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BDBM292814 US10106501, Example EW

SMILES: Cc1cn(Cc2c(Cl)ccc(C(=O)N3CCC(CC(O)=O)CC3)c2Cl)c2c(C)cc(nc12)C(F)(F)F

InChI Key: InChIKey=KPICWCQMJHRIQZ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 292814   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM292814
PNG
(US10106501, Example EW)
Show SMILES Cc1cn(Cc2c(Cl)ccc(C(=O)N3CCC(CC(O)=O)CC3)c2Cl)c2c(C)cc(nc12)C(F)(F)F
Show InChI InChI=1S/C25H24Cl2F3N3O3/c1-13-9-19(25(28,29)30)31-22-14(2)11-33(23(13)22)12-17-18(26)4-3-16(21(17)27)24(36)32-7-5-15(6-8-32)10-20(34)35/h3-4,9,11,15H,5-8,10,12H2,1-2H3,(H,34,35)
PDB

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PC cid
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US Patent
n/an/a 300n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...


US Patent US10106501 (2018)


BindingDB Entry DOI: 10.7270/Q2G44SBV
More data for this
Ligand-Target Pair