BDBM50015214 6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-methylbutyl)amine::6-chloro-N-(5-(diethylamino)pentan-2-yl)-2-methoxyacridin-9-amine::CHEMBL7568::N'-(6-chloro-2-methoxy-acridin-9-yl)-N,N-diethyl-pentane-1,4-diamine::N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine::N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine (Mepacrine)::N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine ; (mepacrine)::N-(4-Hydroxy-phenyl)-acetamide::cid_237::quinacrine

SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12

InChI Key InChIKey=GPKJTRJOBQGKQK-UHFFFAOYSA-N

Data  3 KI  26 IC50  1 Kd  3 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50015214   

TargetRiboflavin-binding protein(Gallus gallus)
Calvin College

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataKi:  6.70E+3nMAssay Description:Competitive inhibition of chicken riboflavin binding protein by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Heidelberg University

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataKi:  1.90E+4nMAssay Description:The competitive inhibitory activity against trypanothione reductase was evaluated from Lineweaver Burk plotsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Heidelberg University

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Heidelberg University

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  1.33E+5nMAssay Description:Inhibitory concentration of the compound against trypanothione reductase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory concentration of the compound against human Glutathione reductase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic phospholipase A2 2(Naja naja)
Universitat De Val£Ncia

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  2.16E+6nMAssay Description:Inhibition of snake venom phospholipase A2 assessed as oxygen consumption for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde oxidase 1(Oryctolagus cuniculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of rabbit aldehyde oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde oxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human aldehyde oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of Equine serum BChE using butyrylthiocoline iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRiboflavin-binding protein(Gallus gallus)
Calvin College

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataKd:  264nMpH: 7.4Assay Description:Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 7.4 in phosphate buffer by isothermal titration calori...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, major isoenzyme(Sus scrofa (pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  1.00E+5nMAssay Description:Tested for its inhibitory activity against Phospholipase A2 (PLA2)More data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  1.30E+5nMAssay Description:Tested for its inhibitory activity against 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  1.30E+5nMAssay Description:Inhibition of rat basophilic leukemia cell 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPhospholipase A2(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibitory activity against polymorphonuclear cell phospholipase-A2 in ratMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPhospholipase A2, membrane associated(Rattus norvegicus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  3.20E+8nMAssay Description:In vitro inhibition of rat secretory Phospholipase A2 (group II).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  7.60E+7nMAssay Description:In vitro inhibition of human recombinant secretory Phospholipase A2 (group II).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMajor prion protein(Homo sapiens (Human))
Institut F£R Molekularbiologie Und Biophysik

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataEC50:  300nMAssay Description:Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  3.26E+4nMAssay Description:Tested for its inhibitory activity against PGS (prostaglandin synthetase).More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Strasbourg 1 University

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataEC50:  1.44E+4nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: 0.25 uM) in MDR-CEM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic phospholipase A2 2(Naja naja)
Universitat De Val£Ncia

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  2.15E+6nMAssay Description:Inhibition of Naja Naja PLA2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Kyoto Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  2.92E+5nMAssay Description:Inhibition of Tween 20-induced beta-hematin formation by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(Ovis aries (Sheep))
TBA

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  1.30E+5nMAssay Description:Inhibition of ovine seminal vesicle prostaglandin synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  1.01E+5nMAssay Description:Inhibition of human placental Monoamine oxidase A (competitive inhibition was observed)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50: >5.00E+4nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase(Homo sapiens)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of cGAS (unknown origin) incubated for 1 hr by Typhoon imaging system analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclic GMP-AMP synthase(Homo sapiens)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of cGAS in human THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrypanothione reductase(Leishmania infantum)
Universidad De Alcal£

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of recombinant His-tagged Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli BL21 (DE3) using TS2 and NADPH as...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA-directed RNA polymerase subunit beta'(Escherichia coli K-12)
TBA

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of Escherichia coli DNA-primed RNA polymerase activity using [8-14C]ATP by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMajor prion protein(Mus musculus)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  95nMAssay Description:Synergistic anti-prion activity of mouse ScN2a cells infected with RML prion assessed as reduction of RML accumulation by isobologram analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Southern Research Institute

Curated by PubChem BioAssay
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataIC50:  1.99E+4nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Southern Research Institute

Curated by PubChem BioAssay
LigandPNGBDBM50015214(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Affinity DataEC50: >5.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay