Compile Data Set for Download or QSAR
Report error Found 13635 of affinity data for UniProtKB/TrEMBL: Q92918
LigandPNGBDBM50569664(CHEMBL4859451)
Affinity DataIC50: 0.00500nMAssay Description:Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50598494(CHEMBL5171022)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of HPK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM529791(US11203591, Example 198)
Affinity DataIC50: 0.0100nMAssay Description:Ten nanoliters of test compounds dissolved in DMSO at various concentrations were dispensed into a 384-well ProxiPlate (PerkinElmer #6008289). Five m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
US Patent

LigandPNGBDBM548828(WO2022098806, Compound 2-89)
Affinity DataIC50: 0.0100nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2022
Entry Details
WIPO WO2022098806

LigandPNGBDBM548859(WO2022098806, Compound 2-120)
Affinity DataIC50: 0.0100nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2022
Entry Details
WIPO WO2022098806

LigandPNGBDBM50569664(CHEMBL4859451)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human HPK1 catalytic domain (1 to 346 residues) using His-tagged SLP76 as substrate assessed as reduction in substrate phosphorylation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM548847(WO2022098806, Compound 2-108)
Affinity DataIC50: 0.0100nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2022
Entry Details
WIPO WO2022098806

LigandPNGBDBM762547(2-[[6-(5-amino-4-methyl-3-pyridyl)-7-fluoro-3- iso...)
Affinity DataKi:  0.0100nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762563(tert-butyl 7-[7-fluoro-3-[(6-methyl-7-oxo-5,8- dih...)
Affinity DataKi:  0.0100nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM598166(US11612606, Compound 522a | (1R,5S,6s)-3-(Methylsu...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM762605(2-((6-(5-amino-4-methylpyridin-3-yl)-7- fluoroisoq...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM598170(US11612606, Compound 525a | (1s,3s)-3-(3-Fluoroaze...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM762604(N-(6-(5-amino-4-methylpyridin-3-yl)-7- fluoroisoqu...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM598177(US11612606, Compound 528a | (1s,3s)-3-Methoxy-3-me...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598150(US11612606, Compound 511a | (R)-8-(Oxetan-3-yl)-8-)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598155(US11612606, Compound 514a | (1r,3r)-3-(1H-Imidazol...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598153(US11612606, Compound 512b | (1r,3s)-3-Ethyl-3-hydr...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598160(US11612606, Compound 517a | (1s,3s)-3-(Azetidine-1...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM762606(2-((6-(5-amino-4-methylpyridin-3-yl)-7- fluoroisoq...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM598159(US11612606, Compound 516b | (3R,4S)-4-Cyclopropylt...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM762609(fluoroisoquinolin-3-yl)amino)-6-(tert-butyl)-4- | ...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM598164(US11612606, Compound 520a | (1s,3s)-3-(Methylcarba...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598197(US11612606, Compound 539a | (1r,3r)-3-(Methylamino...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598204(US11612606, Compound 543a | (1R,5S,6s)-3-Oxabicycl...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM762625(N-(7-fluoro-6-(9-methyl-1,2,3,4- tetrahydropyrido[...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM598210(US11612606, Compound 546a | trans-4-Methoxytetrahy...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM762647((R)-2'-((7-fluoro-6-(8-hydroxy-4-methyl- | US12378...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762648(5,6,7,8-tetrahydro-1,5-naphthyridin-3- | US1237824...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762573(2-((7,8-difluoro-6-(8-methyl-2,3-dihydro-1H- pyrid...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM598192(US11612606, Compound 536b | (1s,3r)-3-(Cyanomethyl...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598191(US11612606, Compound 536a | (1r,3s)-3-(Cyanomethyl...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598189(US11612606, Compound 535a | trans-2-Cyanocyclobuty...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598194(US11612606, Compound 537b | (1r,3r)-3-Cyano-3-meth...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598232(US11612606, Compound 559d | (1S,2S)-2-Methylcyclob...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM762584(1H-pyrido[2,3-b][1,4]oxazin-7-yl)isoquinolin- | US...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM598231(US11612606, Compound 559c | trans-2-Methylcyclobut...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM762585((S)-2-((7-fluoro-6-(8-methyl-2,3-dihydro-1H- | US1...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762586(pyrido[2,3-b][1,4]oxazin-7-yl)isoquinolin-3- | US1...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762669(2'-((6-(5-amino-4-methylpyridin-3-yl)-8- fluoroiso...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762668(2'-((6-(5-amino-4-methylpyridin-3-yl)-7- fluoroiso...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762590(N-(7-fluoro-6-(8-methyl-2,3-dihydro-1H- pyrido[2,3...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762579(N-(7-fluoro-6-(8-methyl-2,3-dihydro-1H- pyrido[2,3...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM762581(2-((7-fluoro-6-(8-methyl-2,3-dihydro-1H- pyrido[2,...)
Affinity DataKi:  0.0130nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM598216(US11612606, Compound 550a | (1r,3r)-3-Morpholinocy...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598215(US11612606, Compound 549b | (1r,3r)-3-(2-Cyanoprop...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598214(US11612606, Compound 549a | (1s,3s)-3-(2-Cyanoprop...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598220(US11612606, Compound 553a | (1s,3s)-3-hydroxycyclo...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598218(US11612606, Compound 551a | (1s,3s)-3-Cyclopropyl-...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598223(US11612606, Compound 555b | (3R,4S)-4-Methyltetrah...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandPNGBDBM598222(US11612606, Compound 555a | trans-4-Methyltetrahyd...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

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