BDBM50017896 (E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid::3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid::CHEMBL11662::CHEMBL542549::Ozagrel::cid_5282440

SMILES OC(=O)\C=C\c1ccc(Cn2ccnc2)cc1

InChI Key InChIKey=SHZKQBHERIJWAO-AATRIKPKSA-N

Data  14 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50017896   

TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Southern Research Institute

Curated by PubChem BioAssay
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  3.43E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against human thromboxane synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of thromboxane A2 synthetase as reduced ADP-induced aggregation of human platelet rich plasma in the presence of pig aortal microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Chugai Pharmaceutical Company

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  200nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in rat whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  300nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in human plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  900nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro thromboxane-A2 receptor binding affinity to displace by 50% [3H]-SQ 29548 binding from washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Chugai Pharmaceutical Company

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  640nMAssay Description:In vitro inhibition of thromboxane-A2 synthase in rat whole blood during clotting at 37 degrees centigradeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  300nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in human plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Chugai Pharmaceutical Company

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  200nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in rat plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  24nMAssay Description:In vitro inhibition of thromboxane synthase (TXA2) in human platelet microsomes [reduced formation of TXB2 from prostaglandin H2(PGH2)]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  24nMAssay Description:In vitro inhibition of TXB2 production by incubating prostaglandin H2 with human platelet microsomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  24nMAssay Description:Thromboxane A2 synthase inhibitory activity was measured from inhibition of thromboxane B2 production in human platelet microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against Thromboxane A2 synthase in human platelet microsomeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Southern Research Institute

Curated by PubChem BioAssay
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataEC50: >5.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay