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TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM485817(US10946017, Compound 19)
Affinity DataKd:  725nMAssay Description:In vitro degradation assay protocol for compounds 3-33: Panc02.13 cells were purchased from ATCC and cultured in RPMI-1640 (Gibco), supplemented with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM485818(US10946017, Compound 20)
Affinity DataKd:  10.4nMAssay Description:In vitro degradation assay protocol for compounds 3-33: Panc02.13 cells were purchased from ATCC and cultured in RPMI-1640 (Gibco), supplemented with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM485821(US10946017, Compound 21)
Affinity DataKd:  13nMAssay Description:In vitro degradation assay protocol for compounds 3-33: Panc02.13 cells were purchased from ATCC and cultured in RPMI-1640 (Gibco), supplemented with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM485823(US10946017, Compound 22)
Affinity DataKd:  1.04E+3nMAssay Description:In vitro degradation assay protocol for compounds 3-33: Panc02.13 cells were purchased from ATCC and cultured in RPMI-1640 (Gibco), supplemented with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM485824(US10946017, Compound 23)
Affinity DataKd:  4nMAssay Description:In vitro degradation assay protocol for compounds 3-33: Panc02.13 cells were purchased from ATCC and cultured in RPMI-1640 (Gibco), supplemented with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM485825(US10946017, Compound 24)
Affinity DataKd:  104nMAssay Description:In vitro degradation assay protocol for compounds 3-33: Panc02.13 cells were purchased from ATCC and cultured in RPMI-1640 (Gibco), supplemented with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM485827(US10946017, Compound 25)
Affinity DataKd:  270nMAssay Description:In vitro degradation assay protocol for compounds 3-33: Panc02.13 cells were purchased from ATCC and cultured in RPMI-1640 (Gibco), supplemented with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM485828(US10946017, Compound 26)
Affinity DataKd:  275nMAssay Description:In vitro degradation assay protocol for compounds 3-33: Panc02.13 cells were purchased from ATCC and cultured in RPMI-1640 (Gibco), supplemented with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM485830(US10946017, Compound 27)
Affinity DataKd:  130nMAssay Description:In vitro degradation assay protocol for compounds 3-33: Panc02.13 cells were purchased from ATCC and cultured in RPMI-1640 (Gibco), supplemented with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM485831(US10946017, Compound 28)
Affinity DataKd:  245nMAssay Description:In vitro degradation assay protocol for compounds 3-33: Panc02.13 cells were purchased from ATCC and cultured in RPMI-1640 (Gibco), supplemented with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM485844(US10946017, Compound 11DC50:)
Affinity DataKd:  4.60nMAssay Description:In vitro degradation assay protocol for compounds 3-33: Panc02.13 cells were purchased from ATCC and cultured in RPMI-1640 (Gibco), supplemented with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459897(CHEMBL4226319)
Affinity DataKd:  10nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459898(CHEMBL4227907)
Affinity DataKd:  4.60nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459900(CHEMBL4228346)
Affinity DataKd:  725nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459901(CHEMBL4226591)
Affinity DataKd:  13nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459902(CHEMBL4227342)
Affinity DataKd:  270nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459903(CHEMBL4226837)
Affinity DataKd:  275nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459904(CHEMBL4227097)
Affinity DataKd:  130nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459896(CHEMBL4226250)
Affinity DataKd:  245nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459908(CHEMBL4224757)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459909(CHEMBL4226693)
Affinity DataKd:  5.90nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459910(CHEMBL4228790)
Affinity DataKd:  104nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459911(CHEMBL4225766)
Affinity DataKd:  4nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50459912(CHEMBL4225995)
Affinity DataKd:  1.04E+3nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  9nMAssay Description:Binding affinity to recombinant human full length N-terminal GST-tagged TBK1 expressed in baculovirus expression system using CKtide as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  17nMAssay Description:Binding affinity to recombinant human full length N-terminal GST-tagged TBK1 expressed in baculovirus expression system using CKtide as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50509049(CHEMBL4440744)
Affinity DataEC50:  5.39E+4nMAssay Description:Induction of TBK1 in human PBMC assessed as increase in cGAMP secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM17051(N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl...)
Affinity DataKd:  158nMAssay Description:Binding affinity to TBK1 in human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataKd:  10nMAssay Description:Binding affinity to TBK1 in human HEK293/K562/placenta/HepG2 cell lysate mixture incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50111572(CHEMBL3605057)
Affinity DataKd:  79nMAssay Description:Binding affinity to TBK1 in human HEK293/K562/placenta/HepG2 cell lysate mixture incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataKd:  158nMAssay Description:Binding affinity to phosphorylated TBK1 in calyculin A stimulated human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50111572(CHEMBL3605057)
Affinity DataKd:  32nMAssay Description:Binding affinity to phosphorylated TBK1 in calyculin A stimulated human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM17051(N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl...)
Affinity DataKd:  40nMAssay Description:Binding affinity to phosphorylated TBK1 in calyculin A stimulated human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataKd:  20nMAssay Description:Binding affinity to TBK1 in human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM17051(N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl...)
Affinity DataKd:  20nMAssay Description:Binding affinity to TBK1 in human HEK293/K562/placenta/HepG2 cell lysate mixture incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50111572(CHEMBL3605057)
Affinity DataKd:  251nMAssay Description:Binding affinity to TBK1 in human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  2.46E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  12nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  9.30nMAssay Description:Binding affinity to TBK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  18nMAssay Description:Binding affinity to TBK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to TBK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  120nMAssay Description:Binding affinity to TBK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50326054(CHEMBL1240703)
Affinity DataKd:  150nMAssay Description:Binding affinity to TBK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to TBK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to TBK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  18nMAssay Description:Binding constant for TBK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  0.890nMAssay Description:Binding constant for TBK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  9.30nMAssay Description:Binding constant for TBK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  150nMAssay Description:Binding constant for TBK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas Operations

US Patent
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  23nMAssay Description:Binding constant for TBK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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