BDBM47032 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylsulfinyl]-1H-benzimidazole::2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methylsulfinyl]-1H-benzimidazole::2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole::2-[[3-methyl-4-[2,2,2-tris(fluoranyl)ethoxy]pyridin-2-yl]methylsulfinyl]-1H-benzimidazole::LANSOPRAZOLE::MLS-0003247.0001::cid_3883

SMILES Cc1c(OCC(F)(F)F)ccnc1CS(=O)c1nc2ccccc2[nH]1

InChI Key InChIKey=MJIHNNLFOKEZEW-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 47032   

TargetMicrotubule-associated protein tau(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM47032(2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to heparin induced human Tau 441 at 50 pM to 500 nM after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Institute of Clinical Pharmacology

Curated by ChEMBL
LigandPNGBDBM47032(2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl...)
Affinity DataIC50:  6.28E+4nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Mus musculus)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM47032(2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl...)
Affinity DataIC50:  9.40E+4nMAssay Description:Inhibition of mouse Ido1 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 2(Mus musculus)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM47032(2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine/phosphocholine phosphatase(Homo sapiens (Human))
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM47032(2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl...)
Affinity DataIC50:  434nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay