BDBM119812 US20240034730, Compound ASLAN003::US8691852, 20

SMILES COc1cccc(c1)-c1cc(F)c(Nc2ncccc2C(O)=O)c(F)c1

InChI Key InChIKey=OMPATGZMNFWVOH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 119812   

LigandPNGBDBM119812(US20240034730, Compound ASLAN003 | US8691852, 20)
Affinity DataIC50:  15nMpH: 8.0Assay Description:DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichlorophenol-indophenol). The substrate oxidation (...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM119812(US20240034730, Compound ASLAN003 | US8691852, 20)
Affinity DataIC50:  15nMAssay Description:Inhibition of Homo sapiens (human) dehydroorotate dihydrogenase using 2,6-dichlorophenol-indophenol as substrate after 10 min by spectrophotometric a...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM119812(US20240034730, Compound ASLAN003 | US8691852, 20)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM119812(US20240034730, Compound ASLAN003 | US8691852, 20)
Affinity DataIC50:  35nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM119812(US20240034730, Compound ASLAN003 | US8691852, 20)
Affinity DataIC50:  44nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM119812(US20240034730, Compound ASLAN003 | US8691852, 20)
Affinity DataIC50:  44nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed