BDBM18493 3-(2,4-diaminopyrimidin-5-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-yn-1-ol::JMC517532 Compound 6::Propargyl-linked, 3::TMP derivative with propargyl-based linker, 24

SMILES: COc1cc(cc(OC)c1OC)C(O)C#Cc1cnc(N)nc1N

InChI Key: InChIKey=CHQKJSKTNSOLMY-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 18493   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium parvum)	BDBM18493 (Propargyl-linked, 3 | JMC517532 Compound 6 | 3-(2,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.94E+5	n/a	n/a	n/a	n/a	7.0	25
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Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18493 (Propargyl-linked, 3 | JMC517532 Compound 6 | 3-(2,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.79E+4	n/a	n/a	n/a	n/a	7.0	25
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Dihydrofolate reductase (Bacillus anthracis)	BDBM18493 (Propargyl-linked, 3 | JMC517532 Compound 6 | 3-(2,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.12E+4	n/a	n/a	n/a	n/a	7.0	25
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Dihydrofolate reductase (Human)	BDBM18493 (Propargyl-linked, 3 | JMC517532 Compound 6 | 3-(2,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.43E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Human)	BDBM18493 (Propargyl-linked, 3 | JMC517532 Compound 6 | 3-(2,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.43E+4	n/a	n/a	n/a	n/a	n/a	25
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Dihydrofolate reductase (Yeast)	BDBM18493 (Propargyl-linked, 3 | JMC517532 Compound 6 | 3-(2,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	25
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Dihydrofolate reductase (Human)	BDBM18493 (Propargyl-linked, 3 | JMC517532 Compound 6 | 3-(2,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.43E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Yeast)	BDBM18493 (Propargyl-linked, 3 | JMC517532 Compound 6 | 3-(2,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
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