BDBM50035179 Agomelatine::CHEMBL10878::N-[2-(7-Methoxy-naphthalen-1-yl)-ethyl]-acetamide::N-[2-(7-Methoxy-naphthalen-1-yl)-ethyl]-acetamide(Agomelatine)::S 20098::US10781182, Compound IA2-76::US11091445, Compound code IA2-76
SMILES COc1ccc2cccc(CCNC(C)=O)c2c1
InChI Key InChIKey=YJYPHIXNFHFHND-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 70 hits for monomerid = 50035179
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.0420nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.0600nMAssay Description:Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]-iodomelatonin as ra...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.0600nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
TargetMelatonin receptor type 1A(GUINEA PIG)
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.100nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.100nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Dissociation constant of the compound (KI) for the Pancreatic cholesterol esterase-catalyzed hydrolysis of 4-nitrophenyl butyrateMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.100nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.100nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(GUINEA PIG)
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.120nMAssay Description:Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.120nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.180nMAssay Description:Binding affinity for human melatonin receptor type 1A, expressed in HEK-293 cells (2-[125I]-Iodomelatonin is used as radioligand)More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.200nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.200nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.200nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.200nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.210nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.210nMAssay Description:Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.270nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.270nMAssay Description:Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]-iodomelatonin as ra...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.450nMAssay Description:Binding affinity for melatonin receptor type 1B, expressed in HEK-293 cells (2-[125I]-Iodomelatonin is used as radioligand)More data for this Ligand-Target Pair
Affinity DataKi: 0.537nMAssay Description:Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.540nMAssay Description:Competitive binding by the displacement of 2-[125I]- Iodomelatonin binding from melatonin receptors in chicken brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.540nMAssay Description:Inhibition of 2-[125I]- iodomelatonin from chicken brain melatonin receptorsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Institut De Recherches Servier
Curated by PDSP Ki Database
Institut De Recherches Servier
Curated by PDSP Ki Database
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Institut De Recherches Servier
Curated by PDSP Ki Database
Institut De Recherches Servier
Curated by PDSP Ki Database
Target5-hydroxytryptamine receptor 2C(PORCINE)
Institut De Recherches Servier
Curated by PDSP Ki Database
Institut De Recherches Servier
Curated by PDSP Ki Database
Target5-hydroxytryptamine receptor 2C(PORCINE)
Institut De Recherches Servier
Curated by PDSP Ki Database
Institut De Recherches Servier
Curated by PDSP Ki Database
Affinity DataKi: 630nMAssay Description:Binding affinity to 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 708nMAssay Description:Displacement of [3H]mesulergine from human 5HT2C receptor expressed in CHO cells after 60 minsMore data for this Ligand-Target Pair
Affinity DataKi: 708nMAssay Description:Displacement of [3H]-mesulergine from human 5-HT2C receptor expressed in CHO cell membranes after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Institut De Recherches Servier
Curated by PDSP Ki Database
Institut De Recherches Servier
Curated by PDSP Ki Database
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Institut De Recherches Servier
Curated by PDSP Ki Database
Institut De Recherches Servier
Curated by PDSP Ki Database
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Institut De Recherches Servier
Curated by PDSP Ki Database
Institut De Recherches Servier
Curated by PDSP Ki Database
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.40nMAssay Description:Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataEC50: 0.180nMAssay Description:Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataEC50: 0.100nMAssay Description:Agonist activity at human human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataEC50: 1.60nMAssay Description:Agonist activity at human human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair