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Hupehenols A-E, selective 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors from Viburnum hupehense.

Chinese Academy Of Sciences

Medicinal chemistry of inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1).

Astrazeneca

Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11ß-HSD1 inhibitors: potential impact in diabetes.

Chinese Academy Of Sciences

Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11ß-hydroxysteroid dehydrogenases.

Chinese Academy Of Sciences

Synthesis and evaluation of piperidine urea derivatives as efficacious 11ß-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice.

Chinese Academy Of Sciences

4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice.

Chinese Academy Of Sciences

Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.

Merck Research Laboratories

Substituted phenyl triazoles as selective inhibitors of 11 β-Hydroxysteroid Dehydrogenase Type 1.

Merck

Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome.

Merck Research Laboratories

4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.

Merck Research Laboratories

Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.

Abbott Laboratories

Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.

Abbott Laboratories

Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.

Abbott Laboratories

Discovery of orally active butyrolactam 11beta-HSD1 inhibitors.

Abbott Laboratories

Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.

Abbott Laboratories

Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.

Abbott Laboratories

Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11beta-HSD1: novel therapeutic agents for the treatment of metabolic syndrome.

Merck

Synthesis of selective 11?-HSD1 inhibitors based on dammarane scaffold.

Chinese Academy Of Sciences

Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11?-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.

Bristol-Myers Squibb

Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.

Academia Sinica