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BDBM50006798 2-[3-(Quinolin-2-ylmethoxy)-phenylamino]-benzoic acid::2-[3-(Quinolin-2-ylmethoxy)-phenylamino]-benzoic acid(SR2640)::CHEMBL18132::cid_128355

SMILES: OC(=O)c1ccccc1Nc1cccc(OCc2ccc3ccccc3n2)c1

InChI Key: InChIKey=LMPZHLXYBWGGNT-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50006798   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homo sapiens huntingtin (HTT), mRNA


(Homo sapiens (Human))
BDBM50006798
PNG
(2-[3-(Quinolin-2-ylmethoxy)-phenylamino]-benzoic a...)
Show SMILES OC(=O)c1ccccc1Nc1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C23H18N2O3/c26-23(27)20-9-2-4-11-22(20)24-17-7-5-8-19(14-17)28-15-18-13-12-16-6-1-3-10-21(16)25-18/h1-14,24H,15H2,(H,26,27)
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n/an/a 3.52E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2N58K09
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50006798
PNG
(2-[3-(Quinolin-2-ylmethoxy)-phenylamino]-benzoic a...)
Show SMILES OC(=O)c1ccccc1Nc1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C23H18N2O3/c26-23(27)20-9-2-4-11-22(20)24-17-7-5-8-19(14-17)28-15-18-13-12-16-6-1-3-10-21(16)25-18/h1-14,24H,15H2,(H,26,27)
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n/an/a 23n/an/an/an/an/an/a



ICI Pharmaceuticals Group

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-LTD4 from Cysteinyl leukotriene D4 receptor in guinea pig lung membranes


J Med Chem 34: 1235-42 (1991)


Article DOI: 10.1021/jm00108a001
BindingDB Entry DOI: 10.7270/Q2K936HB
More data for this
Ligand-Target Pair
Cyclooxygenase


(RAT)
BDBM50006798
PNG
(2-[3-(Quinolin-2-ylmethoxy)-phenylamino]-benzoic a...)
Show SMILES OC(=O)c1ccccc1Nc1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C23H18N2O3/c26-23(27)20-9-2-4-11-22(20)24-17-7-5-8-19(14-17)28-15-18-13-12-16-6-1-3-10-21(16)25-18/h1-14,24H,15H2,(H,26,27)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory activity against Prostaglandin G/H synthase in rat polymorphonuclear leukocytes[PMNS]


J Med Chem 35: 2501-24 (1992)


Article DOI: 10.1021/jm00092a001
BindingDB Entry DOI: 10.7270/Q23B60R4
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50006798
PNG
(2-[3-(Quinolin-2-ylmethoxy)-phenylamino]-benzoic a...)
Show SMILES OC(=O)c1ccccc1Nc1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C23H18N2O3/c26-23(27)20-9-2-4-11-22(20)24-17-7-5-8-19(14-17)28-15-18-13-12-16-6-1-3-10-21(16)25-18/h1-14,24H,15H2,(H,26,27)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory activity against 5-lipoxygenase in rat polymorphonuclear leukocytes[PMNS]


J Med Chem 35: 2501-24 (1992)


Article DOI: 10.1021/jm00092a001
BindingDB Entry DOI: 10.7270/Q23B60R4
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50006798
PNG
(2-[3-(Quinolin-2-ylmethoxy)-phenylamino]-benzoic a...)
Show SMILES OC(=O)c1ccccc1Nc1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C23H18N2O3/c26-23(27)20-9-2-4-11-22(20)24-17-7-5-8-19(14-17)28-15-18-13-12-16-6-1-3-10-21(16)25-18/h1-14,24H,15H2,(H,26,27)
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n/an/a 23n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against LTD4 (leukotriene).


J Med Chem 39: 2629-54 (1996)


Article DOI: 10.1021/jm960088k
BindingDB Entry DOI: 10.7270/Q21J9BFT
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50006798
PNG
(2-[3-(Quinolin-2-ylmethoxy)-phenylamino]-benzoic a...)
Show SMILES OC(=O)c1ccccc1Nc1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C23H18N2O3/c26-23(27)20-9-2-4-11-22(20)24-17-7-5-8-19(14-17)28-15-18-13-12-16-6-1-3-10-21(16)25-18/h1-14,24H,15H2,(H,26,27)
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n/an/a 23n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against binding of Cysteinyl leukotriene D4 receptor from guinea pig lung using [3H]-LTD4


J Med Chem 33: 1194-200 (1990)


Article DOI: 10.1021/jm00166a017
BindingDB Entry DOI: 10.7270/Q2PK0F4V
More data for this
Ligand-Target Pair