BDBM15211 CHEMBL104264::H-89::H89::HT-89 (H-89)::N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide::N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide
SMILES Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1
InChI Key InChIKey=ZKZXNDJNWUTGDK-NSCUHMNNSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 43 hits for monomerid = 15211
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Nagoya University School Of Medicine
Nagoya University School Of Medicine
Affinity DataKi: 48nM ΔG°: -10.1kcal/moleT: 2°CAssay Description:Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit beta(RAT)
Temple University
Curated by PDSP Ki Database
Temple University
Curated by PDSP Ki Database
TargetRho-associated protein kinase 2(Rattus norvegicus (Rat))
Temple University
Curated by PDSP Ki Database
Temple University
Curated by PDSP Ki Database
Affinity DataKi: 480nM ΔG°: -8.76kcal/moleT: 2°CAssay Description:Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...More data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry
Curated by ChEMBL
Institute For Biochemistry
Curated by ChEMBL
Affinity DataKi: 2.83E+4nMAssay Description:Inhibitory constant against MLCKMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataKi: 2.83E+4nMAssay Description:Binding affinity at MLCKChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 2.83E+4nM ΔG°: -6.30kcal/moleT: 2°CAssay Description:Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataKi: 2.97E+4nMAssay Description:Inhibition of CaM-KKbetaChecked by AuthorMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit beta(Homo sapiens (Human))
Nagoya University School Of Medicine
Nagoya University School Of Medicine
Affinity DataKi: 2.97E+4nM ΔG°: -6.28kcal/moleT: 2°CAssay Description:Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...More data for this Ligand-Target Pair
Affinity DataKi: 3.17E+4nM ΔG°: -6.24kcal/moleT: 2°CAssay Description:Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...More data for this Ligand-Target Pair
Affinity DataKi: 3.83E+4nMAssay Description:Inhibition of casein kinase 1Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 3.83E+4nM ΔG°: -6.12kcal/moleT: 2°CAssay Description:Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...More data for this Ligand-Target Pair
Affinity DataKi: 1.37E+5nM ΔG°: -5.36kcal/moleT: 2°CAssay Description:Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...More data for this Ligand-Target Pair
TargetCasein kinase II subunit alpha (Homo sapiens (Human))
Institute For Biochemistry
Curated by ChEMBL
Institute For Biochemistry
Curated by ChEMBL
Affinity DataKi: 1.37E+5nMAssay Description:Inhibitory constant against bovine CK2More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human PKBalpha expressed in SF9 cellsMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of His-tagged human MSK1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of His-tagged human S6K1 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of GST-tagged PKB/Akt1 incubated for 5 mins before eNOS substrate and ATP addition measured after 30 mins by kinase assayMore data for this Ligand-Target Pair
TargetMO15-related protein kinase Pfmrk(Plasmodium falciparum)
Institute Of Research
Curated by ChEMBL
Institute Of Research
Curated by ChEMBL
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of Plasmodium falciparum PfmrkMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of Akt1 (unknown origin) using ATP/eNOS as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by fluo...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of AKT1 (unknown origin) using ATP/eNOS as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by fluorescen...More data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of ROCK2Checked by AuthorMore data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of PKBbeta recombinant by radiometric filter binding assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of GSK3-beta in human PC3M cells by ELISAMore data for this Ligand-Target Pair
Affinity DataKd: 24nMAssay Description:Displacement of fluorescent-ARC-1063 from His6-tagged recombinant human ROCK2 by luminescence intensity assayMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit gamma(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of PKA-mediated phosphorylation of kemptide at 100 uMMore data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Torrey Pines Institute For Molecular Studies
Curated by ChEMBL
Torrey Pines Institute For Molecular Studies
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of AKT3 by FRET based assayChecked by AuthorMore data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of AKT2 by FRET based assayChecked by AuthorMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of AKT1 by FRET based assayChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKd: 24nMAssay Description:Displacement of fluorescent-ARC-1063 from His6-tagged recombinant human ROCK2 by luminescence intensity assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Rattus norvegicus (Rat))
Temple University
Curated by PDSP Ki Database
Temple University
Curated by PDSP Ki Database
Affinity DataIC50: 270nMAssay Description:Inhibition of rat ROCK2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assays were carried out using HTScan® PKB/Akt1 Kinase Assay kit (Cell Signaling Technology). Active recombinant Akt1 kinase (GST fusi...More data for this Ligand-Target Pair
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Torrey Pines Institute For Molecular Studies
Curated by ChEMBL
Torrey Pines Institute For Molecular Studies
Curated by ChEMBL
Affinity DataIC50: 662nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
University Of Tartu
University Of Tartu
Affinity DataIC50: 100nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
Affinity DataKd: 31nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
University Of Tartu
University Of Tartu
Affinity DataKd: 23nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics
Uk Centre For Cancer Therapeutics
Affinity DataIC50: 73nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit gamma(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 590nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Uk Centre For Cancer Therapeutics
Uk Centre For Cancer Therapeutics
Affinity DataIC50: 73nMpH: 7.2 T: 2°CAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair