BDBM50022279 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)-benzyl]-1-heptyl-urea::CHEMBL277986::CL-277082

SMILES CCCCCCCN(Cc1ccc(CC(C)(C)C)cc1)C(=O)Nc1ccc(F)cc1F

InChI Key InChIKey=QKJLDOBXDUVGEE-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50022279   

TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibition of intestinal Acyl coenzyme A:cholesterol acyltransferase in cholesterol-fed rabbits.More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  33nMAssay Description:In vitro inhibitory activity towards ACAT by the displacement of [1-14C]-oleolyl-CoA from the small intestine of cholesterol-fed rabbitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  740nMAssay Description:Compound was evaluated for the effect on Cholesterol O-Acyltransferase (ACAT) in Liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  320nMAssay Description:In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in liver microsomes isolated from cholesterol-fed rabbitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  33nMAssay Description:In vitro inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rabbit intestinal microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  3.20E+3nMAssay Description:In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  140nMAssay Description:Inhibition of smooth muscle cell ACAT activity for cells stimulated by cationized LDL.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  180nMAssay Description:Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit intestine microsomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  900nMAssay Description:Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  180nMAssay Description:Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  1.09E+3nMAssay Description:Compound was evaluated for the effect on Cholesterol O-Acyltransferase (ACAT) in Aorta (homogenate Low-density lipoproteins (LDL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  6.06E+3nMAssay Description:Inhibition of smooth muscle cell ACAT activity for cells stimulated by native LDL.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  810nMAssay Description:Compound was evaluated for the effect on Cholesterol O-Acyltransferase (ACAT) in intestinal microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Affinity DataIC50:  900nMAssay Description:Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit aorta homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed