BDBM186184 US9163013, 1

SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CCc4ccc(O)cc4)CC3)c2c1

InChI Key InChIKey=SOKOQHNUYVVYND-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 186184   

TargetGlycogen synthase kinase-3 beta(Human)
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.

US Patent
LigandPNGBDBM186184(US9163013, 1)
Affinity DataIC50: 350nMT: 2°CAssay Description:Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2016
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.

US Patent
LigandPNGBDBM186184(US9163013, 1)
Affinity DataIC50: 350nMAssay Description:Inhibition of Glycogen synthase kinase-3 beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 16(Human)
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.

US Patent
LigandPNGBDBM186184(US9163013, 1)
Affinity DataIC50: 1.50E+3nMT: 2°CAssay Description:Compound 1 was also assayed to determine the IC50 values for three different kinases (PCTAIRE1, DYRK1a, and CDK2) in comparison to Gsk3beta. The assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2016
Entry Details
US Patent

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.

US Patent
LigandPNGBDBM186184(US9163013, 1)
Affinity DataIC50: 2.90E+3nMT: 2°CAssay Description:Compound 1 was also assayed to determine the IC50 values for three different kinases (PCTAIRE1, DYRK1a, and CDK2) in comparison to Gsk3beta. The assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2016
Entry Details
US Patent

TargetCyclin-dependent kinase 2(Human)
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.

US Patent
LigandPNGBDBM186184(US9163013, 1)
Affinity DataIC50: 3.60E+4nMT: 2°CAssay Description:Compound 1 was also assayed to determine the IC50 values for three different kinases (PCTAIRE1, DYRK1a, and CDK2) in comparison to Gsk3beta. The assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2016
Entry Details
US Patent