BDBM172718 US11802108, Compound CSA::US9090657, Cyclosporine A, 1
SMILES CCC1NC(=O)C(C(O)C(C)C\C=C\C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InChI Key InChIKey=PMATZTZNYRCHOR-IMVLJIQESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 172718
Affinity DataIC50: 9.70nMAssay Description:The PPlase activity of recombinant CypA or D, produced by thrombin cleavage of GST-CypA or D, was determined by following the rate of hydrolysis of N...More data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Neurovive Pharmaceutical
US Patent
Neurovive Pharmaceutical
US Patent
Affinity DataIC50: 850nMpH: 7.3 T: 2°CAssay Description:To assess the inhibition of the OAT1B1 and OAT1B3 uptake transporters, an in vitro uptake transporter assay from Solvo Biotechnology Inc. was used. U...More data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Neurovive Pharmaceutical
US Patent
Neurovive Pharmaceutical
US Patent
Affinity DataIC50: 130nMpH: 7.3 T: 2°CAssay Description:To assess the inhibition of the OAT1B1 and OAT1B3 uptake transporters, an in vitro uptake transporter assay from Solvo Biotechnology Inc. was used. U...More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Neurovive Pharmaceutical
US Patent
Neurovive Pharmaceutical
US Patent
Affinity DataIC50: 4.10E+3nMT: 2°CAssay Description:To assess the inhibition of the MRP2, MRP3 and BSEP efflux transporters, an in vitro vesicular transporter assay from Solvo Biotechnology Inc. was us...More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Neurovive Pharmaceutical
US Patent
Neurovive Pharmaceutical
US Patent
Affinity DataIC50: 3.10E+3nMT: 2°CAssay Description:To assess the inhibition of the MRP2, MRP3 and BSEP efflux transporters, an in vitro vesicular transporter assay from Solvo Biotechnology Inc. was us...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase B(Homo sapiens (Human))
The University Court Of The University Of Edinburgh
US Patent
The University Court Of The University Of Edinburgh
US Patent
Affinity DataKd: 19nMAssay Description:Pure His-cyclophilins were immobilized and covalently stabilized on the NTA sensor chip according to the protocol described in Thermo-kinetic analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 460nMT: 2°CAssay Description:To assess the inhibition of the MRP2, MRP3 and BSEP efflux transporters, an in vitro vesicular transporter assay from Solvo Biotechnology Inc. was us...More data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:All ITC experiments for the ester series compounds were carried out at 25° C. on a MicroCal Auto iTC200 (GE Healthcare) instrument. The buffer used i...More data for this Ligand-Target Pair
Affinity DataKd: 24nMAssay Description:Pure His-cyclophilins were immobilized and covalently stabilized on the NTA sensor chip according to the protocol described in Thermo-kinetic analysi...More data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Pure His-cyclophilins were immobilized and covalently stabilized on the NTA sensor chip according to the protocol described in Thermo-kinetic analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 730nMpH: 7.4 T: 2°CAssay Description:To assess the inhibition of the P-glycoprotein (Pgp/MDR1) transporter, an in vitro ATPase assay from Cyprotex was used. MDR1MDCK cells obtained from ...More data for this Ligand-Target Pair