BDBM142744 US8937095, 6
SMILES CCNC(=O)C#Cc1ccc2\C(=C(\Nc3ccc(CN(C)C)cc3)c3ccccc3)C(=O)Nc2c1
InChI Key InChIKey=FLBNLJLONKAPLR-DQSJHHFOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 142744
TargetAurora kinase B-B(Xenopus laevis (African clawed frog))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 3nMpH: 7.6Assay Description:The ATP-KM value of the complex is 61 uM. The kinase assays are run in the presence of 100 uM ATP using 10 uM of a substrate peptide. pAUB-IN847 was ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 25nMpH: 7.6Assay Description:The ATP-KM value of the complex is 61 uM. The kinase assays are run in the presence of 100 uM ATP using 10 uM of a substrate peptide. pAUB-IN847 was ...More data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by ChEMBL
University Of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human full-length His-tagged Aurora B expressed in baculovirus expression system using 5-FAM-LRRASLG-CONH2 as substrate pre...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by ChEMBL
University Of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 25nMAssay Description:Inhibition of human MEK1More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human MEK2More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of Xenopus laevis Aurora Kinase AMore data for this Ligand-Target Pair
TargetAurora kinase B-B(Xenopus laevis (African clawed frog))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 3nMAssay Description:Inhibition of Xenopus laevis Aurora Kinase BMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by ChEMBL
University Of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human Aurora AMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human Aurora CMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 25nMAssay Description:Inhibition of human MEK1More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human MEK2More data for this Ligand-Target Pair