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Report error Found 1420 of affinity data for UniProtKB/TrEMBL: Q8NI77
TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695597(US12084420, Compound 151 | N-(1$#8243;-(3-((2-azas...)
Affinity DataKi:  0.120nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636877(US20230382889, Compound 11 | N-(4-(4-(6-(4,4-diflu...)
Affinity DataKi:  0.130nMAssay Description:Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636903(US20230382889, Compound 47 | N-(4-(4-(2-(4,4-diflu...)
Affinity DataKi:  0.200nMAssay Description:Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636901(US20230382889, Compound 45 | N-(4-(4-(6-(4,4-diflu...)
Affinity DataKi:  0.210nMAssay Description:Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695618(US12084420, Compound 182 | N-(1-methylcyclobutyl)-...)
Affinity DataKi:  0.260nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695639(US12084420, Compound 223 | N-(bicyclo[1.1.1]pentan...)
Affinity DataKi:  0.260nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695645(US12084420, Compound 229 | N-(1$#8243;-(3- (cyclop...)
Affinity DataKi:  0.290nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695559(US12084420, Compound 24b)
Affinity DataKi:  0.290nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695595(US12084420, Compound 148 | N-(tert-butyl)-3-(5$#82...)
Affinity DataKi:  0.290nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695669(US12084420, Compound 262 | N-(tert-butyl)-4-(5$#82...)
Affinity DataKi:  0.310nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695588(US12084420, Compound 134 | N-(tert-butyl)-3-(5$#82...)
Affinity DataKi:  0.340nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695692(US12084420, Compound 297 | N-(tert-butyl)-2-methox...)
Affinity DataKi:  0.380nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695693(US12084420, Compound 298 | N-(tert-butyl)-2-hydrox...)
Affinity DataKi:  0.380nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695650(US12084420, Compound 237 | N-(1$#8243;-(3-((6,6-di...)
Affinity DataKi:  0.440nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695729(US12084420, Compound 333a)
Affinity DataKi:  0.470nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695780(US12084420, Compound 140a)
Affinity DataKi:  0.5nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636881(US20230382889, Compound 15 | N-(4-(4-(6-(4,4-diflu...)
Affinity DataKi:  0.520nMAssay Description:Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636927(US20230382889, Compound 69 | N-(4-(4-(2-(4,4-diflu...)
Affinity DataKi:  0.530nMAssay Description:Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695558(US12084420, Compound 24a)
Affinity DataKi:  0.540nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695602(US12084420, Compound 160 | N-(tert-butyl)-3-(5$#82...)
Affinity DataKi:  0.540nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695555(US12084420, Compound 22 | N-(tert-butyl)-3-(5$#824...)
Affinity DataKi:  0.550nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695719(US12084420, Compound 320 | N-(1$#8243;-(3-((1-oxa-...)
Affinity DataKi:  0.570nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695623(US12084420, Compound 192 | N-(3,3-difluorocyclobut...)
Affinity DataKi:  0.640nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695730(US12084420, Compound 333b)
Affinity DataKi:  0.770nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636926(US20230382889, Compound 68 | N-(4-(4-(6-(4,4-diflu...)
Affinity DataKi:  0.820nMAssay Description:Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695601(US12084420, Compound 159 | N-(tert-butyl)-2-fluoro...)
Affinity DataKi:  0.830nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695665(US12084420, Compound 257 | N-(1$#8243;-(3-((3,3-di...)
Affinity DataKi:  0.960nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

LigandPNGBDBM762886(2-Hydroxy-N-(4-(5-(6-methyl-2-(3,3,3-trifluoroprop...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762888(N-(4-(5-(2-(4,4-Difluoropiperidin-1-yl)-6-methylpy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762896(N-(4-(5-(2-(6,6-Difluoro-3-azabicyclo[3.1.0]hexan-...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762883(N-(4-(5-(2-(3,3-Difluoropiperidin-1-yl)-6-methylpy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695651(US12084420, Compound (R)-239)
Affinity DataKi:  1.40nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695781(US12084420, Compound 140b)
Affinity DataKi:  1.40nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636871(US20230382889, Compound 5 | N-(4-(5-(6-(4,4-difluo...)
Affinity DataKi:  1.5nMAssay Description:Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636917(US20230382889, Compound 59 | N-(5-(4-(6-(4,4-diflu...)
Affinity DataIC50: 1.60nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636925(US20230382889, Compound 67 | N-(4-(4-(2-(4,4-diflu...)
Affinity DataKi:  1.70nMAssay Description:Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695552(US12084420, Compound 19 | N-(1'-(3-((4,4-difluorop...)
Affinity DataKi:  1.80nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695603(US12084420, Compound 162a)
Affinity DataKi:  1.90nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

LigandPNGBDBM762918(N-(4-(4-(2-(3,3-Difluoropiperidin-1-yl)-6-methylpy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762890(N-(4-(5-(2-(4,4-Difluoropiperidin-1-yl)-6-methylpy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762906(N-(4-(5-(2-(4-Fluoropiperidin-1-yl)-6-methylpyridi...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762910(N-(4-(4-(2-(4,4-Difluorocyclohexyl)-6-methylpyrimi...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695599(US12084420, Compound 155 | N-(1$#8243;-(3- (cyclop...)
Affinity DataKi:  2nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

LigandPNGBDBM762880(N-(4-(5-(2-(4,4-Difluoropiperidin-1-yl)-6-methylpy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762912(US20250250264, Compound I-112)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762897(N-(4-(4-(2-(4,4-Difluoropiperidin-1-yl)-6-ethylpyr...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762884(N-(4-(5-(2-(4-fluoropiperidin-1-yl)-6-methylpyrimi...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636907(US20230382889, Compound 51 | US20230382889, Compou...)
Affinity DataIC50: 2.40nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636907(US20230382889, Compound 51 | US20230382889, Compou...)
Affinity DataIC50: 2.80nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM637003(US20230382889, Compound 144 | N-(4-(4-(6-(4,4-difl...)
Affinity DataIC50: 2.80nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

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