BDBM50008072 (+)-pilocarpine::(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one::(3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone::(3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone::CHEMBL550::ISOPTO CARPINE::PILOCARPINE::PILOCARPINE HYDROCHLORIDE

SMILES CC[C@H]1[C@@H](Cc2cncn2C)COC1=O

InChI Key InChIKey=QCHFTSOMWOSFHM-WPRPVWTQSA-N

Data  18 KI  7 IC50  4 Kd  5 EC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50008072   

TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  83nMAssay Description:Inhibition of [3H]OXO-M binding against muscarinic acetylcholine receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  1.01E+3nMAssay Description:Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  1.11E+3nMAssay Description:The compound was tested for inhibition of [3H]NMS binding against muscarinic acetylcholine receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A13(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  1.40E+3nMAssay Description:Competitive inhibition of CYP2A13 (unknown origin)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor DM1(Drosophila melanogaster)
University Of California

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  2.80E+3nMAssay Description:Displacement of [3H]AF-DX 384 from Drosophila melanogaster mAChR by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor DM1(Drosophila melanogaster)
University Of California

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  2.98E+3nMAssay Description:Displacement of [3H]QNB from Drosophila melanogaster mAChR by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  3.00E+3nMAssay Description:Mixed inhibition of CYP2A6 (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  3.10E+3nMAssay Description:Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M1, using [3H]- pirenzepine, a radioligand displacement assay in ra...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  3.67E+3nMAssay Description:Binding affinity against muscarinic acetylcholine receptor from rat brain crude membrane, using [3H]-NMS (N-Methylscopolamine) as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  6.61E+3nMAssay Description:Binding affinity to human cloned muscarinic M1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  7.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  7.94E+3nMAssay Description:Binding affinity to muscarinic M1 acetylcholine receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  9.80E+3nMAssay Description:Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement as...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  9.93E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  1.02E+4nMAssay Description:Binding affinity to human cloned muscarinic M5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKi:  1.20E+4nMAssay Description:Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataEC50:  8.79E+3nMAssay Description:Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataEC50:  6.30E+4nMAssay Description:Stimulation of cAMP in CHO cells expressing human m2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataIC50:  80nMAssay Description:Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataIC50:  68nMAssay Description:Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataIC50:  7.60E+3nMAssay Description:Binding affinity at 5-hydroxytryptamine 3 receptor in rat posterior cortex by [3H]-BRL 43694 displacement.More data for this Ligand-Target Pair
In DepthDetails
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of [3H]-(R)-QNB binding to muscarinic receptors of rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataIC50:  4.43E+3nMAssay Description:Compound was evaluated for the displacement of the muscarinic QNB in a genetically transformed rat cell line (m1c2) transfected with cloned m1 recept...More data for this Ligand-Target Pair
In DepthDetails Article
TargetCytochrome P450 2A13(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to CYP2A13 (unknown origin) assessed as type 2 interaction as increase in absorbance 431 to 432 nm and decrease in 406 to 412 nmMore data for this Ligand-Target Pair
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataIC50:  8.80E+3nMAssay Description:Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCytochrome P450 2A6(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity to CYP2A6 (unknown origin) assessed as type 2 interaction as increase in absorbance 431 to 432 nm and decrease in 406 to 412 nmMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKd:  2.69E+3nMAssay Description:Binding affinity to muscarinic M1 acetylcholine receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataKd:  2.69E+3nMAssay Description:Displacement of [3H]NMS from human muscarinic M1 acetylcholine receptor expressed in CHO cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataEC50:  832nMAssay Description:Partial agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as increase in IP1 accumulation incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataIC50:  960nMAssay Description:Ability to displace [3H]-pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Mus musculus)
The University Of Toledo

Curated by ChEMBL
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataEC50:  6.90E+3nMAssay Description:Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50008072((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed