BDBM50028166 CHEMBL934::METYRAPONE::US9138393, Metyrapone::US9144538, Metyrapone::US9394290, MTP (metyrapone)
SMILES CC(C)(C(=O)c1cccnc1)c1cccnc1
InChI Key InChIKey=FJLBFSROUSIWMA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 50028166
Affinity DataKi: 580nMAssay Description:Inhibition of bovine adrenal gland 11beta-hydroxylase assessed as inhibition of [14C]-deoxycorticosterone hydroxylationMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZ cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPTLC analysisMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 3.00E+3nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMT: 2°CAssay Description:V79MZ cells expressing human CYP11B1 and human CYP11B2 genes, respectively, were grown on 24-well cell culture plates (8×10^5 cells per well) w...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Affinity DataIC50: 72nMT: 2°CAssay Description:V79MZ cells expressing human CYP11B1 and human CYP11B2 genes, respectively, were grown on 24-well cell culture plates (8×10^5 cells per well) w...More data for this Ligand-Target Pair
Affinity DataIC50: 7.83E+3nMAssay Description:Evaluated for inhibition of bovine adrenal cortical mitochondrial 11 beta-hydroxylaseMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Affinity DataIC50: 5nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh11B1 cells using [1,2-3H]-11-deoxycorticosterone substrate incubated for 25 mins by HPLC metho...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh11B2 cells using [1,2-3H]-11-deoxycorticosterone substrate incubated for 25 mins by HPLC metho...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human placental microsomal CYP19 using [1beta-3H]androstenedione substrate pre-incubated for 5 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of human CYP11B1 expressed in V79 MZ cells pretreated with compound for 1 hr followed by addition of 500 nM 11-deoxycorticosterone for 3 h...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Affinity DataIC50: 208nMAssay Description:Inhibition of human aldosterone synthase expressed in V79 MZ cells pretreated with compound for 1 hr followed by addition of 500 nM 11-deoxycorticost...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human CYP11B1 expressed in hamster fibroblast using 100 nM [3H]-11-deoxycorticosterone as substrate after 25 mins by HPLC analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP11B2 expressed in hamster fibroblast using 100 nM [3H]-11-deoxycorticosterone as substrate after 45 mins by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human CYP19 expressed in hamster fibroblast using 500 nM [1beta-3H] androstenedione as substrate by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.61E+3nMAssay Description:Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.93E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Saarland University
Curated by ChEMBL
Saarland University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 14.6nMAssay Description:Inhibition of human steroid-11beta-hydroxylase expressed in chinese hamster V79 cells using 11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Affinity DataIC50: 72nMAssay Description:Inhibition of human aldosterone synthase expressed in chinese hamster V79 cells using 11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrateMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZ cells using [3H] 11 deoxycorticosterone as substrate by HPLC radioflow detectorMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZ cells using [3H] 11 deoxycorticosterone as substrate by HPLC radioflow detectorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.29E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of rat CYP11B1 expressed in hamster V79MZ cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPLC analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZ cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZ cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP11B1 in Sprague-Dawley rat adrenal tissue using 11-deoxycorticosterone as substrate after 4 hrs by SPAMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Universitaet Des Saarlandes Campus Saarbruecken
US Patent
Affinity DataIC50: 42nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair