BDBM50017550 CHEMBL76399::N*6*-Propyl-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine::N*6*-Propyl-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine (Pramipexole, PPX)::Pramipexole

SMILES CCCNC1CCc2nc(N)sc2C1

InChI Key InChIKey=FASDKYOPVNHBLU-UHFFFAOYSA-N

Data  23 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50017550   

TargetD(3) dopamine receptor(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi:  10nMAssay Description:Tested for the ability to displace [125I]iodosulpiride from human cloned Dopamine receptor D3, expressed in CHO cellsMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi:  10.5nMMore data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi:  129nMMore data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi:  631nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi:  692nMMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi:  955nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi:  1.66E+3nMMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi:  1.70E+3nMMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi:  1.70E+3nMMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi:  5.50E+3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi:  8.32E+3nMMore data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(BOVINE)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against dopamine receptor D2 in calf corpus striatum using [3H]-Spiperone as radioligandMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50017550(CHEMBL76399 | N*6*-Propyl-4,5,6,7-tetrahydro-benzo...)
Show SMILES CCCNC1CCc2nc(N)sc2C1
Show InChI InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
Affinity DataIC50: 280nMAssay Description:Inhibitory activity against dopamine receptor D2 in rat corpus striatum using [3H]-Apomorphine as radioligandMore data for this Ligand-Target Pair