BDBM29388 Exanta::Melagatran::US11584714, Compound 999
SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCN2C(=O)[C@H](NCC(O)=O)C2CCCCC2)cc1
InChI Key InChIKey=DKWNMCUOEDMMIN-PKOBYXMFSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 29388
Affinity DataKi: 1.20nMAssay Description:Binding affinity against human thrombinMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 2nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <500nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
Affinity DataKi: 700nMAssay Description:Inhibition of plasmin (unknown origin)More data for this Ligand-Target Pair
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Philipps University Marburg
Curated by ChEMBL
Philipps University Marburg
Curated by ChEMBL
Affinity DataKi: 900nMAssay Description:Inhibition of tissue-type plasminogen activator (unknown origin)More data for this Ligand-Target Pair
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Philipps University Marburg
Curated by ChEMBL
Philipps University Marburg
Curated by ChEMBL
Affinity DataKi: 1.51E+3nMAssay Description:Inhibition of human t-PAMore data for this Ligand-Target Pair
Affinity DataKi: 1.80E+3nMAssay Description:Inhibition of human plasminMore data for this Ligand-Target Pair
Affinity DataKi: 3.68E+3nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Philipps University Marburg
Curated by ChEMBL
Philipps University Marburg
Curated by ChEMBL
Affinity DataKi: 6.30E+3nMAssay Description:Inhibition of urokinase-type plasminogen activator (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 69.2nMAssay Description:Inhibition of thrombin by chromogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.06E+3nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human coagulation factor 11a using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human coagulation factor 10a using S-2765 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:In vitro inhibitory concentration of compound against human thrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:In vitro inhibitory activity against thrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:In vitro inhibitory activity against trypsinMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:The thrombin inhibitor potency (IC50) was measured with a chromogenic substrate method in a robotic microplate processor, using 96-well, half-volume ...More data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of F10aMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair