Compile Data Set for Download or QSAR
maximum 50k data
Found 50 for UniProtKB: Q92547
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
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In DepthDetails US Patent
LigandPNGBDBM411573(2-amino-6-fluoro-N-(4-(4-(oxetan-3-yl)piperazin-1-...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM412042(2-amino-6-fluoro-N-(5-fluoro-4-(4-(piperazine-1-ca...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM412037(US10392391, Compound I-G-7 | US10787452, Compound ...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM412034(2-amino-6-fluoro-N-(5-fluoro-4-(4-(4-methylpiperaz...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM412025(US10392391, Compound I-C-79 | US10787452, Compound...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
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In DepthDetails US Patent
LigandPNGBDBM411989(US10392391, Compound I-C-43 | US10787452, Compound...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411977(US10392391, Compound I-C-31 | US10787452, Compound...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411971(US10392391, Compound I-C-25 | US10787452, Compound...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411840(US10392391, Compound I-N-275 | US10787452, Compoun...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411749(US10392391, Compound I-N-182 | US10392391, Compoun...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411733(US10392391, Compound I-N-166 | US10787452, Compoun...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411686(US10392391, Compound I-N-118 | US10787452, Compoun...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411629(US10392391, Compound I-N-58 | US10787452, Compound...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411584(US10392391, Compound I-N-13 | US10787452, Compound...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM412050(US10392391, Compound I-G-21 | US10787452, Compound...)
Affinity DataKi: <20nMAssay Description:Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM412050(US10392391, Compound I-G-21 | US10787452, Compound...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails US Patent
LigandPNGBDBM412042(2-amino-6-fluoro-N-(5-fluoro-4-(4-(piperazine-1-ca...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM560106(US11370798, Cmpd. # I-G-7 | US20230271963, Compoun...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM412034(2-amino-6-fluoro-N-(5-fluoro-4-(4-(4-methylpiperaz...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM412025(US10392391, Compound I-C-79 | US10787452, Compound...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails US Patent
LigandPNGBDBM411989(US10392391, Compound I-C-43 | US10787452, Compound...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411977(US10392391, Compound I-C-31 | US10787452, Compound...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411971(US10392391, Compound I-C-25 | US10787452, Compound...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411840(US10392391, Compound I-N-275 | US10787452, Compoun...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411749(US10392391, Compound I-N-182 | US10392391, Compoun...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411733(US10392391, Compound I-N-166 | US10787452, Compoun...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411686(US10392391, Compound I-N-118 | US10787452, Compoun...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411629(US10392391, Compound I-N-58 | US10787452, Compound...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411584(US10392391, Compound I-N-13 | US10787452, Compound...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM411573(2-amino-6-fluoro-N-(4-(4-(oxetan-3-yl)piperazin-1-...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50076922(1,11-dihydroxy-6-(2-hydroxy-1-hydroxymethylethylam...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083613(1,9-dihydroxy-6-(2-hydroxy-1-hydroxymethylethylami...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083606(1-hydroxy-6-(2-hydroxy-1-hydroxymethylethylamino)-...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083609(1,10-dihydroxy-6-(2-hydroxy-1-hydroxymethylethylam...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083610(1,9-dihydroxy-6-(2-hydroxy-1-hydroxymethylethylami...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083607(1,10-dihydroxy-6-(2-hydroxy-1-hydroxymethylethylam...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083603(3,9-dihydroxy-6-(2-hydroxy-1-hydroxymethylethylami...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083611(3-hydroxy-6-(2-hydroxy-1-hydroxymethylethylamino)-...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083599(1,3,10-trihydroxy-6-(2-hydroxy-1-hydroxymethylethy...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083604(2,9-dihydroxy-6-(2-hydroxy-1-hydroxymethylethylami...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083600(2,10-dihydroxy-6-(2-hydroxy-1-hydroxymethylethylam...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083608(2,9-dihydroxy-6-(2-hydroxy-1-hydroxymethylethylami...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083605(3-hydroxy-6-(2-hydroxy-1-hydroxymethylethylamino)-...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083601(1-hydroxy-6-(2-hydroxy-1-hydroxymethylethylamino)-...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083597(4-hydroxy-6-(2-hydroxy-1-hydroxymethylethylamino)-...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083598(2-hydroxy-6-(2-hydroxy-1-hydroxymethylethylamino)-...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083614(1,3,9,11-tetrahydroxy-6-(2-hydroxy-1-hydroxymethyl...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-binding protein 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083602(2-hydroxy-6-(2-hydroxy-1-hydroxymethylethylamino)-...)
Affinity DataEC50: >5.00E+4nMAssay Description:In vitro inhibition of Topoisomerase II-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed