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Found 4 Enz. Inhib. hit(s) with Target = 'Peptidyl-prolyl cis-trans isomerase A' and Ligand = 'BDBM172718'
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Neurovive Pharmaceutical

US Patent
LigandPNGBDBM172718(US11802108, Compound CSA | US9090657, Cyclosporine...)
Affinity DataIC50:  9.70nMAssay Description:The PPlase activity of recombinant CypA or D, produced by thrombin cleavage of GST-CypA or D, was determined by following the rate of hydrolysis of N...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Neurovive Pharmaceutical

US Patent
LigandPNGBDBM172718(US11802108, Compound CSA | US9090657, Cyclosporine...)
Affinity DataKd:  24nMAssay Description:Pure His-cyclophilins were immobilized and covalently stabilized on the NTA sensor chip according to the protocol described in Thermo-kinetic analysi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Neurovive Pharmaceutical

US Patent
LigandPNGBDBM172718(US11802108, Compound CSA | US9090657, Cyclosporine...)
Affinity DataKd:  10nMAssay Description:Pure His-cyclophilins were immobilized and covalently stabilized on the NTA sensor chip according to the protocol described in Thermo-kinetic analysi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Neurovive Pharmaceutical

US Patent
LigandPNGBDBM172718(US11802108, Compound CSA | US9090657, Cyclosporine...)
Affinity DataKd:  11nMAssay Description:All ITC experiments for the ester series compounds were carried out at 25° C. on a MicroCal Auto iTC200 (GE Healthcare) instrument. The buffer used i...More data for this Ligand-Target Pair
In DepthDetails US Patent