Compile Data Set for Download or QSAR
Report error Found 3549 for UniProtKB: Q9UQD0
LigandChemical structure of BindingDB Monomer ID 50240277BDBM50240277(CHEMBL4061793)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50240278BDBM50240278(CHEMBL4062780)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 793722BDBM793722((2R,3S,4S,5R)-N-(3-Carbamimidoyl-4-fluorophenyl)-3...)
Affinity DataIC50: 0.160nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 630996BDBM63996(US11802122, Example 73B | (S)-N-((R or S)-(3- chlo...)
Affinity DataIC50: 0.200nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621932BDBM621932(US20230312528, Example 73A | (S)-N-((R or S)-(3- c...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621933BDBM621933(US20230312528, Example 73B | (S)-N-((R or S)-(3- c...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 630994BDBM630994(US11802122, Example 73A | (S)-N-((R or S)-(3- chlo...)
Affinity DataIC50: 0.200nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 793716BDBM793716((2R,3S,4S,5R)-N-(2-Carbamimidoylpyridin-4-yl)-3-(3...)
Affinity DataIC50: 0.240nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 71381BDBM71381(US9694002, 440 | US9546164, 440)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 793727BDBM793727(4-((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 0.300nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 793713BDBM793713((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-N-(...)
Affinity DataIC50: 0.330nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 191035BDBM191035((S)-N-((R or S)-(4- chloro-3- (trifluoromethyl) ph...)
Affinity DataIC50: 0.400nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621911BDBM621911(US20230312528, Example 62B | (S)-N-((R or S)-(3- c...)
Affinity DataIC50: 0.400nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621910BDBM621910(US20230312528, Example 62A | US11802122, Example 6...)
Affinity DataIC50: 0.400nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 793728BDBM793728(4-((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 0.530nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621824BDBM621824(US20230312528, Example 17A | (S)-N-((R or S)-(4- c...)
Affinity DataIC50: 0.600nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 193024BDBM193024((S)-N-((R or S)-(4- chloro-3- methylphenyl)(4- chl...)
Affinity DataIC50: 0.600nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 190968BDBM190968((S)-N-((R)-(5-chloro-6-(trifluoromethyl)pyridin-2-...)
Affinity DataIC50: 0.600nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 630957BDBM630957(US11802122, Example 17A | (S)-N-((R or S)-(4- chlo...)
Affinity DataIC50: 0.600nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 372303BDBM372303(3-(3-chloro-2-fluoro-6-((2,2,7-trifluorobenzo[d][1...)
Affinity DataIC50: 0.640nMAssay Description:Reagents were purchased from Sigma (St. Louis, MO) except NaOH and KOH for acid-base titration. The final concentrations of the test compounds were a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 793718BDBM793718((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-N-(...)
Affinity DataIC50: 0.680nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621909BDBM621909(US20230312528, Example 61 | US11802122, Example 61...)
Affinity DataIC50: 0.700nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621909BDBM621909(US20230312528, Example 61 | US11802122, Example 61...)
Affinity DataIC50: 0.700nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 190988BDBM190988((S)-N-(bis(3- chloro-4- fluorophenyl) methyl)-2- o...)
Affinity DataIC50: 0.700nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 372315BDBM372315(3-(3,4-dichloro-2-fluoro-6-((2,2,7-trifluorobenzo[...)
Affinity DataIC50: 0.710nMAssay Description:Reagents were purchased from Sigma (St. Louis, MO) except NaOH and KOH for acid-base titration. The final concentrations of the test compounds were a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 71340BDBM71340(US9694002, 411 | US9546164, 411)
Affinity DataIC50: 0.800nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50118514BDBM50118514(US9481677, 38 | CHEMBL3617063)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of full length human Nav1.6 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 191008BDBM191008((S)-N-((R)-(3-chloro-4-fluorophenyl)(4-chloropheny...)
Affinity DataIC50: 0.900nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 793723BDBM793723((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-N-(...)
Affinity DataIC50: 0.930nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 372307BDBM372307(5-(3,4-Dichloro-2-fluoro-6-(4-(trifluoromethoxy)ph...)
Affinity DataIC50: 0.980nMAssay Description:Reagents were purchased from Sigma (St. Louis, MO) except NaOH and KOH for acid-base titration. The final concentrations of the test compounds were a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 374028BDBM374028(US10246453, Example 295 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 1nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 526223BDBM526223(4-((2-(azetidin-1-ylmethyl)benzyl)amino)-2,6-diflu...)
Affinity DataIC50: 1nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 526223BDBM526223(4-((2-(azetidin-1-ylmethyl)benzyl)amino)-2,6-diflu...)
Affinity DataIC50: 1nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 374028BDBM374028(US10246453, Example 295 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 1nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 526220BDBM526220(4-((2-(azetidin-1-ylmethyl)benzyl)amino)-3-chloro-...)
Affinity DataIC50: 1nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 374028BDBM374028(US10246453, Example 295 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 1nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 161329BDBM161329(US9163042, 1a | US9051270, 114 | US10087143, Compo...)
Affinity DataIC50: 1nMAssay Description:1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 374028BDBM374028(US10246453, Example 295 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 1nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 793715BDBM793715((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5...)
Affinity DataIC50: 1.01nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 793721BDBM793721((2R,3S,4S,5R)-N-(2-(2-Amino-2-oxoacetyl)pyridin-4-...)
Affinity DataIC50: 1.09nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621868BDBM621868(US20230312528, Example 38 | US11802122, Example 38...)
Affinity DataIC50: 1.10nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621822BDBM621822(US20230312528, Example 16A | (S)-N-((R or S)-(3- c...)
Affinity DataIC50: 1.10nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621746BDBM621746(US11802122, Example 7A | US20230312522, Compound 1...)
Affinity DataIC50: 1.10nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621746BDBM621746(US11802122, Example 7A | US20230312522, Compound 1...)
Affinity DataIC50: 1.10nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 621868BDBM621868(US20230312528, Example 38 | US11802122, Example 38...)
Affinity DataIC50: 1.10nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 630941BDBM630941(US11802122, Example 13A | (4S)-N-[((R or S)-5- chl...)
Affinity DataIC50: 1.10nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 190233BDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 621816BDBM621816(US20230312528, Example 13A | (4S)-N-[((R or S)-5- ...)
Affinity DataIC50: 1.10nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 630953BDBM630953(US11802122, Example 16A | US11802122, Example 16B ...)
Affinity DataIC50: 1.10nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 193040BDBM193040((S)-N-((R or S)-(3- chloro-4-(trifluoro- methoxy)p...)
Affinity DataIC50: 1.20nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2026
Entry Details
US Patent

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