BDBM50020874 (3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine::CHEMBL332898

SMILES Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1

InChI Key InChIKey=CEHQLKSLMFIHBF-UHFFFAOYSA-N

Data  2 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50020874   

LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataKi:  9.50E+3nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity for low Km cAMP phosphodiesterase PDE III of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [Ca(2+)]-calmodulin-dependent cGMP-phosphodiesterase 1 from porcine coronary arteriesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Sus scrofa)
Eisai

Curated by ChEMBL
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of cGMP-inhibited phosphodiesterase from porcine coronary arteriesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human platelets PDE2 at 10 uM using cAMP as substrate incubated for 30 mins in presence of [3H]cAMP and cGMP by liquid scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of cGMP-stimulated phosphodiesterase 2 of porcine coronary arteriesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataIC50:  600nMAssay Description:Inhibition of PDE5 (unknown origin) using 0.4 uM cGMP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of bovine aortic smooth muscle PDE5 using cGMP as substrate incubated for 30 mins in presence of EGTA and [3H]cGMP by liquid scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataIC50:  500nMAssay Description:Inhibition of phosphodiesterase 5AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity against phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
Eisai

Curated by ChEMBL
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataIC50:  3.72E+4nMAssay Description:Inhibition of cAMP specific phosphodiesterase from porcine coronary arteriesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed