Compile Data Set for Download or QSAR
maximum 50k data
Found 436 Enz. Inhib. hit(s) with Target = 'Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C'
LigandPNGBDBM50225506(CHEMBL150093)
Affinity DataKi:  4.00E+3nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataKi:  9.50E+3nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225509(Oxagrelate | SC-32840)
Affinity DataKi:  1.00E+4nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50059033((11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of human phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225507(CHEMBL151056)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027177(Cilostamide)
Affinity DataKi:  2.20E+4nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225504(EHT-0202 | Etazolate | SQ-20009)
Affinity DataKi:  6.00E+4nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of sheep lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225505(CHEMBL358641 | ICI-58301)
Affinity DataKi:  7.17E+5nMAssay Description:Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of sheep lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169627(7-Cyclopentyl-2-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169633(7-Cyclopentyl-2-[2-ethoxy-5-(4-methyl-piperazine-1...)
Affinity DataIC50:  10nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50024352(CHEMBL183857)
Affinity DataIC50:  10nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169634(3-Cyclopentyl-5-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169641(2-{2-Ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-su...)
Affinity DataIC50:  20nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169648(3-Cyclopentyl-5-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Affinity DataIC50:  30nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169635(7-Cyclopentyl-2-(2-ethoxy-phenyl)-5-methyl-3H-imid...)
Affinity DataIC50:  30nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169643(8-Cyclopentyl-2-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Affinity DataIC50:  30nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169651(8-Cyclopentyl-2-(2-ethoxy-phenyl)-6-methyl-3H-imid...)
Affinity DataIC50:  40nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50170491(6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-pyrid...)
Affinity DataIC50:  43nMAssay Description:Inhibitory concentration against Phosphodiesterase type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169636(3-Cyclopentyl-6-(2-ethoxy-phenyl)-7H-[1,2,4]triazo...)
Affinity DataIC50:  50nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169632(3-Cyclopentyl-6-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Affinity DataIC50:  50nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50289368(Butane-1-sulfonic acid [3-(2,3-dibromo-5-oxo-5,6-d...)
Affinity DataIC50:  85nMAssay Description:In vitro inhibition of phosphodiesterase (PDE I).More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50170480(6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-pyrid...)
Affinity DataIC50:  87nMAssay Description:Inhibitory concentration against Phosphodiesterase type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169645(2-(2-Ethoxy-phenyl)-6-methyl-8-propyl-3H-imidazo[1...)
Affinity DataIC50:  200nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169631(3-Cyclopentyl-5-(2-ethoxy-phenyl)-6H-isoxazolo[4,5...)
Affinity DataIC50:  200nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50470992(CHEMBL6744)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against calmodulin-dependent Phosphodiesterase was reported.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50170492(6-Phenoxymethyl-pyridine-2-carboxylic acid [4-(1-h...)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration against Phosphodiesterase type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50470995(CHEMBL267600)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against calmodulin-dependent Phosphodiesterase was reported.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470999(CHEMBL6410)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against calmodulin-dependent Phosphodiesterase was reported.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  270nMAssay Description:Inhibitory activity against phosphodiesterase-1 (PDE1) isolated from canine lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50111902(2-(2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phen...)
Affinity DataIC50:  300nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50111897(2-(2-Ethoxy-phenyl)-3,5-dimethyl-7-propyl-3H-imida...)
Affinity DataIC50:  300nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50471000(CHEMBL6718)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against calmodulin-dependent Phosphodiesterase was reported.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50178874(7-(2-hydroxy-3-(naphthalen-2-yloxy)propyl)-8-merca...)
Affinity DataIC50:  300nMAssay Description:Inhibition of PDE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151635(8''-chloro-5''-(1H-1,2,3,4-tetraazol-5-ylmethoxy)s...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human PDE1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  350nMAssay Description:Inhibition of human phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50170554(1-Phenyl-1,4-dihydro-quinoline-4-carboxylic acid (...)
Affinity DataIC50:  380nMAssay Description:Inhibitory concentration against Phosphodiesterase type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50170501(6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-pyrid...)
Affinity DataIC50:  390nMAssay Description:Inhibitory concentration against Phosphodiesterase type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50470997(CHEMBL6617)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against calmodulin-dependent Phosphodiesterase was reported.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  400nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50075695(6,7-Dimethoxy-4-(3,4,5-trimethoxy-phenyl)-3H-napht...)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against phosphodiesterase 1 (PDE I), isolated from cardiac ventricleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50289353(2,3-Dibromo-8-(4-methoxy-phenyl)-6H-imidazo[1,2-d]...)
Affinity DataIC50:  450nMAssay Description:In vitro inhibition of phosphodiesterase (PDE I).More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50169628(9-Cyclopentyl-2-(2-ethoxy-phenyl)-1,9-dihydro-puri...)
Affinity DataIC50:  500nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50471001(CHEMBL269303)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against calmodulin-dependent Phosphodiesterase was reported.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50169637(2-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50:  500nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50470994(CHEMBL6327)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against calmodulin-dependent Phosphodiesterase was reported.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50151638(8''-chloro-5''-(5-hydroxy-1,2,4-oxadiazol-3-ylmeth...)
Affinity DataIC50:  610nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50170466(6-Phenoxymethyl-pyridine-2-carboxylic acid [4-(1-h...)
Affinity DataIC50:  630nMAssay Description:Inhibitory concentration against Phosphodiesterase type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50289357(1-Butyl-3-[3-(2,3-dibromo-5-oxo-5,6-dihydro-imidaz...)
Affinity DataIC50:  650nMAssay Description:In vitro inhibition of phosphodiesterase (PDE I).More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50151636(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  650nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50170479(6-Phenoxymethyl-pyridine-2-carboxylic acid [4-(1-h...)
Affinity DataIC50:  670nMAssay Description:Inhibitory concentration against Phosphodiesterase type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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