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BDBM50002133 (+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydroxyethylamino)propyl)phenoxy)acetic acid::(4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxy)-acetic acid::(4-{2-[(R)-2-((R)-3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxy)-acetic acid::(4-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxy)-acetic acid::(BRL 37,344)(4-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxy)-acetic acid::(R*, R*) (4-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxy)-acetic acid::2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydroxyethylamino)propyl)phenoxy)acetic acid::BRL-37344::CHEMBL284782
SMILES: C[C@H](Cc1ccc(OCC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1
InChI Key: InChIKey=ZGGNJJJYUVRADP-ACJLOTCBSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cells | Bioorg Med Chem Lett 7: 1583-1588 (1997) Article DOI: 10.1016/S0960-894X(97)00266-7 BindingDB Entry DOI: 10.7270/Q24749VQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Binding affinity against CHO cells transfected with human beta-3 adrenergic receptor in the presence of [125I]iodocyanopindolol | Bioorg Med Chem Lett 11: 3035-9 (2001) Article DOI: 10.1016/s0960-894x(01)00628-x BindingDB Entry DOI: 10.7270/Q2MS3T97 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 960 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cells | Bioorg Med Chem Lett 7: 1583-1588 (1997) Article DOI: 10.1016/S0960-894X(97)00266-7 BindingDB Entry DOI: 10.7270/Q24749VQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor and beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 960 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic recepto (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 1.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cells | Bioorg Med Chem Lett 7: 1583-1588 (1997) Article DOI: 10.1016/S0960-894X(97)00266-7 BindingDB Entry DOI: 10.7270/Q24749VQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Milano Curated by ChEMBL | Assay Description Displacement of [125I]CYP from human adrenergic beta 2 receptor transfected in CHO cells in presence of 100 uM GTP | Bioorg Med Chem 15: 2533-43 (2007) Article DOI: 10.1016/j.bmc.2007.01.056 BindingDB Entry DOI: 10.7270/Q2765F04 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic recepto (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 1.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 450 | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Compound was evaluated for agonistic activity in human Beta-3 adrenergic receptor assay; partial weak agonist | Bioorg Med Chem Lett 8: 3087-92 (1999) Article DOI: 10.1016/s0960-894x(98)00571-x BindingDB Entry DOI: 10.7270/Q25H7FF6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic recepto (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR | Bioorg Med Chem Lett 13: 1301-5 (2003) Article DOI: 10.1016/s0960-894x(03)00073-8 BindingDB Entry DOI: 10.7270/Q25B01TS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR | Bioorg Med Chem Lett 13: 1301-5 (2003) Article DOI: 10.1016/s0960-894x(03)00073-8 BindingDB Entry DOI: 10.7270/Q25B01TS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor and beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0950 | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Agonistic activity against human Beta-3 adrenergic receptor as cAMP accumulation in CHO cells expressing beta3-AR | Bioorg Med Chem Lett 13: 1301-5 (2003) Article DOI: 10.1016/s0960-894x(03)00073-8 BindingDB Entry DOI: 10.7270/Q25B01TS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd Curated by ChEMBL | Assay Description Concentration required to effect a 50% relaxation of ferret detrusor basal tone | J Med Chem 46: 105-12 (2002) Article DOI: 10.1021/jm020177z BindingDB Entry DOI: 10.7270/Q2BP03J1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor beta (Rattus norvegicus) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd Curated by ChEMBL | Assay Description Inhibition of spontaneous contractions in isolated rat uterus | J Med Chem 46: 105-12 (2002) Article DOI: 10.1021/jm020177z BindingDB Entry DOI: 10.7270/Q2BP03J1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor and beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 450 | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Agonism against Beta-3 adrenergic receptor | Bioorg Med Chem Lett 8: 3087-92 (1999) Article DOI: 10.1016/s0960-894x(98)00571-x BindingDB Entry DOI: 10.7270/Q25H7FF6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Canis familiaris) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd Curated by ChEMBL | Assay Description Agonistic activity for Beta-2 adrenergic receptor was assessed by it's inhibitory effect on spontaneous contractions in isolated rat uterus | J Med Chem 46: 105-12 (2002) Article DOI: 10.1021/jm020177z BindingDB Entry DOI: 10.7270/Q2BP03J1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a |
