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TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324510(1-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl...)
Affinity DataKi:  0.0860nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324512(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl-N-...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324500(1-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324524((6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylim...)
Affinity DataKi:  0.420nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324513(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl-N-...)
Affinity DataKi:  0.580nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324511(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl-N-...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324508(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl-N-...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324494(6-(aminomethyl)-5-(2,4-dichlorophenyl)-N-(1,3-dime...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442191(CHEMBL2441846)
Affinity DataKi:  0.800nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324504(6-(aminomethyl)-5-(2,4-dichlorophenyl)-N,7-dimethy...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442193(CHEMBL2441844)
Affinity DataKi:  1nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442193(CHEMBL2441844)
Affinity DataKi:  1nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442183(CHEMBL2441955)
Affinity DataKi:  1nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324505(6-(aminomethyl)-5-(2,4-dichlorophenyl)-N,7-dimethy...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324497((6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylim...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50389480(CHEMBL2063040)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324507(6-(aminomethyl)-5-(2,4-dichlorophenyl)-N-(furan-2-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324501(6-(aminomethyl)-5-(2,4-dichlorophenyl)-N-(1-ethyl-...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324522((6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylim...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324506(6-(aminomethyl)-5-(2,4-dichlorophenyl)-N-(furan-2-...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442184(CHEMBL2441954)
Affinity DataKi:  1.40nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442198(CHEMBL2441839)
Affinity DataKi:  1.40nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50050513(Ketopyrrolidine derivative | (R)-1-((S)-2-amino-3-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant DPP8 expressed in HEK293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324499(6-(aminomethyl)-5-(2,4-dichlorophenyl)-N-(isoxazol...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324515(6-(aminomethyl)-5-(2,4-dichlorophenyl)-N,N-diethyl...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442200(CHEMBL2441837)
Affinity DataKi:  1.70nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442192(CHEMBL2441845)
Affinity DataKi:  1.80nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM514540(US11096924, DASH-inhibitors 5320 | US11583516, Cmp...)
Affinity DataIC50: 1.90nMAssay Description:Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human recombinant DPP8 using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM514540(US11096924, DASH-inhibitors 5320 | US11583516, Cmp...)
Affinity DataIC50: 1.90nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50050525((R)-1-((S)-2-aminopropanoyl)pyrrolidin-2-ylboronic...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant DPP8 expressed in HEK293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324523(N-((3S)-1-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-...)
Affinity DataKi:  2nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442185(CHEMBL2441953)
Affinity DataKi:  2nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324518(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl-N-...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324525(6-(aminomethyl)-5-(2,4-dichlorophenyl)-N,7-dimethy...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324516((6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylim...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324509(N-(2-(1H-imidazol-4-yl)ethyl)-6-(aminomethyl)-5-(2...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324495(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl-N-...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324517((6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylim...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324503(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl-N-...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50612314(CHEMBL5279548)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of DPP-8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM142093(US8933056, Chg-boroPro Thioxamide | US8933056, Chg...)
Affinity DataIC50: 2.70nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetDipeptidyl peptidase 8/9(Human)
Tufts College

US Patent
LigandPNGBDBM514515(US11096924, DASH-inhibitors 3102 C | US11583516, C...)
Affinity DataIC50: 2.70nMAssay Description:Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDipeptidyl peptidase 8/9(Human)
Tufts College

US Patent
LigandPNGBDBM514515(US11096924, DASH-inhibitors 3102 C | US11583516, C...)
Affinity DataIC50: 2.70nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442181(CHEMBL2441829)
Affinity DataKi:  2.80nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324521(4-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50324496(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl-N-...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of human DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM589767(US11559537, Compound 5322)
Affinity DataIC50: 3nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50050511((R)-1-(2-aminoacetyl)pyrrolidin-2-ylboronic acid |...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of human recombinant DPP8 expressed in HEK293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50050513(Ketopyrrolidine derivative | (R)-1-((S)-2-amino-3-...)
Affinity DataIC50: 3.60nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

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