminal GST-fusion protein (69 kDa) using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM769507((3R)-6-chloro-3,11-dimethyl-10-oxa-2,13,17,18,21-p...)
Affinity DataIC50: 0.520nMAssay Description:Table 1: The experimental methods were operated according to the steps in the kit instruction, and were briefly described as follows: a test compound...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 0.525nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.550nMAssay Description:The compound powder was dissolved in 100% DMSO (Sigma, Cat. D8418-1l) to prepare a 10 mM storage solution. The compounds had an initial test concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM669891(US20240132517, Comparative Compound 42 | US1212925...)
Affinity DataIC50: 0.610nMAssay Description:The compound powder was dissolved in 100% DMSO (Sigma, Cat. D8418-1l) to prepare a 10 mM storage solution. The compounds had an initial test concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

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