Universit£ di Bari Curated by ChEMBL | Assay Description Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP levels by DELFIA method | Bioorg Med Chem 16: 2473-88 (2008) Article DOI: 10.1016/j.bmc.2007.11.060 BindingDB Entry DOI: 10.7270/Q2TD9Z7B | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor beta (Rattus norvegicus) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.19 | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd Curated by ChEMBL | Assay Description Agonistic activity towards beta-3 adrenoceptor. Mean concentration required to produce 50% relaxation of detrusor before the addition in the ferret d... | J Med Chem 44: 1436-45 (2001) Article DOI: 10.1021/jm000455z BindingDB Entry DOI: 10.7270/Q2Q52QVH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor beta (Rattus norvegicus) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.12 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd Curated by ChEMBL | Assay Description Agonistic activity towards beta-2 adrenoceptor. Mean concentration required to produce 50% inhibition of uterine contraction | J Med Chem 44: 1436-45 (2001) Article DOI: 10.1021/jm000455z BindingDB Entry DOI: 10.7270/Q2Q52QVH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor and beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | n/a | 680 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cells | Bioorg Med Chem Lett 7: 1583-1588 (1997) Article DOI: 10.1016/S0960-894X(97)00266-7 BindingDB Entry DOI: 10.7270/Q24749VQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor alpha-1 (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a |
American Cyanamid Company Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards Beta-1 adrenergic receptor in rat heart membrane by displacing [125I]- iodocyanopindolol | J Med Chem 35: 3081-4 (1992) Article DOI: 10.1021/jm00094a025 BindingDB Entry DOI: 10.7270/Q2PR7TWN | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor beta (Rattus norvegicus (Rat)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
American Cyanamid Company Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards Beta-1 adrenergic receptor in rat heart membrane by displacing [125I]- iodocyanopindolol | J Med Chem 35: 3081-4 (1992) Article DOI: 10.1021/jm00094a025 BindingDB Entry DOI: 10.7270/Q2PR7TWN | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic recepto (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Agonist activity at Homo sapiens (human) beta1 adrenoreceptor | Med Chem Res 19: 1121-1140 (2010) BindingDB Entry DOI: 10.7270/Q2057JTC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 290 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Agonist activity at Homo sapiens (human) beta2 adrenoreceptor | Med Chem Res 19: 1121-1140 (2010) BindingDB Entry DOI: 10.7270/Q2057JTC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic recepto (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Beta-1 adrenergic receptor binding affinity in CHO cells expressing cloned human receptor in the presence of 125 I-iodocyanopindolol | Bioorg Med Chem Lett 8: 3087-92 (1999) Article DOI: 10.1016/s0960-894x(98)00571-x BindingDB Entry DOI: 10.7270/Q25H7FF6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a |
Universit£ di Bari Curated by ChEMBL | Assay Description Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as [3H]cAMP levels by radiolabeled ligand based assay | Bioorg Med Chem 16: 2473-88 (2008) Article DOI: 10.1016/j.bmc.2007.11.060 BindingDB Entry DOI: 10.7270/Q2TD9Z7B | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 290 | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Agonistic activity against human Beta-2 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR | Bioorg Med Chem Lett 13: 1301-5 (2003) Article DOI: 10.1016/s0960-894x(03)00073-8 BindingDB Entry DOI: 10.7270/Q25B01TS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor beta (Rattus norvegicus (Rat)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
American Cyanamid Company Curated by ChEMBL | Assay Description Compound was evaluated in vitro for beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucos... | J Med Chem 35: 3081-4 (1992) Article DOI: 10.1021/jm00094a025 BindingDB Entry DOI: 10.7270/Q2PR7TWN | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor beta (Rattus norvegicus) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
American Cyanamid Company Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity towards Beta-2 adrenergic receptor in rat soleus membrane by displacing (-)-isoproterenol (50 microM) | J Med Chem 35: 3081-4 (1992) Article DOI: 10.1021/jm00094a025 BindingDB Entry DOI: 10.7270/Q2PR7TWN | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor beta (Rattus norvegicus) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 8.40 | n/a | n/a | n/a | n/a |
American Cyanamid Company Curated by ChEMBL | Assay Description Compound was evaluated in vitro for beta-adrenergic activity against beta-3 adrenergic receptor in rat epididymal fat pads by stimulation of glycerol... | J Med Chem 35: 3081-4 (1992) Article DOI: 10.1021/jm00094a025 BindingDB Entry DOI: 10.7270/Q2PR7TWN | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Beta-2 adrenergic receptor binding affinity in CHO cells expressing cloned human receptor in the presence of 125 I-iodocyanopindolol | Bioorg Med Chem Lett 8: 3087-92 (1999) Article DOI: 10.1016/s0960-894x(98)00571-x BindingDB Entry DOI: 10.7270/Q25H7FF6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor and beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Agonist activity at Homo sapiens (human) beta3 adrenoreceptor | Med Chem Res 19: 1121-1140 (2010) BindingDB Entry DOI: 10.7270/Q2057JTC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | n/a | 680 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its ability to stimulate adenylyl cyclase activity in CHO-beta-3 adrenergic receptor cell membrane. | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
